On October 12, 1977, Schmidtchen, Franz P.; Rapoport, Henry published an article.Reference of 2-Bromo-5,6-dimethoxy-3-methylpyridine The title of the article was Polyprenylpyridinols. Synthesis of piericidin analogs. And the article contained the following:
The piericidin A analogs I (n = 1, 2, 3, 9) and II were prepared for structure-activity studies on coenzyme Q inhibitors. To prepare the nucleus, 3-methoxyacetylamino-2-methylacrylonitrile was cyclized to a 4-amino-2-pyridone which Me3O+ BF4- converted to the 4-amino-2,3-dimethoxypyridine. Bromination of the acylated amine formed the 6-bromo derivative in which the 4-amino group was then replaced by hydroxy and the latter blocked by conversion to its benzyl ether with a benzylisourea. Transmetalation now gave the 6-lithio compound which was coupled with various prenyl bromides, leading to introduction of all trans polyprenyl side chains. The final 4-pyridinols were formed on selective debenzylation with butyl mercaptide. All the polyprenylpyridinols inhibited coenzyme Q electron transport to some extent, with the farnesyl analog having the same activity as piericidin A. The experimental process involved the reaction of 2-Bromo-5,6-dimethoxy-3-methylpyridine(cas: 64837-91-8).Reference of 2-Bromo-5,6-dimethoxy-3-methylpyridine
The Article related to piericidin a analog synthesis, pyridinol polypropenyl, prenylpyridinol preparation coenzyme q inhibitor, coenzyme q inhibitor, polyprenylpyridinol preparation coenzyme inhibitor and other aspects.Reference of 2-Bromo-5,6-dimethoxy-3-methylpyridine