Category: 636-73-7

Yuasa, Makoto published the artcileSynergistic effect of organic additives and pulse-current plating in a gold electrodeposition acid bath and gold plating film corrosion resistance, Product Details of C5H5NO3S, the publication is Hyomen Gijutsu (1994), 45(8), 842-3, database is CAplus.

Effects of addition of pyridine derivatives such as aminopyridines and pyridinesulfonic acids into a citric acid-base Au electrodeposition solution were discussed. Using both pyridine additives and pulse current effectively lowered porosity and increased deposition efficiency compared to using only d.c. or pulse current and both d.c. and pyridine additives.

Hyomen Gijutsu published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C15H20N2O2, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Han, Fei published the artcileEffect of functional group position change of pyridinesulfonic acid as interface-modified layer on perovskite solar cell, Formula: C5H5NO3S, the publication is Applied Surface Science (2018), 517-525, database is CAplus.

There are fewer researches on the effect of functional group position change on device performance for highly efficient perovskite solar cell. In this work, we take pyridinesulfonic acid as an example, and study the effect of the isomeride: 2- and 3-pyridinesulfonic acid self-assembled monolayer on device performance for highly efficient perovskite solar cell. The efficiency of control device is 14.65% (Hysteresis Index = 0.31) under illumination of a simulated sunlight (AM 1.5G, 100 mW cm^-2). Through use of the 3-pyridinesulfonic acid self-assembled monolayer, the device exhibits striking improvements to reach the efficiency of 16.88% (Hysteresis Index = 0.02), which constitutes an enhancement compared to those of 2-pyridinesulfonic acid self-assembled monolayer modified device (16.54%, Hysteresis Index = 0.02). The enhanced photovoltaic performances can be attributed to the larger perovskite grain sizes, and easier passivation of electron transporting layer/perovskite interface, which promote the charge separation, transport and collection.

Applied Surface Science published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Funada, Atsushi published the artcileConformational Transformations of (C₁₂H₂₅NH₃⁺)(Pyridinesulfonate) in the Solid State, Related Products of pyridine-derivatives, the publication is Chemistry – An Asian Journal (2016), 11(6), 915-925, database is CAplus and MEDLINE.

The phase-transition behaviors, crystal structures, and dielec. properties of four kinds of simple 1:1 organic salts of (C₁₂H₂₅NH₃⁺)(benzenesulfonate) and (C₁₂H₂₅NH₃⁺)(pyridine sulfonates) were examined from the viewpoint of intermol. hydrogen-bonding interactions and dynamic conformational transformation in mol. assemblies. Crystals of (C₁₂H₂₅NH₃⁺)(benzenesulfonate) and (C₁₂H₂₅NH₃⁺)(3-pyridinesulfonate) were isostructural and solid-solid and solid-liquid-crystal smectic A (SmA) phase transitions were observed These two crystals formed rodlike cation-anion assemblies. However, the two salts, (C₁₂H₂₅NH₃⁺)(2-pyridinesulfonate) and (C₁₂H₂₅NH₃⁺)(4-pyridinesulfonate), formed largely bent L-shaped cation-anion conformations. Interesting conformational transformations from rodlike to L-shaped assemblies were observed in (C₁₂H₂₅NH₃⁺)(2-pyridinesulfonate) and (C₁₂H₂₅NH₃⁺)(3-pyridinesulfonate).

Chemistry – An Asian Journal published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Yongliang published the artcileN-alkylation of pyridylalanine and pyridinecarboxylic acids and their use in synthesis of GnRH antagonists, Synthetic Route of 636-73-7, the publication is Tetrahedron Letters (1993), 34(23), 3659-62, database is CAplus.

A mild N-alkylation method has been developed for the synthesis of N-alkylated pyridiniumcarboxylic acids using Ag₂O-H₂O catalysis to enhance the low reactivity of pyridinecarboxylic acids. Two approaches were undertaken for the synthesis of a series of GnRH antagonists containing pyridinium moieties at the side chain: (1) incorporation of alkylated D-pyridylalanine analogs I (Boc = Me₃CO₂C; R = Me, CH₂Ph, CHMe₂, Bu) during solid phase peptide chain assembly, and (2) coupling of the N-alkylated pyridiniumcarboxylic acid to a D-lysine ε-amino group on a solid support.

Tetrahedron Letters published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C18H35NO, Synthetic Route of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hurh, Byungserk published the artcilePurification and characterization of nicotinic acid dehydrogenase from Pseudomonas fluorescens TN5, Synthetic Route of 636-73-7, the publication is Journal of Fermentation and Bioengineering (1994), 78(1), 19-26, database is CAplus.

Membrane-bound nicotinic acid dehydrogenase, an enzyme that catalyzes the formation of 6-hydroxynicotinic acid from nicotinic acid, was solubilized with Triton X-100, and then purified 126-fold with an 11.1% overall recovery from nicotinic acid-induced cells of Pseudomonas fluorescens TN5. The purified enzyme appeared to be homogeneous from anal. by polyacrylamide gel electrophoresis. The enzyme had a mol. mass of approx. 80 kDa and consisted of one subunit. Some electron acceptors, such as phenazine methosulfate, K₃Fe(CN)₆ and nitro blue tetrazolium, acted as electron acceptors. The purified enzyme catalyzed the hydroxylation of nicotinic acid to 6-hydroxynicotinic acid at a rate of 672 μmol min^-1 mg^-1 of protein at 35°. It also catalyzed the hydroxylation of pyrazinecarboxylic acid, 3-pyridinesulfonic acid, and 3-cyanopyridine. The purified enzyme exhibited an optimum pH of 8.3, and was sensitive to thiol reagents such as HgCl₂ and p-chloromercuribenzoate. A reduction in the amount of the cytochrome c-like component in the respiratory particles was observed during the hydroxylation reaction of nicotinic acid. Thus, nicotinic acid dehydrogenase appeared to be linked to the cytochrome respiratory chain in the cells of P. fluorescens TN5.

Journal of Fermentation and Bioengineering published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Synthetic Route of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yu, Miao published the artcileA Practical and Robust Multistep Continuous Process for Manufacturing 5-Bromo-N-(tert-butyl)pyridine-3-sulfonamide, Product Details of C5H5NO3S, the publication is Organic Process Research & Development (2019), 23(9), 2088-2095, database is CAplus.

A multistep continuous flow process involving (1) magnesium-halogen exchange, (2) sulfonylation with sulfuryl chloride, and (3) reaction with tert-butylamine was developed for the synthesis of an arylsulfonamide pharmaceutical intermediate in the synthesis of BMS-919373. The process was successfully implemented, including a robust control strategy to manage the levels of several process impurities, to produce 76 kg of 5-bromo-N-(tert-butyl)pyridine-3-sulfonamide (I). As the instability of the reactive intermediates and existence of strong exotherms made a batch process unsuitable for production beyond a 1 kg scale, the alternative continuous process led to a practical and robust manufacturing route to the active pharmaceutical ingredient.

Organic Process Research & Development published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C23H20BN, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Frosini, Maria published the artcileInteractions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain, Quality Control of 636-73-7, the publication is British Journal of Pharmacology (2003), 138(6), 1163-1171, database is CAplus and MEDLINE.

The aim of this study was to find taurinergic compounds that do not interact with brain GABAergic systems. Washed synaptic membranes (SM) from whole rabbit brain were able to bind [³H]muscimol. Saturation experiments of the binding of [³H]GABA to GABA_B receptors showed that SM possess two binding components; twice Triton X-100-treated SM contained 0.048 mmol endogenous taurine/kg protein and bound [³H]taurine in a saturable manner (K_d = 249.0 nM and B_max = 3.4 pmol mg^-1 prot). Among the 19 structural analogs of taurine, 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (TAG), 2-aminoethylarsonic (AEA), 2-hydroxyethanesulfonic (ISE) and (±)cis-2-aminocyclohexane sulfonic acids (CAHS) displaced [³H]taurine binding (K_i = 0.13, 0.13, 13.5 and 4.0 μM, resp.). These analogs did not interact with GABA_A and GABA_B receptors and did not affect taurine- and GABA-uptake systems and GABA-transaminase activity. 3-Aminopropanesulfonic acid (OMO), β-alanine, pyridine-3-sulfonic acid, N,N,N-trimethyltaurine (TMT), 2-(guanidino)ethanesulfonic acid (GES), ethanolamine-O-sulfate, N,N-dimethyltaurine (DMT), taurine and (±)piperidine-3-sulfonic acid (PSA) inhibited [³H]muscimol binding to GABA_A receptors with different affinities (K_i = 0.013, 7.9, 24.6, 47.5, 52.0, 91.0, 47.5, 118.1 and 166.3 μM, resp.). Taurine, 2-aminoethylphosphonic acid, DMT, TMT and OMO inhibited the binding of [³H]GABA to GABA_B receptors with K_i‘s in the μM range (0.8, 3.5, 4.4, 11.3 and 5.0, resp.). GES inhibited taurine uptake (IC₅₀ = 3.72 μM) and PSA GABA transaminase activity (IC₅₀ = 103.0 μM). In conclusion, AEA, TAG, ISE and CAHS fulfill the criteria for taurinergic agents.

British Journal of Pharmacology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Frosini, Maria published the artcileEffects of taurine and some structurally related analogues on the central mechanism of thermoregulation: A structure-activity relationship study, Product Details of C5H5NO3S, the publication is Advances in Experimental Medicine and Biology (2000), 273-282, database is CAplus and MEDLINE.

There is large body of evidences on the role of taurine in the central mechanisms of thermoregulation in mammals, but it is not clear, whether the hypothermic effect of taurine depends on its interaction with GABA receptors or with a specific receptor. In order to answer this question, the authors have performed a structure-activity relationship study by using both in vitro and in vivo preparations μM amounts of taurine or each of 20 analogs were injected intracerebroventricularly in conscious, restrained rabbits while rectal temperature was recorded. Receptor-binding studies, with synaptic membrane preparations from rabbit brain were used to determine the affinities of these compounds for GABA_A and GABA_B receptors. Furthermore, the interaction with presynaptic GABA and taurine uptake systems was studied using crude synaptosomal preparations from rabbit brain. Among the compounds tested, (±)-cis-2-aminocyclohexane sulfonic acid, induced hypothermia, but did not interact with GABA_A and GABA_B receptors neither did it affect GABA and taurine uptake, thus suggesting that its effect on body temperature is not mediated by the central GABA-ergic system. Interestingly, the trans-isomer was devoid of effects either in vivo or in vitro. In order to explain (±)-cis-2-aminocyclohexane sulfonic acid-induced hypothermia, a stereoscopic model was produced showing its possible interactions with a putative taurine brain receptor.

Advances in Experimental Medicine and Biology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mueller, Sebastian L. published the artcileSystematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201, COA of Formula: C5H5NO3S, the publication is European Journal of Medicinal Chemistry (2017), 124-134, database is CAplus and MEDLINE.

GluN2A subunit containing N-methyl-D-aspartate receptors (NMDARs) are highly involved in various physiol. processes in the central nervous system, but also in some diseases, such as anxiety, depression and schizophrenia. However, the role of GluN2A subunit containing NMDARs in pathol. processes is not exactly elucidated. In order to obtain potent and selective inhibitors of GluN2A subunit containing NMDARs, the selective neg. allosteric modulator 2 was systematically modified at the benzenesulfonamide part. The activity of the test compounds was recorded in two electrode voltage clamp experiments using Xenopus laevis oocytes expressing exclusively NMDARs with GluN1a and GluN2A subunits. It was found that halogen atoms in 3-position of the benzenesulfonamide part result in high GluN2A antagonistic activity. With an IC₅₀ value of 204 nM the 3-bromo derivative 5i (N-{4-[(2-benzoylhydrazino)carbonyl]benzyl}-3-bromobenzenesulfonamide) has 2.5-fold higher antagonistic activity than the lead compound 2 and represents our new lead compound

European Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, COA of Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Schmuelling, M. published the artcileSteric and electronic tuning of the lability of square planar d⁸ metal complexes: platinum(II) â‰?palladium(II), Computed Properties of 636-73-7, the publication is Journal of the Chemical Society, Chemical Communications (1992), 1609-11, database is CAplus.

Electronic tuning of Pt^II complexes via cyclometalation, i.e. the introduction of a Pt-C bond trans to the leaving ligand, can increase their lability to that of related Pd^II complexes.

Journal of the Chemical Society, Chemical Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem