Category: 65169-38-2

Xiao, Qing et al. published their research in Wuhan Gongcheng Daxue Xuebao in 2008 | CAS: 65169-38-2

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C7H5ClN2

Synthesis of 2-chloro-3-amino-4-methylpyridine oxychloride cement was written by Xiao, Qing;Liu, Anchang;Tan, Zhenyou;Liu, Fang. And the article was included in Wuhan Gongcheng Daxue Xuebao in 2008.Synthetic Route of C7H5ClN2 This article mentions the following:

2-Chloro-3-amino-4-methylpyridine was synthesized with 4,4-dimethoxy-2-butanone and malononitrile as raw material by Knoevenagel condensation, cyclization, chlorination, hydrolysis and Hoffman reaction, and the overall yield was 57.3% (mol). The objective compound was characterized by IR and 1H NMR. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2Synthetic Route of C7H5ClN2).

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C7H5ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morisawa, Yasuhiro et al. published their research in Journal of Medicinal Chemistry in 1978 | CAS: 65169-38-2

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 65169-38-2

Studies on anticoccidial agents. 12. Synthesis and anticoccidial activity of methyl-2(6)-nitro- and -3(5)-nitropyridinecarboxamides was written by Morisawa, Yasuhiro;Kataoka, Mitsuru;Sakamoto, Toshiaki;Nagahori, Hitoshi;Kitano, Noritoshi;Kusano, Kenichi. And the article was included in Journal of Medicinal Chemistry in 1978.Product Details of 65169-38-2 This article mentions the following:

Twelve methyl-2-nitro- and 9 methyl-3-nitropyridinecarboxamides were prepared and tested in vivo for anticoccidial activity against Eimeria鑱?em>tenella. Almost all the compounds were active, with optimal activity shown by 5-methyl- (I) [65169-65-5] and 6-methyl-2-nitroisonicotinamide (II) [60780-18-9], which were as potent as 2-nitroisonicotinamide. At least 1 H atom adjacent to the NO2 group is important for anticoccidial activity and a Me group adjacent to the CONH2 function sometimes enhances activity. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2Product Details of 65169-38-2).

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 65169-38-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem