Category: 64188-97-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64188-97-2, name is 3-Aminoisonicotinamide. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H7N3O

[00155j To a solution of 3-aminopyridine-4-carboxamide (5 g, 36.5 mmol) in THF (100 mL) was added triphosgene (11.9 g, 40.1 mmol) and TEA (7.4 g, 73 mmol). The reaction mixture was refluxed for 2h. The solution was concentrated in vacuo and the residue was triturated in water. The solid was filtered and washed with water and THF. The solid was dried to afford 4.lg (70%) of the title compound. ?H NMR (400 MHz, DMSO-d6): oe 11.62 (s, 1H), 11.58 (s, 1H), 8.66 (s, 1H), 8.40 (d, 1H,J= 5.2Hz), 7.80 (d, 1H,J 5.2 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 64188-97-2, 3-Aminoisonicotinamide.

Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; BOLOOR, Amogh; KANOUNI, Toufike; STAFFORD, Jeffrey Alan; VEAL, James Marvin; WALLACE, Michael Brennan; (173 pag.)WO2016/44429; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64188-97-2, name is 3-Aminoisonicotinamide. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H7N3O

[00155j To a solution of 3-aminopyridine-4-carboxamide (5 g, 36.5 mmol) in THF (100 mL) was added triphosgene (11.9 g, 40.1 mmol) and TEA (7.4 g, 73 mmol). The reaction mixture was refluxed for 2h. The solution was concentrated in vacuo and the residue was triturated in water. The solid was filtered and washed with water and THF. The solid was dried to afford 4.lg (70%) of the title compound. ?H NMR (400 MHz, DMSO-d6): oe 11.62 (s, 1H), 11.58 (s, 1H), 8.66 (s, 1H), 8.40 (d, 1H,J= 5.2Hz), 7.80 (d, 1H,J 5.2 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 64188-97-2, 3-Aminoisonicotinamide.

Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; BOLOOR, Amogh; KANOUNI, Toufike; STAFFORD, Jeffrey Alan; VEAL, James Marvin; WALLACE, Michael Brennan; (173 pag.)WO2016/44429; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 64188-97-2, 3-Aminoisonicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 64188-97-2, blongs to pyridine-derivatives compound. SDS of cas: 64188-97-2

To a suspension of 3-amino-2-carboxamide (1.0 eq) and methyl 2- (chlorocarbonyl)benzofuran-7-carboxylate (1.5 eq) in tetrahydrofuran was added N,N- diisopropylethylamine (3.0 eq) dropwise. The mixture was allowed to stir for 1 hour and concentrated in vacuo to afford methyl 2-((4-carbamoylpyridin-3- yl)carbamoyl)benzofuran-7-carboxylate as a crude product. The residue was used in the next step without further purification

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64188-97-2, 3-Aminoisonicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; DONG-A SOCIO HOLDINGS CO., LTD.; KIM, Myeong-seop; PARK, Taesun; YOON, Taeyoung; YANG, Seung Min; KIM, Hae-Sun; KIM, Jun Gyu; (285 pag.)WO2016/68580; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem