Category: 636-73-7

Liu, Shuang published the artcileA Novel Ternary Ligand System for ^99mTc-Labeling of Hydrazino Nicotinamide-Modified Biologically Active Molecules Using Imine-N-Containing Heterocycles as Coligands, Application of Pyridine-3-sulfonic acid, the publication is Bioconjugate Chemistry (1998), 9(5), 583-595, database is CAplus and MEDLINE.

A hydrazinonicotinamide-functionalized cyclic platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonist [HYNICtide, cyclo(D-Val-NMeArg-Gly-Asp-Mamb(5-(6-(6-hydrazinonicotinamido)hexanamide)))] was labeled with ^99mTc using tricine and a series of imine-N-containing heterocycles as coligands. The imine-N-containing heterocycles include N-ω-Acetylhistamine (HIS-AC), N-(2-hydroxyethyl)isonicotinamide (ISONIC-HE), isonicotinic acid (ISONIC), isonicotinoyl-L-aspartic acid di-Me ester (ISONIC-L-Asp-OMe₂), 4-methyl-5-thiazoleethanol (MTE), nicotinic acid (NIC), 3-nitro-1,2,4-triazole (NTZ), 4-pyridylacetic acid (PA), 4-pyridineethanesulfonic acid (PES), and 3-pyridinesulfonic acid (PSA). The synthesis of these new ternary ligand [^99mTc]HYNICtide complexes can be performed in one or two steps in high yield and high specific activity (≥10 000 Ci/mmol HYNICtide). For example, the reaction of HYNICtide, [^99mTc]pertechnetate, nicotinic acid, stannous chloride, and tricine at pH ∼5 and 100° for 20 min results in the complex [^99mTc(HYNICtide)(tricine)(NIC)] in ≥90% yield as determined by radio-HPLC. It was found that ternary ligand technetium complexes, [^99mTc(HYNICtide)(tricine)(L)] (L = ISONIC, ISONIC-L-Asp-OMe₂, ISONIC-HE, MTE, PA, PES, and PSA) are formed as equal mixtures of two isomeric forms. Complex [^99mTc(HYNICtide)(tricine)(L)] (L = HIS-AC and NTZ) showed more than two well-resolved radiometric peaks at the retention times of interest, suggesting that they may have more than two forms in solution due to different bonding modalities of HIS-AC and NTZ. By a chirality experiment, it was found that the presence of two radiometric peaks is a result of the resolution of the two diastereomers which are formed by the combination of the chiral HYNICtide and the chiral technetium chelate. The formation of two diastereomers was also observed when a chiral imine-N-containing coligand was used for the radiolabeling of HYNIC-BA. The new ternary ligand [^99mTc]HYNICtide complexes were found to be stable for up to 6 h in the reaction mixture The high solution stability is attributed to their kinetic inertness. The composition of these complexes was determined to be 1:1:1:1 for Tc:HYNICtidepl:tricine (L = imine-N-containing heterocycles) through a series of mixed ligand experiments on the tracer (^99mTc) level. The lipophilicity of the ternary ligand [^99mTc]HYNICtide complexes can be systematically varied by the choice of polyaminocarboxylate and imine-N-containing coligands. Using the combination of tricine and an imine-N-containing coligand, HYNIC-derivatized peptides or other small mols. can be labeled with ^99mTc in high specific activity and high stability for potential use as radiopharmaceuticals.

Bioconjugate Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cotton, F. Albert published the artcileSynthesis and x-ray structure of two relatively air-stable chromium(II) 3-pyridinesulfonate compounds, Safety of Pyridine-3-sulfonic acid, the publication is Polyhedron (1992), 11(19), 2475-81, database is CAplus.

[Cr(pySO₃)₂(H₂O)₂]_n (I; pySO₃H = 3-pyridinesulfonic acid) and Cr(pySO₃)₂(py)₄ (II) were prepared and crystal structures determined I crystallizes as monoclinic, space group P2₁/c in an extended structure, a 7.723(1), b 12.995(4), c 7.276(3) Å, β 100.24(2)°, Z = 2, R = 0.032, R_w = 0.046. II possesses a mol. structure and crystallizes as monoclinic, space group C2/c, a 17.084(4), b 11.031(3), c 17.828(7) Å, β 112.02(2)°, Z = 4, R = 0.031, R_w = 0.043. The coordination about the Cr atoms is, in both cases, highly distorted. Both compounds are relatively stable towards O in the solid state, especially I.

Polyhedron published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Safety of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lee, Norizan A. published the artcileA natural isolate of Pseudomonas maltophila which degrades aromatic sulfonic acids, Recommanded Product: Pyridine-3-sulfonic acid, the publication is FEMS Microbiology Letters (1993), 107(2-3), 151-5, database is CAplus and MEDLINE.

A natural isolate, designated BSA56, which was originally selected for growth with benzenesulfonic acid as sole carbon and energy source, was identified as a strain of P. maltophila. Strain BSA56 grew on a wide range of aromatic sulfonic acids and was shown to release sulfite from benzenesulfonic acid and 2-naphthalenesulfonic acid. Although it also grew on toluenesulfonic acid and pyridinesulfonic acid, no significant sulfite release was observed with these substrates. Release of sulfite from benzenesulfonic acid was greatly promoted by the presence of glycerol. The ability to release sulfite was induced by growth in the presence of benzenesulfonic acid and was repressed almost entirely by substrates allowing rapid growth such as acetate. Strain BSA56 grew better at 30° than 37° on most aromatic substrates, but the reverse was true for most aromatic sulfonates. Several mutants of BSA56 were isolated with defects in benzoate, salicylate, or gentisate metabolism However, all these mutants retained the ability to degrade the aromatic sulfonates.

FEMS Microbiology Letters published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Egbertson, Melissa S. published the artcileNon-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Journal of Medicinal Chemistry (1999), 42(13), 2409-2421, database is CAplus and MEDLINE.

The synthesis and pharmacol. of a potent thienothiophene non-peptide fibrinogen receptor antagonist (I) are reported. Compound I inhibited the aggregation of human gel-filtered platelets with an IC₅₀ of 8 nM and demonstrated an 8-fold improvement in affinity for isolated GPIIb/IIIa receptors over analogs possessing an isoindolinone backbone. Flow cytometry studies revealed that the binding of I to resting platelets is a diffusion-controlled process (k_on = 3.3 × 10⁶ M^-1 s^-1) and that I binds to dog and human platelets with comparable affinity (K_d = 0.04 and 0.07 nM, resp.). Ex vivo platelet aggregation in dogs was completely inhibited by an i.v. dose of 5 mg/kg, and an oral dose of 50-90 mg/kg followed by low daily doses of 10 mg/kg was sufficient to maintain ∼80% inhibition of ex vivo platelet aggregation over several days. Inhibition of ADP-induced platelet aggregation in anesthetized dogs at 77 ± 7% resulted in a moderate 2.5-fold increase in bleeding time, while complete inhibition (100%) resulted in an approx. 10-min bleeding time. Addnl. doses were required to increase the bleeding time to the maximum time allowed in the protocol (15 min), thus indicating a potentially useful and safe separation of efficacy and bleeding time.

Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Egbertson, Melissa S. published the artcileNon-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation. [Erratum to document cited in CA131:179285], Synthetic Route of 636-73-7, the publication is Journal of Medicinal Chemistry (1999), 42(19), 4014, database is CAplus.

On page 2409, in the Abstract, line 8, mg/kg should be μg/kg. On page 2412, in Table 3, the correct values are flow cytometry K_D = 2.2 nM and fold difference K_D/ED₅₀ = 5.7. On page 2413, under Single-Dose I.v. and Oral Administration of 4 to Conscious Dogs, lines 11, 16, 18, and 22, mg/kg should be μg/kg. On page 2414, in line 1 and under Once-Daily Oral Administration of 4 for 6 days to Conscious Dogs by Gastric Lavage, line 13, mg/kg should be μg/kg. On page 2419, under Single-Dose I.v. and Oral Administration of 4 to Conscious Dogs, line 12, μ/kg should be μg/kg. On page 2421, in reference 16, last line, 1,000,000 should be 100,000: “20,000 to 100,000 receptors/platelet”.

Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Synthetic Route of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gezerman, A. O. published the artcileIron(II) acetylacetonate containing brightener and sulphur containing carrier in nickel plating, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Surface Engineering (2013), 29(7), 516-521, database is CAplus.

The effects of an Fe(II) acetylacetonate containing brightening agent and a carrier on color and mech. properties of Ni plating were studied to determine optimal electroplating process parameters. The brightening agent contained metasulfobenzaldehyde, pyridine-3-sulfonic acid, p-vinylbenzenesulfonic acid, o-benzoylsulfonamide, Na saccharine and Fe(II) acetylacetonate. The carrier comprised Na saccharine and Na allyl sulfonate in H₂O. Plating color was analyzed by visible region spectrophotometry at 350 nm under 6500 K illumination (CIE Standard Illuminant D65). Electron microscopy confirmed that carrier facilitated Ni deposition onto the surface and increased cohesion, thus allowing complete coverage. Also, brightening agent increased the bath pH, while carrier did not. In bending experiments on a coated plate, brightening agent increased H embrittlement, although desired decorative appearance was obtained. Finally, the optimum concentrations of carrier and brightening agent are 12 and 0·4 g L-1, resp.

Surface Engineering published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gezerman, Ahmet Ozan published the artcileAnalysis of the characteristics of nickel-plating baths, Category: pyridine-derivatives, the publication is International Journal of Chemistry (Toronto, ON, Canada) (2010), 2(2), 124-137, database is CAplus.

Ni plating processes, popularly used in Europe since 1950s, were increasingly employed in Turkey in recent years. As a result, industrial usage has developed rapidly. Ni plating is the preferred process for this study because of the uniformity of the plating thickness on the plated surface and the ease with which complex components can be plated. It is also resistant to corrosion and has good levels of hardness. In this experiment, the following parameters were studied: the effect of varying the amount of Ni, the thickness of the plating, and sheen (whether shiny or dull). Brightening and carrying agents were used to determine the best operational parameters for the Kale Kilit Factory. The compositions of the brightening and carrying agents used in the experiment are included in this text. Addnl., studies were conducted on how the plating color changed when compared to the original bath as a result of using Fe²⁺ complex concentration in Ni plating baths, as a brightening agent and for analyzing the color of the plated sample, under a visible region spectrophotometer at 350 nm and 6500 K light power and D65 (Average North Sky Daylight) light. In the authors’ research, the most important feature of anal. is that the desired color effect was obtained by using brightening agents containing Fe²⁺ complex concentration without any interference from any colorant after Ni plating by electrolysis. In this study where Ni plating bath characteristics are researched, phys. tests such as brittle test are applied to the plated materials, which provide the authors important ideas about the accuracy of the choices made according to standards

International Journal of Chemistry (Toronto, ON, Canada) published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kobayashi, Yuka published the artcileTailored cell sheet engineering using microstereolithography and electrochemical cell transfer, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Scientific Reports (2019), 9(1), 1-8, database is CAplus and MEDLINE.

Postoperative adhesion and occlusion remain a serious issue associated with various surgeries, including endoscopic surgery, in which proliferated fibrous tissues stick to adjacent tissues and often cause severe complications. Cell sheet engineering has emerged as an effective approach not only for cell transplantation but also for the treatment of postoperative adhesion and occlusion. However, as the tissues in the body, such as middle ear and small intestine, and typical operative sites are non-flat and spatially complicated, tailored cell sheets with three-dimensional (3D) configurations may lead to widespread use of this approach. In the present study, we used microstereolithog., biocompatible gold plating, and electrochem. cell detachment to achieve this purpose. Various objects with dimensions ranging from millimeter- to micrometer-scale were fabricated with photocurable resin using lab-made equipment for microstereolithog. To coat the fabricated objects with a thin gold layer, conventional cyanide-based gold plating was unusable because it severely damaged almost all cells. Electroless non-cyanide gold plating we prepared was cytocompatible and suitable for electrochem. cell detachment. Cell sheets on the gold-plated substrate could be directly transplanted into a mouse i.p. using electrochem. cell detachment. We further demonstrated that cell sheets grown on gold-coated 3D objects were rapidly detached along with the desorption of electroactive-oligopeptide monolayer and transferred to a surrounding hydrogel. This approach may provide a promising strategy to prepare and directly transplant tailor-made cell sheets with suitable configurations.

Scientific Reports published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Park, Hojoon published the artcileLigand-Enabled, Palladium-Catalyzed β-C(sp³)-H Arylation of Weinreb Amides, Category: pyridine-derivatives, the publication is ACS Catalysis (2018), 8(10), 9292-9297, database is CAplus and MEDLINE.

Authors report the development of Pd(II)-catalyzed C(sp³)-H arylation of Weinreb amides. Both the inductive effect and the potential bidentate coordination mode of the Weinreb amides pose a unique challenge for this reaction development. A pyridinesulfonic acid ligand is designed to accommodate the weak, neutral-coordinating property of Weinreb amides by preserving the cationic character of Pd center through zwitterionic assembly of Pd/ligand complexes. D. functional theory (DFT) studies of the C-H cleavage step indicate that the superior reactivity of 3-pyridinesulfonic acid ligand, compared to Ac-Gly-OH and ligandless conditions, originates from the stabilization of overall substrate-bound Pd species.

ACS Catalysis published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Winther-Jensen, Bjorn published the artcileVapor Phase Polymerization of Pyrrole and Thiophene Using Iron(III) Sulfonates as Oxidizing Agents, Application of Pyridine-3-sulfonic acid, the publication is Macromolecules (2004), 37(16), 5930-5935, database is CAplus.

Vapor phase polymerization is a versatile technique that can be used to obtain highly conducting coatings of conjugated polymer on both conducting and nonconducting substrates. This is demonstrated here by preparation of polypyrrole, polybithiophene, and polyterthiophene, coatings that otherwise must be prepared electrochem. in order to achieve the desired high conjugation. The method is based on the use of organic ferric sulfonates as oxidant as these salts easily form smooth, noncrystalline films. By proper choice of the sulfonate anion, the oxidizing power of the ferric salt can be varied over a wide range. The described technique can easily be adapted to different patterning techniques.

Macromolecules published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C14H20BClO2, Application of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem