Category: 64951-08-2

Adding a certain compound to certain chemical reactions, such as: 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 64951-08-2, blongs to pyridine-derivatives compound. category: pyridine-derivatives

To a solution of carboxylic acid (1.1 g, 7 mmol) in dry DCM (10 mL) at 0C under nitrogen was added B (1.5 mg, 7 mmol), Et3N (2.1 g, 21 mmol), EDCI (4.7 g, 23.8 mmol), HOBt (2.8 g, 21 mmol) and DMAP (150 mg, catalytic). Reaction mixture was stirred at 25C for 2-12 h, monitored by TLC. Mixture was poured into cold water (10 ml) and extracted with DCM (20ml), washed with water and brine, then dried and concentrated. Crude material was purified by column chromatography (silica gel, EtOAc_PE=l :2) to give C (751 mg, 30%) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,64951-08-2, its application will become more common.

Reference:
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; THE SCRIPPS RESEARCH INSTITUTE; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; CHATTERJEE, Arnab, K.; WANG, Feng; SCHULTZ, Peter, G.; XU, Chunping; AJAYI, Kehinde; WANG, Jianing; HALDER, Rajkumar; KUMAR, Puneet; YANG, Baiyuan; LIU, Renhe; CHENG, Bo; KANEKO, Takushi; WO2014/190199; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 64951-08-2

To a solution of imidazo[l,2-a]pyridine-2-carboxylic acid (262 mg, 1.62 mmol) in N,N-dimethylformamide (5 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU, 616 mg, 1.62 mmol), ethyldiisopropylamine (697mg, 5.40 mmol). The resulting mixture was stirred at room (0804) temperature for 30 min. Ethyl 2-((2S,4tf)-4-((((9H-fluoren-9-yl) (0805) methoxy)carbonyl)amino)pyrrolidin-2-yl)thiazole-4-carboxylate (500 mg, 1.08 mmol) was added. The mixture was stirred at room temperature for 12 h. The mixture was concentrated, dissolved in ethyl acetate, washed with 1 N lithium chloride. The organic layer was concentrated to give ethyl 2-((2S,4 ?)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-l-(imidazo[l,2- a]pyridine-2-carbonyl)pyrrolidin-2-yl)thiazole-4-carboxylate as a brown solid. MS(ESI) m/z 608.2 [M + H]+.

With the rapid development of chemical substances, we look forward to future research findings about 64951-08-2.

Reference:
Patent; DYAX CORP.; TRAVINS, Jeremy; MILLER, Thomas; PAPAIOANNOU, Nikolaos; (199 pag.)WO2019/28362; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: Imidazo[1,2-a]pyridine-2-carboxylic acid

Step (e) N-{4-[6-fluoro-2,4-dioxo-l-[3-(pyridin-3-ylethynyl)phenyl]-l,4- dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]cyclohexyl}imidazo[l,2-a]pyridine-2- carboxamideTo a mixture of imidazo[l,2-a]pyridine-2-carboxylic acid (1 lOmg, 0.68mmol), HATU (250mg, 0.66mmol) and 3-(4-aminocyclohexyl)-6-fluoro-l-[3-(pyridin- 3ylethynyl)phenyl]-pyrido[2,3-d]pyrimidine-2,4(lH,3H)-dione dihydrochloride (230mg, 0.44mmol) in Chloroform was added ethyl-di-isopropylamine (0.38ml, 2.2mmol) over a period of 20 seconds. Stirring was continued at ambient temperature for 15 hours. Water was added to the clear solution and the mixture was concentrated under reduced pressure using a rotary evaporator. The obtained solid was filtered and dissolved in acetonitrile. Purification on preparative HPLC resulted in the title compounds as an off white solid (45mg, 17%). 1U NMR (DMSO-ck): delta 8.75 (IH, s); 8.55 – 8.62 (3H, m); 8.38 (IH, s); 8.34 (IH, dd); 7.98 (IH, ddd); 7.57 – 7.74 (4H, m); 7.44 – 7.52 (2H, m); 7.33 (IH, brdd); 6.98 (IH, brdd); 4.87 (IH, bt); 4.18 (IH, bs); 2.54 – 2.69 (2H, brm); 2.00 (2H, brd); 1.59 – 1.79 (4H, m). APCI-MS m/z: 599 [MH+].

With the rapid development of chemical substances, we look forward to future research findings about 64951-08-2.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/84223; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 64951-08-2, Adding some certain compound to certain chemical reactions, such as: 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid,molecular formula is C8H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64951-08-2.

Step (b) N-(2-aminoethyl)-N-{cis-4-[6-fluoro-2,4-dioxo-l-(tetrahydro-2H-thiopyran-4-yl)- l,4-dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]cyclohexyl}imidazo[l,2-a]pyridine-2- carboxamide.; Imidazole[l,2a]pyridine-2-carboxylic acid (72 mg, 0.43 mmol) was dissolved in dry DMF (5 ml) and DIEA (0.2 ml, 1.15 mmol) was added, followed by HATU (164 mg, 0.43 mmol) and the mixture stirred for 10 min. (2-{4-[6-Fluoro-2,4-dioxo-l-(tetrahydro- thiopyran-4-yl)-l,4-dihydro-2H-pyrido[2,3-d]pyrimidin-3-yl]-cyclohexylamino}-ethyl)- carbamic acid tert-butyl ester (170 mg, 0.32 mmol) was added and the mixture stirred at room temperature overnight. The mixture was evaporated to dryness and the residue taken up into a mixture of TFA/Dichloromethane (1:1) (10 ml). Allowed to stand at room temperature for 2h. before being evaporated to dryness. The residue was dissolved in water (20 ml) and the solution was made basic by the addition of 0.88 aqueous ammonia solution. The solid that precipitated was collected by filtration then purified by reverse phase HPLC (25-95% acetonitrile in aqueous ammonia) to afford the title compound (81 mg, 45%).1H NMR (300 MHz, DMSO-^5 120 C) delta 8.71 (d, IH), 8.55 (d, IH), 8.31 (s, IH), 8.15 (m, IH), 7.93 (s, IH), 7.58 (d, IH), 7.33 (m, IH), 6.96 (t, IH), 5.25 (m, IH), 4.82 (m, IH), 3.51 (q, 2H), 2.84 (m, 6H), 2.06 (m, 4H), 1.93 (m, 3H), 1.60 (m, 3H), 1.46 (m, 4H). APCI (Multimode) m/z: 566 [M+H]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/84240; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 64951-08-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Step (d) N-{4-[6-fluoro-l-(4-fluorobenzyl)-2,4-dioxo-l,4-dihydropyrido[2,3-d]pyrimidin- 3(2H)-yl]cyclohexyl} imidazo[ 1 ,2-a]pyridine-2-carboxamideTo a mixture of imidazo[l,2-a]pyridine-2-carboxylic acid (91mg, 0.56mmol), HATU (mg, 0.55mmol) and 3-(4-aminocy clohexyl)-6-fluoro- 1 – [4-fluorobenzyl] -pyrido [2,3- d]pyrimidine-2,4(lH,3H)-dione (180mg, 0.46mmol) in Chloroform (5 ml) was added ethyl-di-isopropylamine (0.32ml, 1.87mmol) over a period of 20 seconds. Stirring was continued at ambient temperature for 15 hours. Water was added to the clear solution and the mixture was concentrated under reduced pressure using a rotary evaporator. The obtained solid was filtered, washed with water and dried on the sinter to result in the title compound as an off white solid (120mg, 49%). 1H NMR (300MHz, DMSO-J*): delta 8.75 (IH, d); 8.59 (IH, ddd); 8.40 (IH, s); 8.29 (IH, dd); 7.75 (IH, d); 7.69 (IH, d); 7.34 – 7.43 (2H, m); 7.08 – 7.17 (2H, m); 6.99 (IH, ddd); 5.39 (2H, s); 4.86 (IH, bt); 4.17 (IH, bs); 2.45 – 2.69 (2H, bm); 1.94 – 2.04 (2H, bm); 1.54- 1.80 (4H, m).APCI-MS m/z: 531 [MH+].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/84223; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 64951-08-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below.

Production Example 3 N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide N-[3-(Trifluoromethoxy)benzyl]tetrahydro-2H-pyran-4-amine (242 mg), imidazo[1,2-a]pyridine-2-carboxylic acid (194 mg), EDC.HCl (199 mg), HOBt (138 mg), dimethylformamide (5 mL) and triethylamine (0.33 mL) was stirred overnight at room temperature. The solvents were distilled off under reduced pressure and following extraction with ethyl acetate, the extract was washed with a saturated aqueous solution of sodium hydrogencarbonate and saturated saline, and dried over anhydrous magnesium sulfate. The desiccant was filtered off and, thereafter, the solvents were concentrated. The residue was purified by column chromatography (NH silica gel cartridge; ethyl acetate) to give the titled compound (286 mg). 1H NMR (600 MHz, CHLOROFORM-d) d ppm 1.58-1.97 (m, 4H) 3.35-3.58 (m, 2H) 3.92-4.04 (m, 2H) 4.70-5.75 (m, 3H) 6.75-7.66 (m, 7H) 8.00-8.24 (m, 2H) (ESI pos.) m/z: 420 ([M+H]+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; US2012/10414; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 64951-08-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below.

ER-879054-00: As depicted in Scheme 47 above, ER-824188-00 (20.0 mg, 0.0538 mmol) was dissolved in NMP (0.500 mL). Added Imidazo[l,2-a]pyridine-2- carboxylic acid (49.9 mg, 0.308 mmol). Added N,N,N’,N’-Tetramethyl-O-(7- azabenzotriazol-l-yl)uranium hexafluorophosphate (51.2 mg, 0.134 mmol) in NMP (0.500 mL). The reaction was heated at 1000C for 5 minutes in the microwave. The reaction was not complete so it was stirred at room temperature overnight. The mixture was filtered. Purification by LC/MS followed by evaporation using the genevac provided ER-879054-00 (8.6 mg, 31%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; SPYVEE, Mark; CHEN, Qian; CARLSON, Eric; KUSANO, Kuzutomi; WO2011/11494; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Imidazo[1,2-a]pyridine-2-carboxylic acid, blongs to pyridine-derivatives compound. name: Imidazo[1,2-a]pyridine-2-carboxylic acid

Working Example 47 To a mixture of 3-methoxymethyl-1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (500 mg) obtained in Reference Example 14, imidazo[1,2-a]pyridine-2-carboxylic acid (211 mg), triethylamine (657 mg) and N,N-dimethylformamide (3 ml) is added dropwise under ice-cooling, while stirring, a solution of diethyl cyanophosphonate (277 mg) in N,N-dimethylformamide (1 ml), and the mixture is stirred for one hour. The reaction mixture is poured into ice-water and extracted with ethyl acetate. The organic layer is washed with water, dried and concentrated under reduced pressure. The concentrate is purified by means of a silica gel column chromatography (eluent: ethyl acetate), followed by recrystallization to give 2-[2-methoxymethyl-4-(3,4,5-trimethoxybenzyl)piperazin-1-ylcarbonyl]imidazo[1,2-a]-pyridine as colorless prisms (354 mg), m.p. 129-130C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP368670; (1990); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 64951-08-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Imidazo[l,2-a]pyridine-2-carboxylic acid (500 mg, 3.1 mmol) was dissolved in ethanol (20 ml) and platinium oxide (100 mg) was added, and the mixture hydrogenated at 4 bar overnight. The mixture was filtered, and the filtrate evaporated to dryness to afford the sub-title compound (500 mg, 97%). 1H NMR (400 MHz, DMSO-J6) delta 7.63 (s, IH), 3.96 (t, 2H), 2.70 (t, 2H), 1.85 (m, 4H).

According to the analysis of related databases, 64951-08-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2007/108750; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 64951-08-2, blongs to pyridine-derivatives compound. Recommanded Product: 64951-08-2

Working Example 47 To a mixture of 3-methoxymethyl-1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (500 mg) obtained in Reference Example 14, imidazo[1,2-a]pyridine-2-carboxylic acid (211 mg), triethylamine (657 mg) and N,N-dimethylformamide (3 ml) is added dropwise under ice-cooling, while stirring, a solution of diethyl cyanophosphonate (277 mg) in N,N-dimethylformamide (1 ml), and the mixture is stirred for one hour. The reaction mixture is poured into ice-water and extracted with ethyl acetate. The organic layer is washed with water, dried and concentrated under reduced pressure. The concentrate is purified by means of a silica gel column chromatography (eluent: ethyl acetate), followed by recrystallization to give 2-[2-methoxymethyl-4-(3,4,5-trimethoxybenzyl)piperazin-1-ylcarbonyl]imidazo[1,2-a]-pyridine as colorless prisms (354 mg), m.p. 129-130C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP368670; (1990); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem