Category: 65189-15-3

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65189-15-3, name is 5,6-Dichloronicotinonitrile, molecular formula is C6H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 5,6-Dichloronicotinonitrile

b) 5,6-Dichloro-pyridine-3-amidoxime The title compound was prepared from 5,6-dichloro-pyridine-3-carbonitrile (257 mg, 1.485 mmol) and 50 wt % hydroxylamine (96.0 muL, 1.57 mmol) similar to Example 36c, and yielded 234 mg (76%) of product as a light yellow solid. 1H NMR (DMSO-d6): 10.11 (s, 1H), 8.66 (d, J=2.20 Hz, 1H), 8.29 (d, J=1.93 Hz, 1H), 6.12 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 65189-15-3.

Reference:
Patent; Cai, Sui Xiong; Zhang, Han-Zhong; Drewe, John A.; Reddy, P. Sanjeeva; Kasibhatla, Shailaja; Kuemmerle, Jared Daniel; Ollis, Kristin P.; US2003/45546; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65189-15-3, name is 5,6-Dichloronicotinonitrile, molecular formula is C6H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H2Cl2N2

A mixture of 5,6-dichloro-nicotinonitrile (Bionet GC-0755, 500 mg, 2.89 mmol) and ethanolamine (0.87 ml_, 14.45 mmol) was prepared in anhydrous dioxane (5 ml.) and heated at 800C for 24 hours. The reaction mixture was diluted with MTBE (50 ml.) and washed with water (2×25 ml.) and brine (25 ml). The aqueous layers were extracted with MTBE (50 ml_).The organic layers were combined, dried (Na2SC>;4) and concentrated under reduced pressure to give the title compound as a white powder (510 mg, 89%). HPLC (Method A), Rt:1.9 min (purity: 99.9%). UPLC/MS, M-(ESI): 196.0.

With the rapid development of chemical substances, we look forward to future research findings about 65189-15-3.

Reference:
Patent; MERCK SERONO S.A.; QUATTROPANI, Anna; GERBER, Patrick; DORBAIS, Jerome; WO2010/100142; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65189-15-3, 5,6-Dichloronicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 65189-15-3, blongs to pyridine-derivatives compound. Product Details of 65189-15-3

(a) tert-Butyl 4-(3-cWoro-5-cyanopyridin-2-yl)piperazine -1-carboxylate; 5,6-Dichloronicotinonitrile (5.00 g, 28.90 mmol, made in according to (JPN patent WO-95- JP587)), 1-Boc-piperazine (8.08 g, 43.4 mmol) and DIPEA (15.1 mL, 86.7 mmol) were suspended in DMA (50 mL) and heated at 120 C for 18 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure to afford the crude material. EPO The crude material was partitioned between DCM (300 mL) and saturated aqueous NaHCO3 (150 mL) and the organics separated. The organics were washed with water (150 mL) and then dried (Mg5O^ and concentrated under reduced pressure to afford the crude product.Flash chromatography (DCM) gave tert-butyl 4-(3-chloro-5-cyanopyridin-2-yl)piperazine-1- carboxylate as a solid. Yield: 11.2O g (120 %) The product was contaminated with DMA. 1HNMR (400 MHz, CDCl3): 6 1.49 (9H, s), 3.52-3.62 (8H, m), 7.76 (1H, s), 8.39 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65189-15-3, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2006/73361; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 65189-15-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 65189-15-3, name is 5,6-Dichloronicotinonitrile. A new synthetic method of this compound is introduced below.

Example 3 5-Chloro-2-methylthio-3-pyridinecarbonitrile STR11 5,6-Dichloro-3-pyridinecarbonitrile (1.73 g, 0.01 mol) was dissolved with stirring in dimethyl sulphoxide (25 mL) and sodium methanethiolate (0.77 g, 0.011 mol) added. The reaction mixture was stirred at room temperature for two hours and poured onto ice (100 g). The mixture was extracted with dichloromethane (50 mL), and the organic extract washed with water (100 mL), and brine, and dried over anhydrous sodium sulphate. Evaporation of the solvent under reduced pressure and recrystallisation of the residue from ethyl acetate:hexane gave the desired product (1.3 g, 71%) as a cream solid, MP 147-9 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,65189-15-3, 5,6-Dichloronicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Kirby; Neil V.; Morrison; Irene M.; Canada; Emily J.; Pieczko; Mary E.; Gustafson; Gary D.; Cooper; David H.; Adamski; Jenifer L.; Mathieson; John T.; Galka; Christopher S.; US6133294; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem