Category: 65-22-5

An article A novel diarylethene probe with high selective recognition of CN- and Mg2+ and its application WOS:000573273600005 published article about DUAL-CHANNEL RECOGNITION; MOLECULAR LOGIC GATES; TURN-ON SENSOR; FLUORESCENT SENSOR; AQUEOUS-MEDIA; COLORIMETRIC SENSOR; SCHIFF-BASE; CYANIDE; CHEMOSENSOR; MAGNESIUM in [Yuwen, Zhiyang; Li, Hui; Pu, Shouzhi] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nanchang 330013, Jiangxi, Peoples R China; [Mei, Hongxin] Nanchang Normal Univ, Dept Chem, Nanchang 330013, Jiangxi, Peoples R China in 2020.0, Cited 70.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. Recommanded Product: 65-22-5

A chemical sensor composed of pyridoxal hydrochloride schiff base based on diarylethene (1O) was synthesized. Its photochemical properties and selectivity to ions were further studied. The chemosensor could detect cyanide effectively and is almost undisturbed by other ions. When titrating CN-, the reaction aroused a distinct change in the absorption spectrum with the color change from transparent to yellow, and the fluorescence intensity centered at 562 nm was increased 68 folds. It also exhibited a good fluorescence sensing of Mg(2+ )with high selectivity and sensitivity. Upon addition of Mg2+, its emission intensity enhanced 110 folds, with the color change from dark to bright blue. Its good spectral response could be applied to molecular logic circuit. Moreover, the chemosensor could be made into test paper strips for the qualitative and quantitative detection of CN- and Mg2+.

Recommanded Product: 65-22-5. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Yuwen, ZY; Mei, HX; Li, H; Pu, SZ or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2021.0 POLYHEDRON published article about TRANSITION-METAL-COMPLEXES; EFFECTIVE CORE POTENTIALS; GROWTH-FACTOR RECEPTOR; THIOSEMICARBAZONE DERIVATIVES; BIOLOGICAL-ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; COPPER(II) COMPLEXES; LIGANDS; NICKEL(II); ANTITUMOR in [Poladian, Qumars; Ilhan-Ceylan, Berat; Kurt, Yasemin] Istanbul Univ Cerrahpasa, Engn Fac, Dept Chem, TR-34320 Istanbul, Turkey; [Sahin, Onur] Sinop Univ, Fac Hlth Sci, Dept Occupat Hlth & Safety, TR-57000 Sinop, Turkey; [Karakurt, Tuncay] Kirsehir Ahi Evran Univ, Fac Engn Architecture, Dept Chem & Proc Engn, TR-40100 Kirsehir, Turkey in 2021.0, Cited 69.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. Recommanded Product: 65-22-5

A new unsymmetrical N2O2-tetradentate Schiff-base complex of zinc(II) was synthesized by the template reaction of pyridoxal-S-methylthiosemicarbazone and 2-hydroxy-4-methoxy-benzaldehyde as starting compounds. S-methylthiosemicarbazone (1) and zinc(II) complex [Zn(L)CH3OH] ( 2) were characterized by elemental analysis, FT-IR, UV-visible, H-1, and C-13 NMR spectra. The molecular structure of the complex (2) was determined by single crystal X-ray diffraction technique. The structure consists of a distorted square-pyramidal geometry around the central metal, Zn(II). Quantum chemical calculations were carried out using density functional theory DFT/B3LYP, 6-31G (d), and LanL2DZ basis sets for theoretical characterization of the compounds. The experimental and theoretical data were compared comprehensively. The potential energy distribution (PED) analysis was performed for the assignment of vibration frequencies. In order to support in vitro studies, molecular docking studies have been carried out so that the title compound can be an inhibitor of Epidermal Growth Factor Receptor (1 m17), and the relationship between calculated HOMO energies and docking studies has been examined. In addition, the total antioxidant capacity (as TEAC value) and free radical scavenging activity of the compounds were determined by Cupric Reducing Antioxidant Capacity (CUPRAC) and 1,1-diphenyl-2-picryl hydrazyl (DPPH) methods, respectively. (C) 2021 Elsevier Ltd. All rights reserved.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Poladian, Q; Sahin, O; Karakurt, T; Ilhan-Ceylan, B; Kurt, Y or concate me.. Recommanded Product: 65-22-5

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, molecular formula is C8H10ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

H2L2 was prepared by stirring 2-aminophenol (0.218 g, 2.00 mmol) dissolved in 6 mL of methanol/KOH pH ca. 9.0 and pyridoxal hydrochloride (0.407 g, 2.00 mmol) in 8 mL methanol, at room temperature for 3 h. After cooling the mixture was kept at 4 C overnight and the orange solid was filtered, washed with water, cold methanol and diethyl ether and dried under vacuum. Yield: 85%, 0.390 g. MM (C14H14N2O3) = 258.3 g/mol. Elemental Analysis: Calc. forC14H14N2O3: C, 65.11; H, 5.46; N, 10.85; Found: C, 64.9; H, 5.7; N,10.7. ESI-MS: m/z [Found (Calcd)]: 259.15 (259.3) (100%) [L+H]+;257.11 (257.29) (100%) [L-H]-. UV-Vis in dmso, lambdamax/nm (epsilon/M-1cm-1): 295 (8282), 360 (11601), 463 (421); 1H NMR (dmso-d6, delta/ppm): 2.55 (s, 3H, H17); 4.89 (s, 2H, H18); 6.97 (t, 1H, H2); 7.07 (d, 1H,H6); 7.28 (t, 1H, H1); 7.69 (d, 1H, H3); 7.98 (s, 1H, H12); 9.30 (s, 1H,H9); 5.63 (s, 1H, R-OH) and 10.45 (s, 1H, Ar-OH). 13C NMR (dmso-d6,delta/ppm): 16.15 (C17); 57.83 (C18); 116.82 (C6); 119.64 (C2); 119.73(C3); 121.82 (C11); 129.43 (C12); 130.45 (C1); 131.30 (C4); 136.82(C10); 147.13 (C14); 151.98 (C15); 156.28 (C9) and 157.82 (C5).LogP = 2.21 [24].

With the rapid development of chemical substances, we look forward to future research findings about 65-22-5.

Reference:
Article; Cavaco, Isabel; Correia, Isabel; Costa Pessoa, Joao; Marques, Fernanda; Nunes, Patrique; Inorganica Chimica Acta; vol. 507; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 65-22-5 ,Some common heterocyclic compound, 65-22-5, molecular formula is C8H10ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The synthetic routes for ligands (H3L1-2*Cl) are presented in Scheme 2. Pyridoxal N(4)-substituted thiosemicarbazone hydrochloride has been prepared according to a modification of the procedure described in the literature [25]. Substituted thiosemicarbazide (2 mmol) was dissolved in 10 mL of ethanol with constant stirring, and was added to pyridoxal hydrochloride (2 mmol) dissolved in 10 mL of ethanol. The mixture was stirred at 80 C for 30 min. After the reaction mixture was cooled to room temperature, the yellow solid was isolated by filtration, washed with ethanol and dried in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 65-22-5, 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Manikandan, Rajendran; Vijayan, Paranthaman; Anitha, Panneerselvam; Prakash, Govindan; Viswanathamurthi, Periasamy; Butcher, Ray Jay; Velmurugan, Krishnaswamy; Nandhakumar, Raju; Inorganica Chimica Acta; vol. 421; (2014); p. 80 – 90;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, molecular formula is C8H10ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

To a solution of 0.25 mmol (0.036 g) triethylenetetramine in10 mL methanol, 0.5 mmol (0.1 g) of pyridoxal chloridrate and1.3 mmol (136 mL) triethylamine were added. The solution was heated in an oil-bath at 55 C and stirred by 15 min. Then a solution of 0.25 mmol (0.091 g) of Ni(ClO4)26H2O in 5 mL methanol was dropped to the main solution, which was stirred at 55 C by 1 h. The slow evaporation of the solvent afforded orange crystals after 4days. A similar one-pot synthesis was already reported [13].Yield: 65%. Melting point: 118e119 C. Anal. Calc: C22H34N6O6Ni:C, 49.19; H, 6.33; N,15.65. Found: C, 49.12, H, 6.39; N,15.44%. IR (KBrpellets, cm1): 3526 [m, n(OeH)alcohols]; 3302 [m, n(OeH)alcohol];2921 [w, n(CeH)sp3)]; 1637 [s, n(C]N)]; 1312 [m, n(OeH)alcohol]1263 [m, n(CeO)phenol.]; 1201[s, n(CleO)percholate]; 1012 [s,n(CeO)alcohols].

With the rapid development of chemical substances, we look forward to future research findings about 65-22-5.

Reference:
Article; Back, Davi Fernando; De Oliveira, Gelson Manzoni; Fontana, Liniquer Andre; Ramao, Brenda Fiorin; Roman, Daiane; Iglesias, Bernardo Almeida; Journal of Molecular Structure; vol. 1100; (2015); p. 264 – 271;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C8H10ClNO3

General procedure: In a round bottom flask, pyridoxal hydrochloride (0.201g; 1.0mmol) was added to methanol (15mL) and the resulting suspension was subjected to magnetic stirring at room temperature until complete dissolution of the pyridoxal molecule. Then, the corresponding aniline (0.120g of 2-fluoroaniline; 0.130g of 2-chloroaniline, 0.170g of 2-bromoaniline or 0.220g of 2-iodoaniline; 1.0mmol for each) dissolved in methanol (5 mL) was added. The resulting mixture was kept under magnetic stirring at reflux temperature for 2.0h. After this period, the flask contents were cooled to room temperature and the solvent evaporated. The resulting solid was washed with small portions of ice water and diethyl ether and dried in a desiccator with CaCl2. For the synthesis of the ligand containing aniline, the same conditions were used, but without potassium hydroxide (0.093g of aniline was added to 15mL of methanol and 1mmol of pyridoxal hydrochloride; 0.201g). Properties – orange crystals, yield 85%. Melting point: 207C. Anal.Calc. for [C14H13BrN2O2] C, 47.02; H, 3.95; N, 7.83. Found: C, 46.93; H, 3.90; N, 7.79%. IR (KBr pellets, cm-1): 3209 [w, nu(O-H)]; 1627 [m, nu(C=N)]; 1387 [m, nu(C-N)], 1257 [s, nu(C-O)phenol], 1033 [s, nu(C-O)alcohols], 694 [m, nu(C-Br)alcohols] and 620 [s, nu(O-H)alcohols] (w=weak; m=medium; s=strong). 1H NMR (ppm, DMSO-d6): delta 2.46 (s, 3H, CH3); 4.80 (s, 2H, CH2); 7.32-7.81 (m, 4H, Ar); 8.03 (s, 1H, Py) and 9.21 (s, 1H, CHimine)

With the rapid development of chemical substances, we look forward to future research findings about 65-22-5.

Reference:
Article; Pereira, Mateus Brum; Fontana, Liniquer Andre; Siqueira, Josieli Demetrio; Auras, Bruna L.; da Silva, Marcos P.; Neves, Ademir; Gabriel, Philipe; Terenzi, Hernan; Iglesias, Bernardo Almeida; Back, Davi Fernando; Inorganica Chimica Acta; vol. 469; (2018); p. 561 – 575;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 65-22-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 65-22-5 as follows.

General procedure: The ligands L3, L4, L5 and L6 were synthesized using pyridoxal hydrochloride (0.180g, 8mmol) solubilized in methanol (15mL). Then 4-hydroxybenzoic hydrazide (L3), 4-methoxybenzoic hydrazide (L4), 4-aminobenzoic hydrazide (L5), and 4-nitrobenzoic hydrazide (L6) were added (0.134g, 0.146g, 0.133g, 0.160g, 8mmol each, respectively). The reaction solution remained at 50C and constant stirring, with reaction time of 2h (L3-L4) and 3h (L5-L6). After this period, the reaction mixture was cooled to room temperature and the methanol was then evaporated under reduced pressure, whereby a yellow solid was obtained (Scheme 2 ). Thin-layer chromatography plates monitored the reactions (Hex/Ac 80-20). The synthetic route used to obtain the L4 ligand is similar to that proposed by K. Ramdasand and co-workers [29].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65-22-5, its application will become more common.

Reference:
Article; Arantes, Leticia Priscilla; Back, Davi Fernando; Chaves, Otavio Augusto; Iglesias, Bernardo Almeida; Neves, Ademir; Piquini, Paulo Cesar; Siqueira, Josieli Demetrio; Soares, Felix Antunes; de Pellegrin, Sidnei Flores; dos Santos, Sailer Santos; Journal of Inorganic Biochemistry; vol. 204; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 65-22-5, Adding some certain compound to certain chemical reactions, such as: 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride,molecular formula is C8H10ClNO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 65-22-5.

A solution of pyridoxal hydrochloride (10 mmol) in methanol was added to a methanolic solution of NEt3 (10 mmol in 10 ml). The mixture was stirred for 10 min. Then, a methanolic solution of 4-methyl-orthophenylenediamine (5 mmol in 5 ml) was slowly added to the reaction mixture. The obtained mixture was stirred for 5 h at room temperature. Then, the obtained orange solid was filtered off, washed with cold methanol, and dried in air to give the H2L Schiff base (Yield: 92%, Dec.; 232.6 C, the molecular ion peaks, m/z (M+) = 420).

According to the analysis of related databases, 65-22-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yavari; Beyramabadi; Morsali; Bozorgmehr; Journal of Structural Chemistry; vol. 59; 5; (2018); p. 1102 – 1113; Zh. Strukt. Khim.; vol. 59; 5; (2017); p. 1144 – 1154,11;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 65-22-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

2.2.1 PLSC·2H2O Semicarbazide hydrogenchloride (1.07 g, 10 mmol) was dissolved in warm H2O (10 mL), to which a warm solution of pyridoxal hydrogenchloride (2.00 g, 10 mmol) in H2O (10 mL) was added. To this solution Na2CO3·10H2O (3.00 g, 15 mmol) dissolved in H2O (10 mL) was added in portions, and the mixture was mildly heated for a couple of minutes. The obtained solution was left at room temperature for about 20 h, after which the single crystals were filtered and washed with H2O. Yield: 2.30 g (88%). Anal. Calc. for C9H16N4O5: C, 41.54; H, 6.20; N, 21.53. Found: C, 41.43; H, 6.16; N, 21.50%. Selected IR bands [ /cm-1]: 3466, 3381, nu(OH), nu(NH2); 3202, nu(NH); 2850, nu(NH+); 1697, 1678, nu(C=O); 1583, nu(CN); 1280, nu(COphenolic). UV-Vis (DMF) [lambdamax/nm (log epsilon/M-1 cm-1)]: 289 (4.12), 298sh (4.08), 327bp (3.75) (sh-shoulder, bp-broad peak).

According to the analysis of related databases, 65-22-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Vojinovi?-Je?i?, Ljiljana S.; Jovanovi?, Ljiljana S.; Leovac, Vukadin M.; Radanovi?, Mirjana M.; Rodi?, Marko V.; Barta Hollo, Berta; Meszasaros Szecsenyi, Katalin; Ivkovi?, Sonja A.; Polyhedron; vol. 101; (2015); p. 196 – 205;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, the common compound, a new synthetic route is introduced below. Computed Properties of C8H10ClNO3

General procedure: To a solution of pyridoxal hydrochloride 5 (2.0 mmol, 0.40 g) in water (1 mL) was added the corresponding chromone 6 (2.0 mmol) in methanol (2-10 mL) and NaOH (5.2 mmol, 0.21 g). The reaction mixture was stirred at 50 C for 4-6 h, cooled to ?20 C and allowed to stand at room temperature for 18-36 h (for 6d: ?20 C, 4 h). The resulting mixture was diluted with water (10 mL) and neutralized with HCl to pH 7. The solid that formed was filtered, washed with water, dried, and recrystallized from methanol to give product 7 as an orange powder.

The synthetic route of 65-22-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sosnovskikh, Vyacheslav Ya; Korotaev, Vladislav Yu.; Barkov, Alexey Yu.; Sokovnina, Anna A.; Kodess, Mikhail I.; Journal of Fluorine Chemistry; vol. 141; (2012); p. 58 – 63;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem