Category: 636-73-7

Sicho, Vladislav; Kralova, Blanka published an article in 1966, the title of the article was Influence of antivitamins on the microbiological biosynthesis of vitamins. II. Stimulation of nicotinic acid biosynthesis in the microorganism Saccharomyces cerevisiae by pyridine-3-sulfonic acid.Formula: C5H5NO3S And the article contains the following content:

The influence of the antivitamin of nicotinic acid (I), pyridine-3-sulfonic acid (II) on I biosynthesis in S. cerevisiae was investigated. II stimulated I synthesis 3-fold when added at 25 μg./100 g. nutrient media. The increased production of I probably results from the compensating response of the respective controlling systems to the competitive inhibition of the antivitamin. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Formula: C5H5NO3S

The Article related to saccharomyces nicotinic acid, nicotinic acid saccharomyces, pyridinesulfonate nicotinate yeast, yeast pyridinesulfonate nicotinate, antivitamin yeast nicotinate, saccharomyces and other aspects.Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 31, 1979, Nicholson, S. H.; Suckling, C. J.; Iversen, L. L. published an article.HPLC of Formula: 636-73-7 The title of the article was GABA analogs: conformational analysis of effects on [3H]GABA binding to postsynaptic receptors in human cerebellum. And the article contained the following:

A study of the inhibition of Na-independent 3H-labeled GABA [56-12-2] binding to synaptic membranes of human brain cortex by synthesized simple substituted GABA mols. and some related aromatic and heterocyclic amino acids showed that C-alkyl or -aryl substitution of the GABA mol. markedly reduced its ability to bind to the receptor. Rigid mols. were also unable to interact strongly with the receptor. The larger and more numerous the substituents, the weaker was the receptor binding of the GABA analog. For binding to the GABA receptor, the substituent blocked the approach of the charged atom of the ligand to its complementary site on the receptor, and also raised the energy of that conformation required for binding to the receptor. A planar, eclipsed, partially folded conformation must be adopted by GABA when it binds to its receptor. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).HPLC of Formula: 636-73-7

The Article related to gaba receptor structure activity, Pharmacodynamics: Structure-Activity and other aspects.HPLC of Formula: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Madura, J. D.; Lombardini, J. B.; Briggs, J. M.; Minor, D. L.; Wierzbicki, A. published an article in 1997, the title of the article was Physical and structural properties of taurine and taurine analogs.Formula: C5H5NO3S And the article contains the following content:

The inhibition of the phosphorylation of an ∼20kDa protein present in the mitochondrial fraction of the rat retina by taurine and taurine analogs was investigated using computational methods. Correlations between mol. weight, mol. volume, and calculated pKa values vs. IC50 values are reported. These data appear to support the hypotheses according to Lombardini and Props that the inhibition of the phosphorylation of an ∼20 kDa protein by taurine and taurine analogs dependent on (i) the critical distance between the N and S atoms in the taurine moiety (S-C-C-N) of the analog, (ii) the environment of the N atom in the taurine analog (saturated ring vs. unsaturated ring), and (iii) the placement of both the S and N atoms not being present simultaneously in the ring structure. Using computational methods results supporting hypotheses (i) and (ii) are presented. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Formula: C5H5NO3S

The Article related to taurine qsar protein phosphorylation inhibition retina, Mammalian Biochemistry: Metabolism and other aspects.Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 11, 2017, Gunaga, Prashantha; Lloyd, John; Mummadi, Somanadham; Banerjee, Abhisek; Dhondi, Naveen Kumar; Hennan, James; Subray, Veena; Jayaram, Ramya; Rajugowda, Nagendra; Umamaheshwar Reddy, Kommuri; Kumaraguru, Duraimurugan; Mandal, Umasankar; Beldona, Dasthagiri; Adisechen, Ashok Kumar; Yadav, Navnath; Warrier, Jayakumar; Johnson, James A.; Sale, Harinath; Putlur, Siva Prasad; Saxena, Ajay; Chimalakonda, Anjaneya; Mandlekar, Sandhya; Conder, MaryLee; Xing, Dezhi; Gupta, Arun Kumar; Gupta, Anuradha; Rampulla, Richard; Mathur, Arvind; Levesque, Paul; Wexler, Ruth R.; Finlay, Heather J. published an article.Name: Pyridine-3-sulfonic acid The title of the article was Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide. And the article contained the following:

We have recently disclosed 5-phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine (I) as a potent IKur current blocker with selectivity vs. hERG, Na and Ca channels and an acceptable preclin. PK profile. On further characterization in vivo, Compound I demonstrated an unacceptable level of brain penetration. In an effort to reduce the level of brain penetration while maintaining the overall profile, SAR was developed at the C2′ position for a series of close analogs by employing hydrogen bond donors. As a result, 5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamide (II) was identified as the lead compound in this series. Compound II showed robust effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile and was advanced as the clin. candidate. Further optimization of II to mitigate pH dependent absorption resulted in identification of the corresponding phosphoramide prodrug (29) with an improved solubility and pharmacokinetic profile. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Name: Pyridine-3-sulfonic acid

The Article related to ph quinazoline sulfonamide synthesis pharmacokinetics brain potassium channel herg, pyridine sulfonamide antiarrhythmic atrial fibrillation, Pharmacology: Structure-Activity and other aspects.Name: Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Frosini, Maria; Sesti, Casilde; Saponara, Simona; Donati, Alessandro; Palmi, Mitri; Valoti, Massimo; Machetti, Fabrizio; Sgaragli, Gimpietro published an article in 2000, the title of the article was Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: A structure-activity relationship study.Category: pyridine-derivatives And the article contains the following content:

There is large body of evidences on the role of taurine in the central mechanisms of thermoregulation in mammals, but it is not clear, whether the hypothermic effect of taurine depends on its interaction with GABA receptors or with a specific receptor. In order to answer this question, the authors have performed a structure-activity relationship study by using both in vitro and in vivo preparations μM amounts of taurine or each of 20 analogs were injected intracerebroventricularly in conscious, restrained rabbits while rectal temperature was recorded. Receptor-binding studies, with synaptic membrane preparations from rabbit brain were used to determine the affinities of these compounds for GABAA and GABAB receptors. Furthermore, the interaction with presynaptic GABA and taurine uptake systems was studied using crude synaptosomal preparations from rabbit brain. Among the compounds tested, (±)-cis-2-aminocyclohexane sulfonic acid, induced hypothermia, but did not interact with GABAA and GABAB receptors neither did it affect GABA and taurine uptake, thus suggesting that its effect on body temperature is not mediated by the central GABA-ergic system. Interestingly, the trans-isomer was devoid of effects either in vivo or in vitro. In order to explain (±)-cis-2-aminocyclohexane sulfonic acid-induced hypothermia, a stereoscopic model was produced showing its possible interactions with a putative taurine brain receptor. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Category: pyridine-derivatives

The Article related to taurine structure activity thermoregulation brain, gaba taurine receptor thermoregulation brain, Pharmacology: Structure-Activity and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 31, 1996, Lombardini, John B. published an article.Safety of Pyridine-3-sulfonic acid The title of the article was Quantitative analysis of the combination dose-effects of taurine and taurine analogs on the phosphorylation of an ∼44-Kd protein present in a mitochondrial subfraction of rat heart. And the article contained the following:

Combinations of taurine and analogs of taurine that partially contain the N-C-C-S moiety within a semirigid saturated ring structure were tested for their effects on the phosphorylation of an ∼44-Kd protein present in the mitochondrial fraction of rat heart. (±)-Piperidine-3-sulfonic acid (PiP), an inhibitor of the phosphorylation of the ∼44-Kd protein with activity approx. similar to that of taurine, was observed to be mutually exclusive with taurine, i.e., to have a similar mode of action. The combination of taurine plus PiP in a fixed ratio mixture of 1:1 was slightly antagonistic at all concentrations (±)-Aminotetrahydrothiopyran-1,1-dioxide (APS), a sulfone derivative of taurine with a net pos. charge, also has approx. the same inhibitory activity as taurine. However, APS was mutually nonexclusive with taurine when tested in combination and thus appears to act independently of taurine. Taurine plus APS in a fixed ratio mixture of 3:1 was highly antagonistic at low concentrations of the mixture, approached an additive relation at 50% saturation, and became synergistic at high concentrations of the mixture Three analogs of taurine, pyridine-3-sulfonic acid (PyS), quinoline-8-sulfonic acid (QS), and 2-aminobenzenesulfonic acid (ABS), that have the basic taurine structure (N-C-C-S) partially in a semirigid unsaturated ring structure stimulate the phosphorylation of the ∼44-Kd protein. Due to the unsaturated ring structure, these analogs of taurine have a net neg. charge at physiol. pH and are not zwitterions. When PyS, QS, or ABS was titrated in the presence of a fixed concentration of taurine (10 mM), there was a competitive relation even through their electronic nature is quite different than that of taurine. The combination of QS plus PyS (1:5) appears to progress through a transition from being synergistic at low concentrations of the fixed ratio mixture, additive at 50% saturation, and finally antagonistic at high concentration of the fixed ratio mixture The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Safety of Pyridine-3-sulfonic acid

The Article related to taurine analog heart protein structure activity, Pharmacology: Structure-Activity and other aspects.Safety of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 1, 1995, Tanaka, Shunitz; Kodama, Kokoro; Kaneta, Takashi; Nakamura, Hiroshi published an article.Application In Synthesis of Pyridine-3-sulfonic acid The title of the article was Migration behavior of niacin derivatives in capillary electrophoresis. And the article contained the following:

The migration behavior of niacin derivatives was investigated by capillary zone electrophoresis (CZE) and micellar electrokinetic chromatog. (MEKC). When the pH of the buffer solution is lower than the pKa of the pyridine ring in the niacin derivatives, they are pos. charged by protonation on the pyridine ring and migrate electrophoretically. The mobilities of niacin derivatives in CZE were controlled by the pH of the migrating buffer. Good separation of 13 niacin derivatives was achieved at pH 2.8. Further, to shorten the anal. time and to achieve a more complete separation, an investigation by MEKC using SDS micelles was performed. All 13 niacin derivatives were eluted within 30 min and a satisfactory separation was achieved. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application In Synthesis of Pyridine-3-sulfonic acid

The Article related to niacin derivative migration capillary zone electrophoresis, micellar electrokinetic chromatog niacin derivative, Biochemical Methods: Electrical and other aspects.Application In Synthesis of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xing, Kai; Fan, Rui-Qing; Liu, Xiao-Yuan; Gai, Shuang; Chen, Wei; Yang, Yu-Lin; Li, Jing published an article in 2020, the title of the article was A self-calibrating dual responsive platform for the sensitive detection of sulfite and sulfonic derivatives based on a robust Hf(IV) metal-organic framework.Name: Pyridine-3-sulfonic acid And the article contains the following content:

A robust hafnium-based metal organic framework, Hf-PBTA, with sensitive and self-calibrating dual-emissive fluorescence response towards sulfite and sulfonic derivatives, including antibiotic sulfamethazine, has been developed, which shows fast detection of sulfite ions at a concentration as low as 76 ppb. The opposite response tendency from two radiative pathways towards aromatic sulfonic mols. and sulfite anions stems from the synergistic effect of the pyridine protonation effect, π-π stacking interaction and intramol. twist motion. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Name: Pyridine-3-sulfonic acid

The Article related to fluorescent sensor sulfite sulfonic derivative metal organic framework, Organic Analytical Chemistry: Determinations and other aspects.Name: Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 15, 2021, Wang, Qiang; Wang, Yujia; Chen, Lin; Sun, Xuzhuo; Li, Bo; He, Shuanglin; Li, Jun; Wang, Ning published an article.Formula: C5H5NO3S The title of the article was Introducing electrostatic interaction into Ru(bda) complexes for promoting water-oxidation catalysis. And the article contained the following:

Ru(bda) (H2bda = 2,2′-bipyridine-6,6′-dicarboxylic acid) complex is a kind of well-known water oxidation catalyst, which goes through the bimol. I2M mechanism with an inter-catalyst O-O coupling step. Recently, we developed two facile strategies to accelerate O-O coupling via introducing the electrostatic interaction into Ru(bda)-catalyzed systems. In this work, a series of Ru(bda) complexes with different charged groups on different positions were synthesized to demonstrate the general applicability of these design strategies. It found these catalytic systems with attractive electrostatic interaction display much better activity, and the position of the charged substituents also has a significant influence on the catalytic activity. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Formula: C5H5NO3S

The Article related to ruthenium bipyridine complex electrostatic interaction water oxidation, Placeholder for records without volume info and other aspects.Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 31, 2020, Jin, Lei; Yang, Jia-Qiang; Yang, Fang-Zu; Wu, De-Yin; Tian, Zhong-Qun published an article.Application In Synthesis of Pyridine-3-sulfonic acid The title of the article was Electrochemistry and coordination behaviors of hypoxanthine-Au (III) ion in the cyanide-free gold electrodeposition. And the article contained the following:

Alkaloid hypoxanthine is a novel complexant for green cyanide-free Au(III) electrodeposition. The electrochem. and coordination behaviors of hypoxanthine-Au(III) ion in the green cyanide-free bath were studied. The electrochem. behavior confirms that hypoxanthine-Au(III) ion is in the irreversible two-step electro-reductions with the 1st controlled by diffusion and the 2nd by diffusion and electrochem. The stability constant of hypoxanthine-Au(III) ion is 4.8 × 1030. DFT calculations further indicate that the optimal coordination structure is N3-Au-N7 with the N-Au average bond energy of 11.03 eV. The bath component of K citrate plays almost no influence, whereas the additive of sulfocompounds shows a significant effect on the electro-reduction of hypoxanthine-Au(III) ion. Based on the cyanide-free Au(III) electrodeposition bath, the obtained Au coating is fine and compact in grains without organic inclusion and in the resistivity of 2.84 × 10-8 Ω m. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application In Synthesis of Pyridine-3-sulfonic acid

The Article related to electrochem coordination hypoxanthine gold electrodeposition, Placeholder for records without volume info and other aspects.Application In Synthesis of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem