Category: 65-22-5

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 65-22-5, Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, SMILES is O=CC1=C(CO)C=NC(C)=C1O.[H]Cl, belongs to pyridine-derivatives compound. In a document, author is Koh, Eun Hye, introduce the new discover, Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride.

A cyclodextrin-decorated plasmonic gold nanosatellite substrate for selective detection of bipyridylium pesticides

A cyclodextrin-decorated gold nanosatellite (AuNSL) substrate was developed as a surface-enhanced Raman scattering sensor for the selective sensing of bipyridylium pesticides such as paraquat (PQ), diquat (DQ), and difenzoquat (DIF). The AuNSL structure was fabricated via vacuum deposition of gold nanoparticles (AuNPs) on a gold nanopillar substrate, and a large density of hot-spots was formed for Raman signal enhancement. Thiolated beta-cyclodextrin (SH-CD) was surface-modified on the AuNSL as a chemical receptor. The detection limit of PQ, DQ, and DIF on the SH-CD-coated AuNSL (CD-AuNSL) was 0.05 ppm for each, and showed linear correlation in a concentration range of 10 ppm-0.05 ppm. Then, selective bipyridylium pesticide detection was performed by comparing the Raman intensity of each pesticide with and without the washing step. After the washing step, 90% of the PQ, DQ, and DIF Raman signals were maintained on the CD-AuNSL substrate with a uniform selectivity in a mapping area of 200 mu m x 200 mu m. Furthermore, selective pesticide detection was performed using a ground-apple solution without pretreatment. Raman signals were clearly observed after the washing step and they showed a limit of detection down to a concentration of 0.05 ppm for each pesticide. Principal component analysis (PCA) of the binary and ternary mixtures of PQ, DQ, and DIF showed that each component could be easily identified via the typical Raman fingerprint analysis. The developed CD-AuNSL is expected to be applied for various chemical sensors, especially for pyridine-containing toxic substances in the environment and metabolite biomarkers in biofluids.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 65-22-5 is helpful to your research. Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Related Products of 65-22-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. A new synthetic method of this compound is introduced below.

In a round bottom flask containing 7 mL methanol and 3 mL of DMF was added the diamine N2S2-4C¡¤2HCl (0.1 mmol; 0.038 g), pyridoxal hydrochloride (0.2 mmol; 0.041 g) and 60 muL of triethylamine. The resulting suspension was heated at 60 C with magnetic stirring and then was added nickel perchlorate (0.1 mmol; 0.036 g). The resulting mixture was stirred at 60 C for 45 min. After this period, the flask contents the solution was cooled to room temperature and filtered. Red crystals were collected after 4 days by slow evaporation of the solvent. Yield (crystals): 84%. Melting point: up 250 C. IR (KBr pellets cm-1): nu(O-Halcohol) 3362 s, nu(Caliphatic-H) 2929 w, nu(C = N) 1602 s, nu(C = O DMF) 1654 s, nu(C-S) 761 m,. Anal. Calc.: C, 54.67; H, 5.24; N, 9.11. Found: C, 54.60; H, 5.49; N, 8.98.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,65-22-5, 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, and friends who are interested can also refer to it.

Reference:
Article; Fontana, Liniquer Andre; Stueker, Monica; Oliveira, Gelson Manzoni; Iglesias, Bernardo Almeida; Back, Davi Fernando; Inorganic Chemistry Communications; vol. 62; (2015); p. 55 – 59;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65-22-5, 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 65-22-5, blongs to pyridine-derivatives compound. Computed Properties of C8H10ClNO3

General procedure: The desired compounds 1a-g and 2a-f were prepared by reaction between pyridoxal hydrochloride (0.15 g, 0.74mmol) and the appropriate aromatic or heteroaromatic hydrazine or N-acylhydrazine (1.1 eq., 0.81mmol) in ethanol (10.0 mL). The reaction mixture was stirred for 1-48 hours at room temperature. After that, product was purified by wash-ing with cold ethanol (3.0 mL) and cold diethyl ether (3.0 mL), leading to the pure derivatives 1a-g and 2a-f as solid in 42-86% yields.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65-22-5, its application will become more common.

Reference:
Article; Nogueira, Thais Cristina Mendonca; Cruz, Lucas Dos Santos; Lourenco, Maria Cristina; de Souza, Marcus Vinicius Nora; Letters in drug design and discovery; vol. 16; 7; (2019); p. 792 – 798;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem