Category: 637348-81-3

Reference of 637348-81-3, Adding some certain compound to certain chemical reactions, such as: 637348-81-3, name is 3-Bromo-5-iodopyridin-2-ol,molecular formula is C5H3BrINO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 637348-81-3.

Example 142b 3-Bromo-5-iodo-1-methylpyridin-2(1H)-one 142b A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with DMF (50 mL), 142a (6.0 g, 20.0 mmol), CH3I (4.26 g, 30.0 mmol), and K2CO3 (5.52 g, 40.0 mmol). The mixture was stirred at room temperature for 2 h and diluted with water (200 mL). The resulting white solid was collected by filtration to afford 142b (5.97 g, 95%) as a white solid. MS-ESI: [M+H]+ 314

According to the analysis of related databases, 637348-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Wei, BinQing; Young, Wendy B.; US2013/116246; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 637348-81-3, 3-Bromo-5-iodopyridin-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 637348-81-3, blongs to pyridine-derivatives compound. Product Details of 637348-81-3

Example 214b 3-Bromo-5-iodo-1-methylpyridin-2(1H)-one 214b A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with DMF (50 mL), 214a (6.0 g, 20.0 mmol), iodomethane (4.26 g, 30.0 mmol), and K2CO3 (5.52 g, 40.0 mmol). The mixture was stirred at room temperature for 2 h and diluted with water (200 mL). The resulting white solid was collected by filtration to afford 214b (5.97 g, 95%) as a white solid. MS-ESI: [M+H]+ 314

At the same time, in my other blogs, there are other synthetic methods of this type of compound,637348-81-3, 3-Bromo-5-iodopyridin-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; F.Hoffmann-La Roche AG; CRAWFORD, James John; ORTWINE, Daniel Fred; WEI, BinQing; YOUNG, Wendy B.; EP2773638; (2015); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 637348-81-3, name is 3-Bromo-5-iodopyridin-2-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C5H3BrINO

To a stirring suspension of 18 (see Example 4 above) (0.906 g, 3.0 mmol), 2-(tert-butyl-dimethyl-silanyloxy)ethanol (0.554 g, 3.15 mmol) and PPh3 (0.944 g, 3.6 mmol) in 20 mL of THF at -10 0C was added dropwise of diisopropylazodicarboxylate (DIAD) (0.728 g, 3.6 mmol) in 10 mL of THF. The ice-salt bath was removed and the reaction was kept at r.t. 2 h. The reaction solution was concentrated and purified by FC (EtOAc/Hexanes, 5/95) to afford 2-(tert-butyl-dimethyl-siianyloxy)ethoxy-3-bromo-5-iodorhoyridine, a colorless viscous liquid (0.995 g, 72%). 1H NMR £8.23 (d, IH, J= 2.0 Hz), 8.05 (d, IH, J= 2.0 Hz), 4.42 (t, 2H, J= 4.9 Hz), 3.98 (t, 2H, J= 4.9 Hz), 0.90 (s, 9H), 0.10 (s, 6H). HRMS calcd for C12H18BrINO2Si (M-CH3+), 441.9335; found, 441.9312.

The synthetic route of 637348-81-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; WO2007/126733; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem