Category: 636-73-7

Makinen, Silja K. published the artcileHighly selective guest uptake in a silver sulfonate network imparted by a tetragonal to triclinic shift in the solid state, Formula: C5H5NO3S, the publication is Chemistry – A European Journal (2001), 7(23), 5176-5182, database is CAplus and MEDLINE.

The Ag sulfonate network presented herein, Ag 3-pyridinesulfonate, reversibly and selectively absorbs MeCN while undergoing a major structural rearrangement. The origin of this structural flexibility is a coupling of the weak coordinating ability of the SO₃ group with the geometrically pliant Ag(I) center. Single crystal and powder x-ray structures of both the desolvated and solvated forms are presented in addition to the mechanism of their reversible interconversion. A heterogeneous gas chromatog. study showing selective extraction of the MeCN is also presented. Extended solid frameworks which reorder to any extent are not common but the structure presented herein transforms from a tetragonal to a triclinic crystal system. The results indicate that cooperative interactions in systems based on supposedly weaker interactions can yield softer yet functional networks with behavior unlike that observed in more rigid inorganic frameworks.

Chemistry – A European Journal published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Galli, Ubaldina published the artcileIdentification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2, Application of Pyridine-3-sulfonic acid, the publication is European Journal of Medicinal Chemistry (2012), 58-66, database is CAplus and MEDLINE.

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogs of nicotinamide. Biol. data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.

European Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Neudeck, Sven published the artcileNew Powerful and Oxidatively Rugged Dinuclear Ru Water Oxidation Catalyst: Control of Mechanistic Pathways by Tailored Ligand Design, Name: Pyridine-3-sulfonic acid, the publication is Journal of the American Chemical Society (2014), 136(1), 24-27, database is CAplus and MEDLINE.

A new powerful and oxidatively rugged pyrazolate-based water oxidation catalyst of formula {[Ru^II(py-SO₃)₂(H₂O)]₂(μ-Mebbp)}^–, 1(H₂O)₂^–, has been prepared and thoroughly characterized spectroscopically and electrochem. This new catalyst has been conceived based on a specific ligand tailoring design, so that its performance has been systematically improved. It was also demonstrated how subtle ligand modifications cause a change in the O-O bond formation mechanism, thus revealing the close activation energy barriers associated with each pathway.

Journal of the American Chemical Society published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Decristoforo, Clemens published the artcile99M-technetium-labelled peptide-HYNIC conjugates: Effects of lipophilicity and stability on biodistribution, Computed Properties of 636-73-7, the publication is Nuclear Medicine and Biology (1999), 26(4), 389-396, database is CAplus and MEDLINE.

The aim of this study was to explore the effects of lipophilicity and stability on the biodistribution of ^99mTc labeled peptides through the use of different co-ligands. 6-Hydrazinopyridine-3-carboxylic acid (HYNIC) was coupled to the somatostatin analog RC160 and radiolabeled using a range of ethylenediaminediacetic acid (EDDA) and EDTA derivatives as well as tricine and pyridine/tricine as co-ligands. After labeling with technetium-99m, chromatog., stability, protein-binding, and rat biodistribution studies were performed. For most co-ligands, biodistribution correlated well with in vitro properties. Lipophilic substitution on EDDA resulted in higher protein binding, increased liver uptake, and intestinal excretion. Stabilization of tricine with pyridines reduced blood levels and lowered liver uptake. EDTA derivatives showed high instability in vitro and in vivo.

Nuclear Medicine and Biology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Hong-hong published the artcileSynthesis and catalytic esterification of a novel solid acid catalyst 3-pyridine sulfonic acid-phosphomolybdic acid, Category: pyridine-derivatives, the publication is Huaxue Shiji (2016), 38(6), 506-510, database is CAplus.

A novel solid acid was synthesized by the reaction of 12-molybdophosphoric acid (HPM) with 3-pyridine sulfonic acid (PSA) and confirmed by X-ray powder diffraction, FT-IR, TG and potentiometric titration Then the solid acid was employed for esterification to evaluate its acid-catalytic activity. Various reaction parameters, including methanol/oleic acid molar ratio, catalyst dosage, reaction temperature and time were systematically examined These results indicated that the prepared catalyst maintained the Keggin structure of the raw HPM, and exhibited good thermal stability and higher acidity. The catalyst exhibited excellent catalytic activity in esterification and good reusability. 96.5% Conversion of oleic acid was obtained under the following conditions: mole ratio of alc. to acid 7:1, the reaction temperature 80°C, catalyst amount 10 wt% of the weight of oleic acid and the reaction time 5 h. After the fourth recycling, there was no obvious change in phase and Keggin structure for the catalysts.

Huaxue Shiji published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C9H22OSi, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Feng published the artcileHydrogen bonding effects on topological structures of two supramolecular transition metal coordination complexes based on organosulphonate ligands, Formula: C5H5NO3S, the publication is Inorganic Chemistry Communications (2010), 13(5), 656-658, database is CAplus.

The syntheses, x-ray crystal structures and topol. analyses of two supramol. coordination complexes, [Co(H₂O)₄(ps)₂] 1 and [Cu(H₂O)₂(ps)₂] 2 (ps^– = pyridine-3-sulfonic anion), are reported. Although the basic coordination environments and patterns around the metal centers of 1 and 2 are similar, the overall topologies of the two complexes are very different due to the formation of distinct hydrogen bonding interactions resulting from organosulfonate ligands.

Inorganic Chemistry Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Madura, J. D. published the artcilePhysical and structural properties of taurine and taurine analogs, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Amino Acids (1997), 13(2), 131-139, database is CAplus.

The inhibition of the phosphorylation of an ∼20kDa protein present in the mitochondrial fraction of the rat retina by taurine and taurine analogs was investigated using computational methods. Correlations between mol. weight, mol. volume, and calculated pKa values vs. IC₅₀ values are reported. These data appear to support the hypotheses according to Lombardini and Props that the inhibition of the phosphorylation of an ∼20 kDa protein by taurine and taurine analogs dependent on (i) the critical distance between the N and S atoms in the taurine moiety (S-C-C-N) of the analog, (ii) the environment of the N atom in the taurine analog (saturated ring vs. unsaturated ring), and (iii) the placement of both the S and N atoms not being present simultaneously in the ring structure. Using computational methods results supporting hypotheses (i) and (ii) are presented.

Amino Acids published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gunaga, Prashantha published the artcileSelective I_Kur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide, HPLC of Formula: 636-73-7, the publication is Journal of Medicinal Chemistry (2017), 60(9), 3795-3803, database is CAplus and MEDLINE.

We have recently disclosed 5-phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine (I) as a potent I_Kur current blocker with selectivity vs. hERG, Na and Ca channels and an acceptable preclin. PK profile. On further characterization in vivo, Compound I demonstrated an unacceptable level of brain penetration. In an effort to reduce the level of brain penetration while maintaining the overall profile, SAR was developed at the C2′ position for a series of close analogs by employing hydrogen bond donors. As a result, 5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamide (II) was identified as the lead compound in this series. Compound II showed robust effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile and was advanced as the clin. candidate. Further optimization of II to mitigate pH dependent absorption resulted in identification of the corresponding phosphoramide prodrug (29) with an improved solubility and pharmacokinetic profile.

Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, HPLC of Formula: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Qiu, Zhi-Hui published the artcilecatena-Poly[[diaquamanganese(II)]-di-μ-pyridine-3-sulfonato-κ²N:O;κ²O:N], Quality Control of 636-73-7, the publication is Acta Crystallographica, Section E: Structure Reports Online (2008), 64(6), m765, m765/1-m765/7, database is CAplus and MEDLINE.

In the title polymeric complex, [Mn(C₅H₄NO₃S)₂(H₂O)₂]_n, the Mn atom is located on a center of inversion and is coordinated by two O atoms and two N atoms derived from four different pyridine-3-sulfonate (pySO₃) ligands, and two O atoms derived from two H₂O mols. in a distorted trans-N₂O₄ octahedral geometry. The metal atoms are bridged by the pySO₃ ligands to form a 1-dimensional chain. The chains are further connected into a three-dimensional architecture via H bonds. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ayesa, Susana published the artcileSolid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Bioorganic & Medicinal Chemistry (2009), 17(3), 1307-1324, database is CAplus and MEDLINE.

Highly potent and selective 4-amidofuran-3-one inhibitors of cathepsin S are described. The synthesis and structure-activity relation of a series of inhibitors with a sulfonamide moiety in the P3 position is presented. Several members of the series show sub-nanomolar inhibition of the target enzyme as well as an excellent selectivity profile and good cellular potency. Mol. modeling of the most interesting inhibitors describes interactions in the extended S3 pocket and explains the observed selectivity towards cathepsin K.

Bioorganic & Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem