Category: 6515-09-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2Cl3N

In a 1000 ml stainless steel autoclave, 50 g of 2,3,6-trichloropyridine was added.300g of methanol, 35g of triethylamine, and then added 0.05g of 10% palladium carbon.First replace the air in the kettle three times with nitrogen, and then replace it three times with hydrogen.Pressurize to 4.0Mpa and control the temperature at 45~50C.The reaction speed was set to 300 rpm/min, and hydrogen was continuously added during the reaction.The reaction pressure was maintained at 3.0 to 4.0 MPa, and the reaction was stopped after 4 hours of reaction.Cooling, sampling for liquid phase quantitative detection and analysis,The conversion rate of raw material 2,3,6-trichloropyridine is 96.5%.The selectivity to 2,3-dichloropyridine was 86.7%. After filtering the reaction solution,After rectifying and removing the reaction solvent, after adding a moisture layer,The organic phase was subjected to rectification to obtain 33.1 g of a white 2,3-dichloropyridine product.The product purity is 99.5%.

With the rapid development of chemical substances, we look forward to future research findings about 6515-09-9.

Reference:
Patent; Chongqing Zhong Bang Technology Co., Ltd.; Wang Ping; Lai Ming; Mu Xinbin; Jiang Cheng; Li Xueping; (5 pag.)CN109280026; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

557.8g 2,3,6-trichloropyridine, which is obtainedby the chlorination, 123.5g triethylamine, 8.4g palladium-carbon and 1673g toluene are added to a reactorfor one time, then heated to 60?80C, and hydrogen gasis introduced to proceed hydrogenating. When pH valueof the reaction solution reaches 4?8, stopping introduci After the aforementioned reaction solution wascooled to room temperature, 420g water is added for dissolvingtriethylamine hydrochloride. Then the reactionsolution is filtered, and the cake which is palladium carbonwashed by 30g water and 30g toluene can be recycled.The filtrate is allowed to stand stratification, andthen the toluene layer is extracted by 200g hydrochloricacid at least three times after the water was separated.The extracted solution can be recycled for the next batchwith replenishing 2,3,6-trichloropyridine and toluene. Thehydrochloride layers are combined and diluted by 1630gwater after extraction, and then solid is crystallized. Thesolid is washed by 100g water (the waste water can berecycled for extraction) after filtration, then wet 2,3-dichloropyridine is given. Dry product of 2,3-dichloropyridineis given by drying the wet product. Finally, 387.7gproduct is totally gained when the waste water is recycled,and the yield is 85.7%, the purity is greater than orequal to 99.5%.

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Lianhe Chemical Technology Co., Ltd.; Jiangsu Lianhe Chemical Technology Co., Ltd; WANG, Ping; FAN, Xiaobin; ZHANG, Juntao; YE, Fangsheng; EP2687510; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

2, 3, 6-Trichloropyridine (62 mmol, 11.27 g) was dissolved in a mixture of fuming nitric acid (62 mL) and concentrated sulphuric acid (50 mL) and heated at 100C for 12 hours. The mixture was cooled, carefully poured into ice/water then extracted with dichloromethane. The organic extract was dried (MgS04) then concentrated under reduced pressure to give the title compound as pale green oil which solidified on standing (9.65 g, 68%).

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; SAITO, Tetsuji; HIGASHINO, Masato; KAWAHARADA, Soichi; LEWIS, Arwel; CHAMBERS, Mark Stuart; RAE, Alastair; HIRST, Kim Louise; HARTLEY, Charles David; WO2015/115673; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6515-09-9, 2,3,6-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2,3,6-Trichloropyridine, blongs to pyridine-derivatives compound. Quality Control of 2,3,6-Trichloropyridine

Example 11 Compound No. 37 in Table 1 [0087] 2-chloro-5-ethylaminomethylthiazole, 18.6 g of 2,3,6-trichloropyridine, 30.0 g of potassium carbonate and 200 mL of N,N-dimethylformamide (DMF) were added in a 500 mL single neck flask equipped with a magnetic stirrer. After stirred at reflux temperature for 4 to 6 hours, the reaction mixture was extracted with ethyl acetate, the organic layer was separated while the aqueous layer was extracted with ethyl acetate twice. The organic phases were combined, and dried over anhydrous sodium sulfate after washed with an iced aqueous sodium chloride solution twice, then remove the solvent under reduced pressure to obtain 25.0 g of crude product which was purified by a silica gel column chromatography using a petroleum ether/ ethyl acetate (20/1) as an eluent to obtain 13.0 g of 6-chloro-N-((2-chlorothiazole-5-yl)methyl)-N-ethyl-3-chloropyridin-2-amine, having the content 91.0%, as a yellow viscous liquid, and rod-like crystals were generated after standing, m.p.: 95.8-96.8 ? GC-MS (M+) (EI, 70 eV, m/z) calc: 321; found: 321; 1H NMR (CDCl3/TMS, 300 MHz) delta (ppm) 1.179 (t, J=7.2 Hz, 3H, CH3), 3.413 (q, J=7.2 Hz, 2H, CH2), 4.726 (s, 2H, CH2), 6.378 (d, J=8.7 Hz, 1H, Py H), 7.447 (d, J=8.7 Hz, 1H, Py H), 7.497 (s, 1H, Thiazole-H).

The synthetic route of 6515-09-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Liu, Aiping; Wang, Xiaoguang; He, Lian; Ou, Xiaoming; Liu, Minhua; Chen, Ming; Liu, Xingping; Tang, Ming; Ren, Yeguo; Chen, Haobin; US2015/51402; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2Cl3N

In a 1000 ml stainless steel autoclave, 50 g of 2,3,6-trichloropyridine was added.300g of methanol, 35g of triethylamine, and then added 0.05g of 10% palladium carbon.First replace the air in the kettle three times with nitrogen, and then replace it three times with hydrogen.Pressurize to 4.0Mpa and control the temperature at 45~50C.The reaction speed was set to 300 rpm/min, and hydrogen was continuously added during the reaction.The reaction pressure was maintained at 3.0 to 4.0 MPa, and the reaction was stopped after 4 hours of reaction.Cooling, sampling for liquid phase quantitative detection and analysis,The conversion rate of raw material 2,3,6-trichloropyridine is 96.5%.The selectivity to 2,3-dichloropyridine was 86.7%. After filtering the reaction solution,After rectifying and removing the reaction solvent, after adding a moisture layer,The organic phase was subjected to rectification to obtain 33.1 g of a white 2,3-dichloropyridine product.The product purity is 99.5%.

With the rapid development of chemical substances, we look forward to future research findings about 6515-09-9.

Reference:
Patent; Chongqing Zhong Bang Technology Co., Ltd.; Wang Ping; Lai Ming; Mu Xinbin; Jiang Cheng; Li Xueping; (5 pag.)CN109280026; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To fuming HNO3 (136 rn) were added H2S04 (111 rn) and 23,6-trichoropyridine (24.2g, 133 mmo) at 0C. The reaction mixture was sHowed to warm to RT, then stirred at100C overnight. After cooing to 0C, the mixture was poured onto ice-water. Theunsoube materia was coHected by fitration to afford 2,3,6-trichoro-5-nitropyridine. Rt =1.07 mm (UPLC Method B2), 1H NMR (400 MHz, DMSO-d6) 6 ppm: 9.06 (s, IH).

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; PISSOT SOLDERMANN, Carole; QUANCARD, Jean; SCHLAPBACH, Achim; SIMIC, Oliver; TINTELNOT-BLOMLEY, Marina; ZOLLER, Thomas; (161 pag.)WO2015/181747; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H2Cl3N

A mixture of 2,3,6-trichloropyridine (18.2 g, 0.1 mol)Pd / C (10%) (2.73 g),1-isopropyl-4-methylcyclohexene (69 g, 0.5 mol) was added to methanol (182 g)Slowly heated to 60 C for 4 hours;After the reaction,The methanol was distilled off by distillation and vacuum distillation,Add water (100 g),The mixture of 2,3-dichloropyridine and water was distilled off by steam distillation at atmospheric pressure,Cooled by filtration to obtain 2,3-dichloropyridine 14g,Purity (HPLC) ?98%Yield 95%.

With the rapid development of chemical substances, we look forward to future research findings about 6515-09-9.

Reference:
Patent; Jiangsu Zhongbang Pharmaceutical Co., Ltd.; Qian, Yong; Xu, Qiang; Gao, Qian; Zhao, Huayang; Zhang, Xiaoqing; (5 pag.)CN106518754; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To fuming HNO3 (136 rn) were added H2S04 (111 rn) and 23,6-trichoropyridine (24.2g, 133 mmo) at 0C. The reaction mixture was sHowed to warm to RT, then stirred at100C overnight. After cooing to 0C, the mixture was poured onto ice-water. Theunsoube materia was coHected by fitration to afford 2,3,6-trichoro-5-nitropyridine. Rt =1.07 mm (UPLC Method B2), 1H NMR (400 MHz, DMSO-d6) 6 ppm: 9.06 (s, IH).

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; PISSOT SOLDERMANN, Carole; QUANCARD, Jean; SCHLAPBACH, Achim; SIMIC, Oliver; TINTELNOT-BLOMLEY, Marina; ZOLLER, Thomas; (161 pag.)WO2015/181747; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H2Cl3N

A mixture of 2,3,6-trichloropyridine (18.2 g, 0.1 mol)Pd / C (10%) (2.73 g),1-isopropyl-4-methylcyclohexene (69 g, 0.5 mol) was added to methanol (182 g)Slowly heated to 60 C for 4 hours;After the reaction,The methanol was distilled off by distillation and vacuum distillation,Add water (100 g),The mixture of 2,3-dichloropyridine and water was distilled off by steam distillation at atmospheric pressure,Cooled by filtration to obtain 2,3-dichloropyridine 14g,Purity (HPLC) ?98%Yield 95%.

With the rapid development of chemical substances, we look forward to future research findings about 6515-09-9.

Reference:
Patent; Jiangsu Zhongbang Pharmaceutical Co., Ltd.; Qian, Yong; Xu, Qiang; Gao, Qian; Zhao, Huayang; Zhang, Xiaoqing; (5 pag.)CN106518754; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To fuming HNO3 (136 rn) were added H2S04 (111 rn) and 23,6-trichoropyridine (24.2g, 133 mmo) at 0C. The reaction mixture was sHowed to warm to RT, then stirred at100C overnight. After cooing to 0C, the mixture was poured onto ice-water. Theunsoube materia was coHected by fitration to afford 2,3,6-trichoro-5-nitropyridine. Rt =1.07 mm (UPLC Method B2), 1H NMR (400 MHz, DMSO-d6) 6 ppm: 9.06 (s, IH).

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; PISSOT SOLDERMANN, Carole; QUANCARD, Jean; SCHLAPBACH, Achim; SIMIC, Oliver; TINTELNOT-BLOMLEY, Marina; ZOLLER, Thomas; (161 pag.)WO2015/181747; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem