Category: 64951-08-2

Adding a certain compound to certain chemical reactions, such as: 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Imidazo[1,2-a]pyridine-2-carboxylic acid, blongs to pyridine-derivatives compound. Application In Synthesis of Imidazo[1,2-a]pyridine-2-carboxylic acid

To a solution of 23-1 (O.lg, 0.7mmol) in EtOH (15ml) in a dried flask was added Pt2O (O. Ig, 0.4mmol). The reaction mixture was placed under a nitrogen atmosphere and was subsequently evacuated. This was repeated 3 times before placing the reaction mixture under an atmosphere of hydrogen. After 3h the reaction mixture was filtered through celite. Upon solvent removal the desired product 23-2 was obtained as an off-white powder. MS calculated M+H: 167.2, found 167.1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 64951-08-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of imidazo[l ,2- a]pyridine-2-carboxylic acid (5.89 g, 36.60 mmol) in dichloromethane (350 mL) was added bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) (9.3 g, 36.6 mmol) and the mixture was stirred at room temperature for 4 hours. Triethylamine (15.0 mL) and 4-(4-(2-(tert-butyl)-6- (trifluoromethyl)pyrimidin-4-yl)piperazin-l-yl)butan-l -amine (13.14 g , 36.6 mmol) were added and the mixture was stirred at room temperature overnight . The reaction mixture was concentrated under reduced pressure and the residue was partitioned between EtOAc and water. The organic layers were dried over anhydrous sodium sulfate, filtered and the filtrate was evaporated under reduced pressure. The residue obtained was purified by column chromatography over silica using EtOAc-MeOH (10: 1) as the eluent to yield 6.0 g (32%) of the desired product. A solution of the free base in ether was treated with 1.0 molar solution of HCl in diethyl ether to obtain the dihydrochloride salt, mp 253-255 C. TLC Rf 0.29 (CHCl3-MeOH, 90: 10); 1H NMR (DMSO-d6) delta 1.31 (s, 9H), 1.62-1.69 (m, 2H), 1.80-1.88 (m, 2H), 2.88-3.19 (broad hump, 1H), 3.10-3.17 (m, 2H), 3.37-3.33 (q, 2H), 3.52-3.60 (m, 4H), 4.32-4.86 (b, 2H), 7.1 1 (s, 1H), 7.13-7.18 (m, 1H), 7.50-7.57 (t, 1H), 7.65 (dd, J = 9.2, 9.0 Hz, 1H), 8.53 (s, 1H), 8.57 (bs, 1H), 8.68 (d, J= 6.9 Hz, 1H), 1 1.0-1 1.8 (b, 1H). ESI MS m/z 504 (MH)+. Anal. (C25H32F3N7O-2HCl-0.25H2O) Calcd: C, 51.68; H, 5.98; N, 16.87.C1, 12.20. Found: C, 51.64; H, 6.00; N, 16.89, CI, 1 1.97

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid.

Reference:
Patent; SOUTHERN RESEARCH INSTITUTE; ANANTHAN, Subramaniam; WO2014/59265; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Imidazo[1,2-a]pyridine-2-carboxylic acid

To a solution of 23-1 (O.lg, 0.7mmol) in EtOH (15ml) in a dried flask was added Pt2O (O. Ig, 0.4mmol). The reaction mixture was placed under a nitrogen atmosphere and was subsequently evacuated. This was repeated 3 times before placing the reaction mixture under an atmosphere of hydrogen. After 3h the reaction mixture was filtered through celite. Upon solvent removal the desired product 23-2 was obtained as an off-white powder. MS calculated M+H: 167.2, found 167.1

With the rapid development of chemical substances, we look forward to future research findings about 64951-08-2.

Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Imidazo[1,2-a]pyridine-2-carboxylic acid, blongs to pyridine-derivatives compound. Application In Synthesis of Imidazo[1,2-a]pyridine-2-carboxylic acid

To a solution of 23-1 (O.lg, 0.7mmol) in EtOH (15ml) in a dried flask was added Pt2O (O. Ig, 0.4mmol). The reaction mixture was placed under a nitrogen atmosphere and was subsequently evacuated. This was repeated 3 times before placing the reaction mixture under an atmosphere of hydrogen. After 3h the reaction mixture was filtered through celite. Upon solvent removal the desired product 23-2 was obtained as an off-white powder. MS calculated M+H: 167.2, found 167.1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 64951-08-2, blongs to pyridine-derivatives compound. category: pyridine-derivatives

To a solution of carboxylic acid (1.1 g, 7 mmol) in dry DCM (10 mL) at 0C under nitrogen was added B (1.5 mg, 7 mmol), Et3N (2.1 g, 21 mmol), EDCI (4.7 g, 23.8 mmol), HOBt (2.8 g, 21 mmol) and DMAP (150 mg, catalytic). Reaction mixture was stirred at 25C for 2-12 h, monitored by TLC. Mixture was poured into cold water (10 ml) and extracted with DCM (20ml), washed with water and brine, then dried and concentrated. Crude material was purified by column chromatography (silica gel, EtOAc_PE=l :2) to give C (751 mg, 30%) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,64951-08-2, its application will become more common.

Reference:
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; THE SCRIPPS RESEARCH INSTITUTE; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; CHATTERJEE, Arnab, K.; WANG, Feng; SCHULTZ, Peter, G.; XU, Chunping; AJAYI, Kehinde; WANG, Jianing; HALDER, Rajkumar; KUMAR, Puneet; YANG, Baiyuan; LIU, Renhe; CHENG, Bo; KANEKO, Takushi; WO2014/190199; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 64951-08-2

To a solution of imidazo[l,2-a]pyridine-2-carboxylic acid (262 mg, 1.62 mmol) in N,N-dimethylformamide (5 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU, 616 mg, 1.62 mmol), ethyldiisopropylamine (697mg, 5.40 mmol). The resulting mixture was stirred at room (0804) temperature for 30 min. Ethyl 2-((2S,4tf)-4-((((9H-fluoren-9-yl) (0805) methoxy)carbonyl)amino)pyrrolidin-2-yl)thiazole-4-carboxylate (500 mg, 1.08 mmol) was added. The mixture was stirred at room temperature for 12 h. The mixture was concentrated, dissolved in ethyl acetate, washed with 1 N lithium chloride. The organic layer was concentrated to give ethyl 2-((2S,4 ?)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-l-(imidazo[l,2- a]pyridine-2-carbonyl)pyrrolidin-2-yl)thiazole-4-carboxylate as a brown solid. MS(ESI) m/z 608.2 [M + H]+.

With the rapid development of chemical substances, we look forward to future research findings about 64951-08-2.

Reference:
Patent; DYAX CORP.; TRAVINS, Jeremy; MILLER, Thomas; PAPAIOANNOU, Nikolaos; (199 pag.)WO2019/28362; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: Imidazo[1,2-a]pyridine-2-carboxylic acid

Step (e) N-{4-[6-fluoro-2,4-dioxo-l-[3-(pyridin-3-ylethynyl)phenyl]-l,4- dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]cyclohexyl}imidazo[l,2-a]pyridine-2- carboxamideTo a mixture of imidazo[l,2-a]pyridine-2-carboxylic acid (1 lOmg, 0.68mmol), HATU (250mg, 0.66mmol) and 3-(4-aminocyclohexyl)-6-fluoro-l-[3-(pyridin- 3ylethynyl)phenyl]-pyrido[2,3-d]pyrimidine-2,4(lH,3H)-dione dihydrochloride (230mg, 0.44mmol) in Chloroform was added ethyl-di-isopropylamine (0.38ml, 2.2mmol) over a period of 20 seconds. Stirring was continued at ambient temperature for 15 hours. Water was added to the clear solution and the mixture was concentrated under reduced pressure using a rotary evaporator. The obtained solid was filtered and dissolved in acetonitrile. Purification on preparative HPLC resulted in the title compounds as an off white solid (45mg, 17%). 1U NMR (DMSO-ck): delta 8.75 (IH, s); 8.55 – 8.62 (3H, m); 8.38 (IH, s); 8.34 (IH, dd); 7.98 (IH, ddd); 7.57 – 7.74 (4H, m); 7.44 – 7.52 (2H, m); 7.33 (IH, brdd); 6.98 (IH, brdd); 4.87 (IH, bt); 4.18 (IH, bs); 2.54 – 2.69 (2H, brm); 2.00 (2H, brd); 1.59 – 1.79 (4H, m). APCI-MS m/z: 599 [MH+].

With the rapid development of chemical substances, we look forward to future research findings about 64951-08-2.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/84223; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 64951-08-2, blongs to pyridine-derivatives compound. category: pyridine-derivatives

To a solution of carboxylic acid (1.1 g, 7 mmol) in dry DCM (10 mL) at 0C under nitrogen was added B (1.5 mg, 7 mmol), Et3N (2.1 g, 21 mmol), EDCI (4.7 g, 23.8 mmol), HOBt (2.8 g, 21 mmol) and DMAP (150 mg, catalytic). Reaction mixture was stirred at 25C for 2-12 h, monitored by TLC. Mixture was poured into cold water (10 ml) and extracted with DCM (20ml), washed with water and brine, then dried and concentrated. Crude material was purified by column chromatography (silica gel, EtOAc_PE=l :2) to give C (751 mg, 30%) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,64951-08-2, its application will become more common.

Reference:
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; THE SCRIPPS RESEARCH INSTITUTE; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; CHATTERJEE, Arnab, K.; WANG, Feng; SCHULTZ, Peter, G.; XU, Chunping; AJAYI, Kehinde; WANG, Jianing; HALDER, Rajkumar; KUMAR, Puneet; YANG, Baiyuan; LIU, Renhe; CHENG, Bo; KANEKO, Takushi; WO2014/190199; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 64951-08-2

To a solution of imidazo[l,2-a]pyridine-2-carboxylic acid (262 mg, 1.62 mmol) in N,N-dimethylformamide (5 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU, 616 mg, 1.62 mmol), ethyldiisopropylamine (697mg, 5.40 mmol). The resulting mixture was stirred at room (0804) temperature for 30 min. Ethyl 2-((2S,4tf)-4-((((9H-fluoren-9-yl) (0805) methoxy)carbonyl)amino)pyrrolidin-2-yl)thiazole-4-carboxylate (500 mg, 1.08 mmol) was added. The mixture was stirred at room temperature for 12 h. The mixture was concentrated, dissolved in ethyl acetate, washed with 1 N lithium chloride. The organic layer was concentrated to give ethyl 2-((2S,4 ?)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-l-(imidazo[l,2- a]pyridine-2-carbonyl)pyrrolidin-2-yl)thiazole-4-carboxylate as a brown solid. MS(ESI) m/z 608.2 [M + H]+.

With the rapid development of chemical substances, we look forward to future research findings about 64951-08-2.

Reference:
Patent; DYAX CORP.; TRAVINS, Jeremy; MILLER, Thomas; PAPAIOANNOU, Nikolaos; (199 pag.)WO2019/28362; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: Imidazo[1,2-a]pyridine-2-carboxylic acid

Step (e) N-{4-[6-fluoro-2,4-dioxo-l-[3-(pyridin-3-ylethynyl)phenyl]-l,4- dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]cyclohexyl}imidazo[l,2-a]pyridine-2- carboxamideTo a mixture of imidazo[l,2-a]pyridine-2-carboxylic acid (1 lOmg, 0.68mmol), HATU (250mg, 0.66mmol) and 3-(4-aminocyclohexyl)-6-fluoro-l-[3-(pyridin- 3ylethynyl)phenyl]-pyrido[2,3-d]pyrimidine-2,4(lH,3H)-dione dihydrochloride (230mg, 0.44mmol) in Chloroform was added ethyl-di-isopropylamine (0.38ml, 2.2mmol) over a period of 20 seconds. Stirring was continued at ambient temperature for 15 hours. Water was added to the clear solution and the mixture was concentrated under reduced pressure using a rotary evaporator. The obtained solid was filtered and dissolved in acetonitrile. Purification on preparative HPLC resulted in the title compounds as an off white solid (45mg, 17%). 1U NMR (DMSO-ck): delta 8.75 (IH, s); 8.55 – 8.62 (3H, m); 8.38 (IH, s); 8.34 (IH, dd); 7.98 (IH, ddd); 7.57 – 7.74 (4H, m); 7.44 – 7.52 (2H, m); 7.33 (IH, brdd); 6.98 (IH, brdd); 4.87 (IH, bt); 4.18 (IH, bs); 2.54 – 2.69 (2H, brm); 2.00 (2H, brd); 1.59 – 1.79 (4H, m). APCI-MS m/z: 599 [MH+].

With the rapid development of chemical substances, we look forward to future research findings about 64951-08-2.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/84223; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem