Category: 6515-09-9

Adding a certain compound to certain chemical reactions, such as: 6515-09-9, 2,3,6-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6515-09-9, blongs to pyridine-derivatives compound. Computed Properties of C5H2Cl3N

A solution of n-butyllithium in hexanes (2.5M, 30 mmol, 12 mL) was added drop-wise to a solution of (1321) diisopropylamine (30 mmol, 4.3 mL) in dry THF (100 mL) at -78 C. After 1 hour, a solution of 2,3,6- trichloropyridine (27.4 mmol, 5 g) in dry THF (25 mL) was added over 15 minutes. After a further 1 hour, a (1322) solution of methyl iodide (30.4 mmol, 1.9 mL) in dry THF (10 mL) was added drop-wise over 5 minutes. The orange- brown solution was stirred at -78 C for 15 minutes, then allowed to warm to room temperature and stirred at room temperature for 18 hours. The reaction was carefully quenched by the addition of saturated aqueous ammonium chloride solution and the mixture was extracted with ethyl acetate. The organic extract was washed with brine, dried (MgS04) and concentrated under reduced pressure. Partial purification of the crude product was achieved by column chromatography (silica gel, gradient of ethyl acetate in isohexane) to give the intermediate 2 , 3 , 6-trichloro-4-methylpyridine as an oily colourless solid (2.4 g) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6515-09-9, its application will become more common.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; SAITO, Tetsuji; HIGASHINO, Masato; KAWAHARADA, Soichi; LEWIS, Arwel; CHAMBERS, Mark Stuart; RAE, Alastair; HIRST, Kim Louise; HARTLEY, Charles David; WO2015/115673; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6515-09-9, 2,3,6-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6515-09-9, blongs to pyridine-derivatives compound. Computed Properties of C5H2Cl3N

A solution of n-butyllithium in hexanes (2.5M, 30 mmol, 12 mL) was added drop-wise to a solution of (1321) diisopropylamine (30 mmol, 4.3 mL) in dry THF (100 mL) at -78 C. After 1 hour, a solution of 2,3,6- trichloropyridine (27.4 mmol, 5 g) in dry THF (25 mL) was added over 15 minutes. After a further 1 hour, a (1322) solution of methyl iodide (30.4 mmol, 1.9 mL) in dry THF (10 mL) was added drop-wise over 5 minutes. The orange- brown solution was stirred at -78 C for 15 minutes, then allowed to warm to room temperature and stirred at room temperature for 18 hours. The reaction was carefully quenched by the addition of saturated aqueous ammonium chloride solution and the mixture was extracted with ethyl acetate. The organic extract was washed with brine, dried (MgS04) and concentrated under reduced pressure. Partial purification of the crude product was achieved by column chromatography (silica gel, gradient of ethyl acetate in isohexane) to give the intermediate 2 , 3 , 6-trichloro-4-methylpyridine as an oily colourless solid (2.4 g) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6515-09-9, its application will become more common.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; SAITO, Tetsuji; HIGASHINO, Masato; KAWAHARADA, Soichi; LEWIS, Arwel; CHAMBERS, Mark Stuart; RAE, Alastair; HIRST, Kim Louise; HARTLEY, Charles David; WO2015/115673; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 6515-09-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6515-09-9, name is 2,3,6-Trichloropyridine, molecular formula is C5H2Cl3N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1000mL reaction flask,Added 2,3,6-trichloropyridine 200g,N,N-dimethylethanolamine 300g stirring at room temperature,Add 80% hydrazine hydrate solution 100gAfter the addition,Rising temperature reflux 110 ~ 115 C,After 10 hours of reaction,Sampling HPLC monitoring control raw material (trichloropyridine) Cool to 0 ~ 10 C,Precipitation of solids,filter;Solids are washed with a small amount of water,dry;The product 2-hydrazino-3,6-dichloropyridine ~190g,Yield ~ 97.1% (theory: 195.6g);

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6515-09-9, 2,3,6-Trichloropyridine.

Reference:
Patent; Shanghai Yaben Chemical Co., Ltd.; Lin Zhigang; Jiang Yueheng; Cai Tong; (5 pag.)CN107778225; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6515-09-9, Adding some certain compound to certain chemical reactions, such as: 6515-09-9, name is 2,3,6-Trichloropyridine,molecular formula is C5H2Cl3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6515-09-9.

2,5,6-Trichloro-3-nitropyridine (Example 8) 3.6 g. (0.02 mol) of 2,5,6-trichloropyridine are dissolved in a mixture of 20 ml of 100% strength fuming nitric acid and 16 ml of concentrated sulphuric acid and are then heated at 100C in an oil bath for 12 hours. After cooling to approx. 20C, the reaction mixture is poured onto ice. The crude product is produced in the form of slightly yellowish crystals, which are filtered off with suction, washed with water and dried at 30C in vacuo over KOH. 3 g (66.7% of theory) of 2,5,6-trichloro-3-nitropyridine are obtained in the form of crystals which, after sublimation at 30 – 40C/12 mm Hg. melt at 68 – 70C. Analysis for C5 HCl3 N2 O2 (molecular weight 227.4): calculated C 26.41% H 0.44% Cl 46.77% N 12.32% found C 26.2% H 0.5% Cl 47.0% N 12.2%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6515-09-9, 2,3,6-Trichloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ciba-Geigy Corporation; US3974166; (1976); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6515-09-9, Adding some certain compound to certain chemical reactions, such as: 6515-09-9, name is 2,3,6-Trichloropyridine,molecular formula is C5H2Cl3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6515-09-9.

2,5,6-Trichloro-3-nitropyridine (Example 8) 3.6 g. (0.02 mol) of 2,5,6-trichloropyridine are dissolved in a mixture of 20 ml of 100% strength fuming nitric acid and 16 ml of concentrated sulphuric acid and are then heated at 100C in an oil bath for 12 hours. After cooling to approx. 20C, the reaction mixture is poured onto ice. The crude product is produced in the form of slightly yellowish crystals, which are filtered off with suction, washed with water and dried at 30C in vacuo over KOH. 3 g (66.7% of theory) of 2,5,6-trichloro-3-nitropyridine are obtained in the form of crystals which, after sublimation at 30 – 40C/12 mm Hg. melt at 68 – 70C. Analysis for C5 HCl3 N2 O2 (molecular weight 227.4): calculated C 26.41% H 0.44% Cl 46.77% N 12.32% found C 26.2% H 0.5% Cl 47.0% N 12.2%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6515-09-9, 2,3,6-Trichloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ciba-Geigy Corporation; US3974166; (1976); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6515-09-9, Adding some certain compound to certain chemical reactions, such as: 6515-09-9, name is 2,3,6-Trichloropyridine,molecular formula is C5H2Cl3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6515-09-9.

EXAMPLE 2 Preparation of 3,6-dichloro-2-(dichloromethyl)pyridine (Cpd. 2 of table) STR4 2,3,6-Trichloropyridine (1.0 g, 0.0055 mole) was combined with 4 g N-methylpyrrolidone, 4 g (0.033 mole) of chloroform, and 1.0 g of 50 percent aqueous sodium hydroxide (0.013 mole). The resulting mixture was stirred and warmed mildly for about 1 hour at which time the product was found to be present in the reaction mixture by gas chromatography and mass spectrometry using an authentic sample of the product as a standard. After standing overnight at ambient temperature the title compound represented about 1.7 percent of the pyridines in the mixture.

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Dow Chemical Company; US4739070; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

In a 2000-liter reactor, 546 kg of methanol, 182 kg of 2,3,6-trichloropyridine, 0.546 kg of 5% palladium-carbon (55% water), 28 kg of magnesium hydroxide and 46 kg of formic acid were added, and the mixture was stirred and heated up. At 40 degrees Celsius, nitrogen was replaced three times, and then hydrogen was introduced to maintain the pressure at 0.1-0.4 MPa. After 4 hours of reaction, the reaction was stopped to obtain a reaction solution. The reaction solution was filtered again, palladium carbon catalyst was recovered, and the first filtrate was obtained. The first filtrate was rectified and methanol was rectified for the next batch of cycle reactions. After the distillation of methanol is completed, water is added to the system to obtain a mixed and melted organic liquid of 2,3,6-trichloropyridine and 2,3-dichloropyridine.The organic liquid was slowly added dropwise to 182 kg of 25% hydrochloric acid, stirred at 5-10 degrees Celsius for 4 hours, and then pressure-filtered to recover 75 kg of unreacted 2,3,6-trichloropyridine and obtain the second filtrate. . At 10-15 degrees Celsius, 500 kg of water was added to the second filtrate to precipitate 2,3-dichloropyridine, which was filtered to give a product of 75 kg. In this embodiment, 5% palladium-carbon (water containing 55%) means that in the palladium carbon catalyst, the mass percentage of palladium is 5%, and the water content is 55%.Based on the improvement of the reaction process, the amount of palladium carbon catalyst used in the present invention is greatly reduced. The product was found to have a content of 2,3-dichloropyridine of 99% and a yield of 87%.

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Lier Chemical Co., Ltd.; Li Yuedong; Ren Jie; Li Jianwei; Liu Qiang; He Hongyun; (6 pag.)CN107721913; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6515-09-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6515-09-9, name is 2,3,6-Trichloropyridine. A new synthetic method of this compound is introduced below.

General procedure: TCP A (333 mg), complex (1.71 mol%) and solvent (3 mL) are added to each reactor, followed byNEt3 (446 microL). The reactor is purged with nitrogen (3 times) and hydrogen (3 times) thenhydrogenated at 5 bar and various reactor temperatures for 60 mins in a Biotage Endeavor. 40 pL aliquot of each reaction mixture is added to 1 mL MeCN and analysed by normal HPLC method. HPLC areas are converted to concentration (pmol/mL) from the gradients equations in the multipoint external standard.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6515-09-9, 2,3,6-Trichloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; MORTIMER, Danny Lee; (19 pag.)WO2017/85476; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6515-09-9, Adding some certain compound to certain chemical reactions, such as: 6515-09-9, name is 2,3,6-Trichloropyridine,molecular formula is C5H2Cl3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6515-09-9.

18.4 g (0.1 mol) 2,3,6-trichloropyridine was dissolved in 70 g glacial acetic acid and 0.54 g molybdenum trioxide was added,The temperature was raised to 80 C, 13.6 g (0.12 mol) of hydrogen peroxide (30%) was slowly dropped,Full response, liquid chromatography control, the reaction is over, the catalyst was filtered, the filtrate was concentrated to recover acetic acid, 2,3,6-trichloropyridine nitrogen oxide 18.2g, yield 90%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6515-09-9, 2,3,6-Trichloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Hong Sun Biochemical Co., Ltd.; Jiang Jianhua; Yue Ruikuan; Jiang Tao; Chen Honglong; Luo Chaoran; (6 pag.)CN106243027; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

In a 2000-liter reactor, 546 kg of methanol, 182 kg of 2,3,6-trichloropyridine, 0.546 kg of 5% palladium-carbon (55% water), 28 kg of magnesium hydroxide and 46 kg of formic acid were added, and the mixture was stirred and heated up. At 40 degrees Celsius, nitrogen was replaced three times, and then hydrogen was introduced to maintain the pressure at 0.1-0.4 MPa. After 4 hours of reaction, the reaction was stopped to obtain a reaction solution. The reaction solution was filtered again, palladium carbon catalyst was recovered, and the first filtrate was obtained. The first filtrate was rectified and methanol was rectified for the next batch of cycle reactions. After the distillation of methanol is completed, water is added to the system to obtain a mixed and melted organic liquid of 2,3,6-trichloropyridine and 2,3-dichloropyridine.The organic liquid was slowly added dropwise to 182 kg of 25% hydrochloric acid, stirred at 5-10 degrees Celsius for 4 hours, and then pressure-filtered to recover 75 kg of unreacted 2,3,6-trichloropyridine and obtain the second filtrate. . At 10-15 degrees Celsius, 500 kg of water was added to the second filtrate to precipitate 2,3-dichloropyridine, which was filtered to give a product of 75 kg. In this embodiment, 5% palladium-carbon (water containing 55%) means that in the palladium carbon catalyst, the mass percentage of palladium is 5%, and the water content is 55%.Based on the improvement of the reaction process, the amount of palladium carbon catalyst used in the present invention is greatly reduced. The product was found to have a content of 2,3-dichloropyridine of 99% and a yield of 87%.

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Lier Chemical Co., Ltd.; Li Yuedong; Ren Jie; Li Jianwei; Liu Qiang; He Hongyun; (6 pag.)CN107721913; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem