Category: 6515-38-4

Application of 6515-38-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6515-38-4, name is 3,5,6-Trichloropyridin-2(1H)-one. A new synthetic method of this compound is introduced below.

General procedure: 2-Chloro-4-(trifluoromethyl)phenol (0.43 g, 2.19 mmol) was dissolved in 15 mL of butanone, and anhydrous potassium carbonate (0.60 g, 4.35 mmol) was added to the solution. The solution was stirred for 0.5 h, and methyl (E)-methyl 2-(2-(bromomethyl)phenyl)-2-(methoxyimino)acetate (0.63 g, 2.20 mmol) was then added. The reaction mixture was heated to 80 C and monitored by TLC. After five hours, the mixture was cooled, diluted with 50 mL water and extracted with ethyl acetate (3 × 100 mL). The combined extracts were washed with brine, dried (anhydrous magnesium sulfate), and filtered. The filtrate was evaporated and the crude product was purified via silica gel column chromatography, using a 1:2 (v/v) mixture of ethyl acetate and petroleum ether (boiling point range: 60-90 C) as the eluting solution to obtain compound 2b as a white solid: 0.67 g (72.9%), mp 115-116 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6515-38-4, its application will become more common.

Reference:
Article; Li, Lin; Li, Miao; Chi, Huiwei; Yang, Jichun; Li, Zhinian; Liu, Changling; Journal of Fluorine Chemistry; vol. 185; (2016); p. 173 – 180;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6515-38-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-38-4, name is 3,5,6-Trichloropyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 4 PREPARATION OF O-(3,5,6-TRICHLORO-2-PYRIDYL) ETHYLPHOSPHONOCHLORIDOTHIONATE 3,5,6-Trichloro-2-hydroxypyridine (9.15 grams; 0.05 mole) and 100 ml of benzene were charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer and the mixture cooled to about 10 C. Triethylamine (5.05 grams; 0.05 mole) was added. The resulting mixture was cooled to 5 C. and ethylphosphonothionic dichloride (8.19 grams; 0.05 mole) dissolved in 10 ml of benzene was added dropwise, with stirring, at this temperature. Stirring was continued for 1 hour at 5 C. The mixture was allowed to warm to room temperature, held an additional 0.5 hour at room temperature, then filtered. The filtered-off solids were washed with benzene and the washings combined with filtrate. The desired product O-(3,5,6-trichloro-2-pyridyl) ethylphosphonochloridothionate was not isolated but was left in solution for further reaction.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6515-38-4, 3,5,6-Trichloropyridin-2(1H)-one.

Reference:
Patent; Velsicol Chemical Corporation; US4226859; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem