Category: 6443-85-2

Electric Literature of 6443-85-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6443-85-2, name is 2-(Pyridin-3-yl)acetonitrile, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

Example 1A trans-2-(3-Pyridyl)-3-(3,5-dichlorophenyl)-2-propenenitrile To a stirred solution of 400 g (2.3 mole) 3,5-dichlorobenzaldehyde in 11.4 liters absolute ethanol were added 283.5 g (2.4 mole) 3-pyridylacetonitrile and 720.9 g of K2 CO3. Within 2 minutes of the K2 CO3 addition, a solid precipitate formed. The reaction mixture was stirred about 2.5 hours. Water (22.9 liters) was added to the stirred reaction mixture. After stirring for 1 hour, the mixture was filtered and the filter cake was washed with water (10 liters), dried and recrystallized from isopropanol. Five hundred thirty four g (85% yield) of trans-2-(3-pyridyl)-3-(3,5-dichlorophenyl)-2-propenenitrile were obtained, m.p. 150-151 C.

The chemical industry reduces the impact on the environment during synthesis 6443-85-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Rhone-Poulenc Rorer International (Holdings) Inc.; US5418245; (1995); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6443-85-2, Adding some certain compound to certain chemical reactions, such as: 6443-85-2, name is 2-(Pyridin-3-yl)acetonitrile,molecular formula is C7H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6443-85-2.

EXAMPLE 8 (Z)-3-(9-Ethyl-9H-carbazol-3-yl)-2-(pyridin-3-yl) acrylonitrile 9-Ethyl-9H-carbazol-3-yl-carboxaldehyde (4.46 g; 0.02 mol) and 3-pyridylacetonitrile (2.36 g; 0.02 mol) were dissolved in ethanol (25 mL). Sodium methoxide (1 mL of 25% methanol solution) was added. The mixture was then left standing at ambient temperature for 24 hours. The formed precipitate was collected by filtration and dried to give 2.4 g (37% yield) of the title compound as a yellow solid, m.p. 131-133 C. Anal. Calcd. for C22 H17 N3: C, 81.71; H, 5.30; N, 12.99. Found: C, 81.38; H. 5.49; N, 12.84. Mass spectrum (EI; M+) m/z 323. 1 H-NMR (DMSO-d6; 400 MHz) delta 8.98 (d, 1H), 8.75 (d, 1H), 8.60 (dd, 1H), 8.28 (s, 1H)1, 8.18 (dd, 1H), 8.12-8.16 (m, 2H), 7.8 (d, 1H), 7.68 (d, 1H), 7.51-7.56 (m, 2H), 7.29 (t, 1H), 4.49 (q, 2H), and 1.34 ppm (t, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6443-85-2, 2-(Pyridin-3-yl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; American Home Products Corporation; US5710164; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6443-85-2, name is 2-(Pyridin-3-yl)acetonitrile, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.Formula: C7H6N2

54.1 Synthesis of 3-cyano-3-(pyridin-3-yl)-pentanedioic acid diethyl ester Prepare by the method of example 1.1.2 using pyridin-3-yl-acetonitrile (0.161 mol) and ethyl bromoacetate (0.325 mol). Chromatograph on silica gel to give the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6443-85-2, 2-(Pyridin-3-yl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Merrell Pharmaceuticals Inc.; US5635510; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6443-85-2 ,Some common heterocyclic compound, 6443-85-2, molecular formula is C7H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a Schlenk tube,116 mg (0.151 mmol) of 1 was dissolved in 10 mL of CH2Cl2, resulting in a bright-red solution. 160 muL (179 mg, 1.51 mmol) of 3-pyridylacetonitrile (3-Py-CH2CN) was syringed into the solution, and the reaction mixture was stirred at room temperature for 7 h. After this time, the solvent was evaporated to dryness and the solid residue was washed three times with hexane. The final product was characterized as 2. Yield: 100.8 mg, 0.139 mM,92%. IR (ATR): nu 2535vs (BH), 2511vs (BH), 2460vs (BH), 2255w (CN), and 2060m(RhH). 11B-{1H} NMR (128 MHz; CD2Cl2; 298 K): delta + 12.1, +7.8, +3.5, +0.3, -3.8, -9.9,-18.5, -25.6, and -29.6. 1H NMR (500 MHz; CD2Cl2; 298 K): delta + 7.91 (1H, br,3-PyCH2CN), +7.82 (1H, br, 3-PyCH2CN), +7.35 – +7.05 (aromatics, PPh3), +4.04 (v br,BH), +3.67 (ABq, 1H, DeltanuAB = 30.8 Hz, JAB = 19.2 Hz, CH2CN), +3.55 (ABq, CH2CN),+2.85 (v br, BH), +1.84 (v br, BH), -1.37 (br s, BHB), and -12.51 (apparent q, J = 18.9 Hz, RhH); due to the insolubility of the compound, the terminal B-H peakscould not be observed. 31P-{1H} NMR (121 MHz; CD2Cl2; 213 K): delta + 36.3 (dd,JRhP = 104.1 Hz) and + 30.4 (dd, JRhP = 127.1 Hz, 2JPP = 19 Hz). LRMS (MALDI+/DCTB): m/z [2M-3(PPh3)-4H]+ obsvd 979, Calcd for P1C32H43Rh2S2B18N4: 979; [M-PPh3-2H]+ obsvd 621, Calcd for P1C25H29Rh1S1B9N2: 621. The obsvd isotope envelope matchesthat calculated from the known isotopic abundances of the constituent elements.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6443-85-2, its application will become more common.

Reference:
Article; Calvo; Kess; Macias; Sancho; Lahoz; Oro; Journal of Coordination Chemistry; vol. 67; 23-24; (2014); p. 4016 – 4027;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 6443-85-2 ,Some common heterocyclic compound, 6443-85-2, molecular formula is C7H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 2-(pyridin-3-yl)acetonitrile (1 g, 8.47 mmol, 1.00 equiv), Raney nickel (1 g, 17.24 mmol, 1.00 equiv) and ammonium hydroxide (3 mL) in methanol (15 mL) was stirred under 1 atmosphere of hydrogen at room temperature overnight. The catalyst was removed by filtration through a pad of Celite and washed with several portions of methanol. The filtrate and washings were combined and concentrated under vacuum to give 940 mg (45%) of 2-(pyridin-3-yl)ethanamine as a yellow oil. LC-MS: (ES, m/z): 164 [M+CH3CN+H]+, 123 [M+H]+, 106.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6443-85-2, 2-(Pyridin-3-yl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Board of Trustees of the Leland Stanford Junior University; Auckland UniServices Limited; Ruga Corporation; Giaccia, Amato; Lai, Edwin; Razorenova, Olga; Chan, Denise; Hay, Michael Patrick; Bonnet, Muriel; Sun, Connie; Tabibiazar, Ray; Yuen, Po-wai; US2015/329503; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6443-85-2, 2-(Pyridin-3-yl)acetonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6443-85-2, blongs to pyridine-derivatives compound. Quality Control of 2-(Pyridin-3-yl)acetonitrile

b) 2-(3-pyridyl)ethylamine dihydrochloride was prepared as follows. A mixture of 1.3 g 3-pyridylacetonitrile, approximately 3 g Raney nickel and 30 ml methanol containing 10% ammonia by volume was hydrogenated at 35 psi for 20 hr using a Parr hydrogenator. The catalyst was filtered off over celite and the filtrate was evaporated. The residue was dissolved in methylene chloride, dried with magnesium sulfate, filtered and evaporated. The product was converted to the dihydrochloride using hydrogen chloride in dioxane. Crystallization from methanol/ether gave 1.4 g colorless crystals having a mp 145-148 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6443-85-2, its application will become more common.

Reference:
Patent; Aventis Pharmaceuticals Inc.; US6759384; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6443-85-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6443-85-2, name is 2-(Pyridin-3-yl)acetonitrile. A new synthetic method of this compound is introduced below.

54.1.1 Synthesis of 3-cyano-3-(pyridin-3-yl)-pentanedioic acid diethyl ester Prepare by the method of example 1.1.2 using pyridin-3-yl-acetonitrile (0.161 mol) and ethyl bromoacetate (0.325 mol). Chromatograph on silica gel to give the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6443-85-2, 2-(Pyridin-3-yl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Hoechst Marion Roussel Inc.; US5824690; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

6443-85-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6443-85-2, name is 2-(Pyridin-3-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows.

34.1.2 Synthesis of 3-cyano-3-(pyrid-3-yl)pentanedioic acid diethyl ester Combine 3-pyridineacetonitrile (25 g, 212 mmol) and tetrahydrofuran (200 mL). Cool to about -70 C. using a dry-ice/acetone bath. Add dropwise, a solution of sodium bis(trimethylsilyl)amide (435 mL, 1 M in tetrahydrofuran, 435 mmol) while maintaining the reaction temperature below about -68 C. When the addition is complete, warm the reaction mixture to ambient temperature and allow to stir for 1 hour. Transfer the above solution via cannula into a cooled (-5 C.) solution of ethyl bromoacetate (84.5 mL, 762 mmol) in tetrahydrofuran (500 mL) at such a rate that the temperature of the reaction mixture does not rise above about 15 C. Allow to stir at ambient temperature. After 18 hours, quench with saturated aqueous solution of ammonium chloride and evaporate in vacuo to remove most of the tetrahydrofuran. Extract the evaporated reaction mixture twice with diethyl ether. Dry the organic layer over MgSO4, filter, and concentrate in vacuo to obtain a residue. Chromatograph the residue on silica gel eluding with 1/1 ethyl acetate/hexane to give the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6443-85-2, 2-(Pyridin-3-yl)acetonitrile.

Reference:
Patent; Aventis Pharmaceuticals Inc.; US6194406; (2001); B1;; ; Patent; Aventis Pharmaceuticals Inc.; US6423704; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem