Category: 6419-36-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride. A new synthetic method of this compound is introduced below., 6419-36-9

Example C2 Synthesis of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic Acid In a 100 ml rounded bottom, three necked flask equipped with a magnetic stirrer, a thermometer, a reflux condenser and a compensated-pressure dropping funnel were charged: 1.00 g (5.76¡¤10-3 mol) of 3-pyridyl acetic acid hydrochloride, 1.46 g (1.78¡¤10-2 mol) of phosphonic acid, 3.01 g (1.72¡¤10-2 mol) of methanesulfonic anhydride and 7.2 ml of toluene. 1.22 g of PCl5 was steeply added at room temperature. Exothermy, gas evolution and foaming was observed. The mixture was then heated up to 95 C. At about 40 C., formation of two well defined liquid phases were observed. The mixture was kept overnight at 95 C. No stirring problems arose. The mixture was then let to cool down to 80 C. at which point 7.2 ml of water were added dropwise (exothermy was observed). The mixture was stirred at 80 C. for 15 minutes and then let to cool down to room temperature. The aqueous layer was decanted and heated to 95 C. for 5.5 h and let to cool down to room temperature, at which point 7.2 ml of ethanol were added. The resulting mixture was cooled down to 5 C., stirred for 1 h and filtered. The solid washed with ethanol and dried at 40 C. in a vacuum oven until constant weight. 1.01 g of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid monohydrate are obtained (Yield: 58.23%) Chromatographic purity: 98.327% (area percent)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Serrano, Jordi Puig; Illado, Jordi Bosch; US2008/194525; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6419-36-9, blongs to pyridine-derivatives compound. 6419-36-9

HATU (41.6 mg, 0.11 mmol) was added to a solution of DIEA (0.048 mL, 0.27 mmol), 2-(pyridin-3-yl)acetic acid hydrochloride (18.98 mg, 0.11 mmol) and (R)-N-(3,5-difluoro-4-(2-methyl-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)phenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide hydrochloride (45 mg, 0.09 mmol) in DMF (2 mL) at room temperature, and the mixture was stirred overnight at room temperature. To the reaction mixture was added aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 0?25% MeOH/ethyl acetate) to give the title compound (33.0 mg, 0.057 mmol, 62.8%) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6419-36-9, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YAMAMOTO, SATOSHI; SHIRAI, JUNYA; WATANABE, HIROYUKI; FUKUMOTO, SHOJI; ODA, TSUNEO; TOKUHARA, HIDEKAZU; TOMATA, YOSHIHIDE; ISHII, NAOKI; TAWADA, MICHIKO; KOUNO, MITSUNORI; OCHIDA, ATSUKO; IMADA, TAKASHI; FUKASE, YOSHIYUKI; YUKAWA, TOMOYA; (719 pag.)TW2016/2105; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

6419-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1-Preparation of risedronic acid A mixture of (3-pyridyl) acetic acid hydrochloride (10 g 0.06 moles) and phosphorous acid (47 g, 0.58 moles) is slowly added with phosphorus oxychloride (28.8 g 0.19 moles). The fluid mixture is warmed up to 60-70C for 24 hours, then added with 60 ml water at the same temperature. The mixture is refluxed for 6 hours, added with 0.3 g charcoal and hot-filtered through celite. The clarified solution is added with 160 ml acetone. The resulting precipitate is filtered, suspended in 50 ml water, dissolved at pH 7.5 (+/-0.2) with 30% sodium hydroxide. The resulting solution is acidified to pH 0.8 (+/-0. 2) and the precipitate is filtered and dried under vacuum at 40-50C to constant weight. 9. 8 g pure risedronic acid is obtained (yield: 60%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LYOGEN LIMITED; WO2005/63779; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem