Category: 6419-36-9

Related Products of 6419-36-9, Adding some certain compound to certain chemical reactions, such as: 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride,molecular formula is C7H8ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6419-36-9.

Compound 1 was prepared according to the method of a literature reported [28]. The pyrid-3-ylacetic acid hydrochloride (0.9g, 5.2mM) and triethylamine (1.4g, 13.1mM) were dissolved in dioxane (15mL), and the mixture was stirred at room temperature for about 10min. Then 1H-indole-3-carbaldehyde (0.5g, 3.5mM) and piperidine (0.6g, 15.2mM) were added, and the resulting mixture was stirred at reflux temperature for one day. After the reaction was completed, the solution was diluted with ethyl acetate, evaporated with silica and purified by flash chromatography to give the product. Yield: 1.06g (83%). 1H NMR (400MHz, DMSO-d6) delta 11.42 (s, 1H), 8.77 (d, J=2.1Hz, 1H), 8.38 (dd, J=4.7, 1.5Hz, 1H), 8.06 (d, J=7.8Hz, 1H), 8.02 (dt, J=8.0, 1.9Hz, 1H), 7.69 (d, J=2.6Hz, 1H), 7.57 (d, J=16.6Hz, 1H), 7.45 (d, J=8.0Hz, 1H), 7.36 (dd, J=7.9, 4.7Hz, 1H), 7.21-7.17 (m, 1H), 7.16-7.10 (m, 2H). HRMS (ESI) m/z calculated for C15H12N2 [M+H]+: 221.10375, found: 221.10375.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hua, Shixian; Wang, Xinyi; Chen, Feihong; Gou, Shaohua; Bioorganic Chemistry; vol. 92; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6419-36-9 , The common heterocyclic compound, 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-pyridyl acetate acid chloride (27 mg, 0.128 x 1.2 mmol) was dissolved in N.N-dimethylformamide (1 mL) under argon atmosphere, and cooled at 0 degree C. Triethylamine (21 mul, 0.128 x 1.2 mmol), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (29 mg, 0.128 x 1.2 mmol) and 1-hydroxybenzotriazol monohydrate (21 mg, 0.128 x1.2 mmol) were added, and stirred at 0 degree C for 30 minutes. 4-chloro deacetyl colchicine (50 mg, 0.128 mol) was added, and stirred at room temperature for 4 hours. Water was added and the reaction mixture was quenched, ethyl acetate was added, and washed with 10% aqueous-citric-acid solution, saturated sodium bicarbonate solution, and a saturated sodium chloride solution. The ethyl acetate layer was dried with anhydrous magnesium sulfate, and the solvent was distilled off. The obtained residue was purified by Silica gel chromatography (Biotage Isolera One, SNAP 10 g, methanol/chloroform) to obtain title compound (brown solid and 8 mg, 0.016 mmol, 11%).

The synthetic route of 6419-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHIBA UNIVERSITY; YAKULTHONSHA COMPANY LIMITED; TAKAYAMA, HIROMITSU; YASOBU, NAOKO; KITAJIMA, MARIKO; YAEGASHI, TAKASHI; MATSUZAKI, TAKESHI; NAGAOKA, MASATO; HASHIMOTO, SHUSUKE; NISHIYAMA, HIROYUKI; SUGIMOTO, TAKUYA; ONO, MASAHIRO; (176 pag.)JP5829520; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-(Pyridin-3-yl)acetic acid hydrochloride

Reference Example 3 N-[4-(2-Furyl)-5-(tetrahydropyran-4-carbonyl)thiazol-2-yl]-2-(pyridin-3-yl)acetamide (compound (IF)) 2-Amino-4-(2-furyl)thiazol-5-yl=tetrahydropyran-4-yl=ketone (105 mg, 0.377 mmol) described in was dissolved in DMF (2.0 mL), EDC hydrochloride (421 mg, 2.20 mmol), HOBt monohydrate (340 mg, 2.21 mmol) and 3-pyridylacetic acid hydrochloride (370 mg, 2.14mmol) were added thereto, and the mixture was stirred at 80C overnight. The mixture was allowed to cool to room temperature, and water and a saturated aqueous sodium hydrogen carbonate solution were added thereto. The precipitated solid was collected by filtration, and dried under reduced pressure. The obtained solid was purified by silica gel column chromatography (hexane:ethyl acetate=50:50), and recrystallized from ethanol-water to give compound (IF) (112 mg, 75%) as white crystals. 1H NMR (CDCl3, deltappm): 1.80-2.01 (m, 4H), 3.05-3.16 (m, 1H), 3.45 (ddd, J = 2.8, 11.4, 11.4 Hz, 2H), 3.81 (s, 2H), 3.97-4.06 (m, 2H), 6.54 (dd, J = 1.8, 3.6 Hz, 1H), 7.32 (dd, J = 7.8, 4.8 Hz, 1H), 7.52-7.54 (m, 1H), 7.62-7.68 (m, 2H), 8.55-8.64 (m, 2H), 9.21 (s, 1H). APCIMS m/z: [M+H]+ 398.

With the rapid development of chemical substances, we look forward to future research findings about 6419-36-9.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; KASE, Junya; KANDA, Tomoyuki; (28 pag.)EP2474544; (2017); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6419-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The 3-pyridine acetic acid hydrochloride obtained in step (4), phosphorous acid and chlorobenzene were added to a three – necked flask, and the amount ratio of the of the 3-pyridine acetic acid hydrochloride to phosphorous acid was 1:25 . The amount of chlorobenzene used was calculated according to the addition of 0.1 moles of 3-pyridine acetic acid hydrochloride per 100 mL of chlorobenzene. Reaction was stirr heated to reflux, dropping addition phosphorus trichloride, according to the ratio of the amount of 3-pyridine acetic acid hydrochloride and phosphorus trichloride was 1: 3 drop of phosphorus trichloride. After completion of the dropwise addition, the mixture was further refluxed for 7.5 hours, cooled to room temperature, and dumped chlorobenzene. The concentrated hydrochloric acid having a mass fraction of 37.5% and water was added to the residue , and 100 mL of concentrated hydrochloric acid and 50 mL of water were added per 100 mL of chlorobenzene, and refluxed for 7 hours. The activated charcoal was decolorized and filtered. The filtrate was concentrated to dryness under reduced pressure. The residue was added to absolute ethanol and 100 mL of anhydrous ethanol was added per 100 mL of chlorobenzene, precipitated large solid precipitation, and crushed into a powder. filtered, filter cake recrystallization with water, then drying at 80 C, to obtain white solid that is risedronic acid, the based on amount calculation of 3- Pyridine carbonyl chloride hydrochloride , the yield of risedronic acid was 60%.

According to the analysis of related databases, 6419-36-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Luohe Medical College; Ding Sujun; He Xinlei; Zhou Haiyang; Zhang Huifen; Li Pinai; (11 pag.)CN104628770; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6419-36-9

87 g 3-pyridineacetic acid hydrochloride (500 mmole) was suspended in 225 g chlorobenzene together with 103 g phosphorous trichloride (750 mmole) and heated to 50C for one hour to produce an opaque, 2 phase liquid system containing the acid chloride of 3- pyridineacetic acid.

With the rapid development of chemical substances, we look forward to future research findings about 6419-36-9.

Reference:
Patent; SANDOZ A/S; WO2008/58722; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6419-36-9 ,Some common heterocyclic compound, 6419-36-9, molecular formula is C7H8ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of l-(2-Phenylethyl)piperazine (2.2 ml, 11.5 mmol) and 3-pyridylacetic acid hydrochloride (2.0 g, 11.5 mmol) in DMF (approximately 15 ml) is added HOBT (1.6 g, 11.5 mmol). The pH of the solution is adjusted to 8 by adding N-methylmorpholine. Coupling reagent EDC (2.3 g, 11.9 mmol) is added. After the reaction mixture is stirred at RT over night, the solvent is evaporated under reduced pressure and the residue is dissolved in EtOAc (20 ml). The organic layer is washed with aqueous saturated NaHCO3 (20 ml) and NaCl (20 ml) solution and dried (Na2SO4). The solvent is evaporated under reduced pressure to give a product which is chromatographed on silica (MeOH/EtOAc, 2:10) to give a brownish solid; yield: 3.56 g, 100 % (98 % pure by area % HPLC analysis); mp 91-93 C; chemical formula: C19H23N3O; molecular weight: 309,41.1H NMR (300 MHz, DMSO-J15) delta 2.37 – 2.43 (4H, m), 2.50 – 2.54 (4H, m), 2.71 – 2.76 (2H, m), 3.40 – 3.54 (2H, m), 3.76 (2H, s), 7.18 – 7.35 (6H, m), 7.61 (IH, td, J= 7.8 Hz, J= 1.7), 8.42 – 8.44 (2H, m); FT-IR (NaCl) 3409, 2776, 1652, 1579, 1424, 1311, 1237, 1134, 1237, 1134, 998, 767, 697 cm”1; EI MS m/z 310 [MH+], FAB MS m/z 310 [MH+]; HRMS m/z calcd for C19H24N3O [MH+] 310.1919, found 310.1928.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LEK PHARMACEUTICALS D.D.; WO2007/73935; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 6419-36-9

5.159 N-[2-(2,6-DIOXO-PIPERIDIN-3-YL)-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YLMETHYL]-2-PYRIDINYL-3-YL-ACETAMIDE To a stirred suspension of 4-aminomethyl-2-(2,6-dioxo-piperidin-3-yl)-isoindole-1,3-dione hydrochloride (0.7 g, 2.2 mmol) in acetonitrile (60 mL), was added 1,8-diazabicyclo[5,4,0]undec-7-ene (0.8 g, 5.4 mmol). After stirring for 10 minutes, 1-hydroxybenzotriazole (0.4 g, 2.6 mmol) and 3-pyridylacetic acid hydrochloride (0.4 g, 2.4 mmol) were added, followed by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.6 g, 3.2 mmol). The mixture was stirred at room temperature overnight then was concentrated in vacuo. The residue was dissolved in CH2Cl2 (80 mL) and washed with water (3¡Á40 mL) and brine (40 mL), and dried over MgSO4. Solvent was removed in vacuo, and residue was purified by ISCO silica gel flash chromatography (Eluent: CH3OH:CH2Cl2 3:97) to afford N-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-2-pyridinyl-3-yl-acetamide (0.5 g, 57%) as a white solid: mp 292-294 C.; HPLC: Waters Symmetry C-18, 3.9¡Á150 mm, 5 micro, 1 mL/min, 240 nm, 40/60 (CH3CN/H2O): tR=0.87 min. (97%); 1H NMR (DMSO-d6) delta 2.04-2.07 (m, 1H), 2.52-2.63 (m, 2H), 2.84-2.96 (m, 1H), 3.59 (s, 2H), 4.74 (d, J=5.8 Hz, 2H), 5.12-5.18 (dd, J=5.2 and 12.7 Hz, 1H), 7.32-7.36 (m, 1H), 7.65-7.71 (m, 2H), 7.80-7.84 (m, 2H), 8.43-8.49 (m, 2H), 8.75 (t, J=5.8 Hz, 1H), 11.14 (s, 1H); 13C NMR (DMSO-d6) delta 21.95, 30.90, 37.89, 39.03, 48.83, 121.93, 123.33, 127.15, 131.52, 131.79, 133.26, 134.70, 136.64, 138.97, 147.65, 150.01, 166.89, 167.41, 169.78, 170.03, 172.73; Anal. Calcd. for C21H18N4O5: C, 62.07; H, 4.46; N, 13.79. Found: C, 61.73; H, 4.46; N, 13.55.

Statistics shows that 6419-36-9 is playing an increasingly important role. we look forward to future research findings about 2-(Pyridin-3-yl)acetic acid hydrochloride.

Reference:
Patent; Muller, George W.; Chen, Roger Shen-Chu; Man, Hon-Wah; Ruchelman, Alexander L.; US2007/49618; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

6419-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 3; Preparation of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid monosodium salt in the presence of olive oil; The procedure of Example I is repeated except olive oil is used as the emulsifying agent instead of sunflower oil. The analysis confirmed the identity of the product and the absence of impurities. Overall yield of 27.0 % is obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S.; EP1798236; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 6419-36-9

To a solution of (S)-((3R,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl) 5,6-bis(nitrooxy)hexanoate (Example 1, Step 8) (100 mg, 0.273 mmol) in dry DCM (3 ml), DMAP (73 mg, 0.601 mmol), DCC (112 mg, 0.546 mmol) and 3-pyridylacetic acid hydrochloride (57 mg, 0.328 mmol) were added. The mixture was stirred overnight at room temperature, then DMAP (73 mg, 0.601 mmol) and 3-pyridylacetic acid hydrochloride (57 mg, 0.328 mmol) were added. The mixture was allowed to stir for 4 hours. The solid was filtered off, water and DCM were added, the two phases were separated and the aqueous phase extracted twice with DCM. The combined organic phases were dried over MgS04 and concentrated under reduced pressure. The residue was purified by reversed-phase chromatography (H20/CH3CN from 95:5 to 30:70), to give 58 mg of the desired product (yield: 43.8%). NMR (600 MHz, DMSO-d6) delta 8.49 – 8.46 (m, 2Eta), 7.72 – 7.68 (m, IH), 7.38 – 7.34 (m, IH), 5.45 – 5.40 (m, IH), 5.05 (q, IH), 4.97 (q, IH), 4.93 (dd, IH), 4.71 (dd, IH), 4.64 – 4.58 (m, 2H), 3.92 (dd, IH), 3.87 (dd, IH), 3.79 (s, 2H), 3.68 (dd, IH), 3.56 (dd, IH), 2.41 (t, 2H), 1.80 – 1.72 (m, 2H), 1.68 – 1.60 (m, 2H).

Statistics shows that 6419-36-9 is playing an increasingly important role. we look forward to future research findings about 2-(Pyridin-3-yl)acetic acid hydrochloride.

Reference:
Patent; NICOX S.A.; ALMIRANTE, Nicoletta; BRAMBILLA, Stefania; STORONI, Laura; BASTIA, Elena; (47 pag.)WO2018/224419; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

6419-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

D56Pyridin-3-yI-acetic acid ethyl esterTo a solution of 3-pyridylacetic acid hydrochloride (40g, 230.41mmol) in ethanol (90 mL) was added sulfuric acid(73 g, 744.3 mmole, 98%) under N2. The reaction mixture was refluxed for 4 h, then cooled to rt. Ammonium hydroxide (250 mL, 25%) was added and extracted with DCM (500 mL) twice, dried over sodium sulfate, concentrated to afford the title product (33 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride.

Reference:
Patent; GLAXO GROUP LIMITED; WAN, Zehong; ZHANG, XIaomin; WANG, Jian; PENG, Cheng; JIN, Yun; HU, Yimin; WO2012/75917; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem