Category: 65515-28-8

Synthetic Route of 65515-28-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65515-28-8, name is Methyl 2,6-dichloronicotinate, molecular formula is C7H5Cl2NO2, molecular weight is 206.03, as common compound, the synthetic route is as follows.

A 250 mL eggplant flask was sequentially charged with methyl 2,6-dichloronicotinate (2.06 g, 10 mmol), 4-(tertbutyl)phenol (1.50 g, 10mmol), and 12 mL of N, N-dimethylformamide for dissolving them. Triethylamine (1.80 mL, 13mmol) was added dropwise under stirring at room temperature, and after completion of the dropwise addition, triethylenediamine (168 mg, 1.50 mmol) was added. The mixture was stirred at room temperature for 4-5 hours and the solutionchanged from clear to turbid. Thin layer chromatography [V (petroleum ether) / V (ethyl acetate) = 6/1] detected thatmost of the raw material disappeared. Then, 1.30 mL of HOAc, 25 mL of isopropanol and 15 mL of ice water weresequentially added while the solution changed from turbid to clear, and stirred at room temperature for 0.5 hour. 40 mLof water was slowly dropwise added, and after completion of the dropwise addition, stirred at room temperature for 2hours. A large number of white solid precipitated and was filtered. The filter cake was washed with a mixed solution ofisopropyl alcohol / water = 1: 1 and dried under vacuum at 50 C for 8 hours to obtain 2.60 g of methyl 6-(4-(tertbutyl)phenoxy)-2-chloronicotinate as a solid, 81.50%

Statistics shows that 65515-28-8 is playing an increasingly important role. we look forward to future research findings about Methyl 2,6-dichloronicotinate.

Reference:
Patent; Shenyang Sunshine Pharmaceutical Co., Ltd.; ZHOU, Yunlong; CAI, Suixiong; WANG, Guangfeng; JIAO, Lingling; MIN, Ping; JING, Yu; GUO, Ming; (44 pag.)EP3275881; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65515-28-8, name is Methyl 2,6-dichloronicotinate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H5Cl2NO2

[Example 24] Synthesis of 2-chloro-6-phenyl-nicotinic acid methyl ester To the mixture of 2,6-dichloro-nicotinic acid methyl ester (4.0 g, 19 mmol) synthesised in Example 23 and tetrahydrofuran (39 ml), phenyl boronic acid (2.5 g, 19 mmol), potassium carbonate (8.0 g, 58 mmol), and tetrakis(triphenylphosphine)palladium(0) (1.2 g, 0.97 mmol) were added, and the obtained reaction mixture was stirred for 16 hours while being heated to reflux. The reaction mixture was cooled to room temperature, and then insoluble matter was removed by filtration. The solvents were evaporated under reduced pressure from the filtrate, and then water and ethyl acetate were added to the obtained residue, followed by extraction. The organic layer and the aqueous layer were separated, and the aqueous layer was further extracted using ethyl acetate. The organic layers were mixed, washed with saturated saline, and dried using anhydrous sodium sulfate. The solvents were evaporated under reduced pressure, and the obtained residue was purified with silica gel column chromatography (heptane: ethyl acetate = 10:1 to 3:1). The obtained crude compound was recrystallized using the mixed solvent of heptane-diethyl ether, thereby obtaining the entitled compound (2.2 g, 47%). 1H-NMR Spectrum (CDCl3) delta(ppm): 3.98(3H, s), 7.46-7.53(3H, m), 7.74(1H, d, J=8.0Hz), 8.04-8.08(2H, m), 8.25(1H, d, J=8.0Hz)

With the rapid development of chemical substances, we look forward to future research findings about 65515-28-8.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2062901; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65515-28-8, Methyl 2,6-dichloronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Methyl 2,6-dichloronicotinate, blongs to pyridine-derivatives compound. Application In Synthesis of Methyl 2,6-dichloronicotinate

A 250 mL eggplant flask was sequentially charged with methyl 2,6-dichloronicotinate (3.09 g, 15 mmol), 4-methoxyphenol (1.86 g, 15mmol), and 18 mL of N, N-dimethylformamide for dissolving them. Triethylamine (2.7 ml, 19.5mmol) was added dropwise under stirring at room temperature, and after completion of the dropwise addition, triethylenediamine (252 mg, 2.25 mmol) was added. The mixture was stirred at room temperature for 4-5 hours and the solutionchanged from clear to turbid. Thin layer chromatography [V (petroleum ether) / V (ethyl acetate) = 6/1] detected thatmost of the raw material disappeared. Then, 1.30 mL of HOAc, 25 mL of isopropanol and 15 mL of ice water weresequentially added while the solution changed from turbid to clear, and stirred at room temperature for 0.5 hour. 40 mLof water was slowly dropwise added, and after completion of the dropwise addition, stirred at room temperature for 2hours. A large number of white solid precipitated and was filtered. The filter cake was washed with a mixed solution ofisopropyl alcohol / water = 1: 1 and dried under vacuum at 50 C for 8 hours to obtain 4.05 g of methyl 2-chloro-6-(4-methoxyphenoxy) nicotinate as a solid, 91.84%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,65515-28-8, Methyl 2,6-dichloronicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Shenyang Sunshine Pharmaceutical Co., Ltd.; ZHOU, Yunlong; CAI, Suixiong; WANG, Guangfeng; JIAO, Lingling; MIN, Ping; JING, Yu; GUO, Ming; (44 pag.)EP3275881; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 65515-28-8, name is Methyl 2,6-dichloronicotinate, the common compound, a new synthetic route is introduced below. Recommanded Product: 65515-28-8

A solution of 2,6-dichloronicotinic acid methyl ester (2.39 g, 11.6 mmol) and NaOMe (800 rog, 14.06 mmol) in THF (15 mL) was stirred at ambient temperature for 3 days. The reaction mixture was quenched by adding 10 mL of 10% NH4Cl solution and extracted with ether. The combined organic layers was dried over anhydrous Na2SO4 and concentrated to afford an unseparable mixture (1.7 g), containing 6-chloro-2-methoxynicotinic acid methyl ester.

The synthetic route of 65515-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XENON PHARMACEUTICALS INC.; WO2006/14168; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 65515-28-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 65515-28-8, name is Methyl 2,6-dichloronicotinate. A new synthetic method of this compound is introduced below.

A 250 mL eggplant flask was sequentially charged with methyl 2,6-dichloronicotinate (8.24 g, 40 mmol), 4-bromophenol (6.92 g,40 mmol), and 50 mL of N, N-dimethylformamide for dissolving them. Triethylamine (7.2 mL, 52mmol) was added dropwise under stirring at room temperature, and after completion of the dropwise addition, triethylenediamine (672 mg, 6 mmol) was added. The mixture was stirred at room temperature for 4-5 hours and the solutionchanged from clear to turbid. Thin layer chromatography [V (petroleum ether) / V (ethyl acetate) = 6/1] detected thatmost of the raw material disappeared. Then, 1.30 mL of HOAc, 25 mL of isopropanol and 15 mL of ice water weresequentially added while the solution changed from turbid to clear, and stirred at room temperature for 0.5 hour. 40 mLof water was slowly dropwise added, and after completion of the dropwise addition, stirred at room temperature for 2hours. A large number of white solid precipitated and was filtered. The filter cake was washed with a mixed solution ofisopropyl alcohol / water = 1: 1 and dried under vacuum at 50 C for 8 hours to obtain 11.48 g of methyl 6-(4-bromophenoxy)-2-chloronicotinate as a solid, 83.92%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65515-28-8, its application will become more common.

Reference:
Patent; Shenyang Sunshine Pharmaceutical Co., Ltd.; ZHOU, Yunlong; CAI, Suixiong; WANG, Guangfeng; JIAO, Lingling; MIN, Ping; JING, Yu; GUO, Ming; (44 pag.)EP3275881; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 65515-28-8, Adding some certain compound to certain chemical reactions, such as: 65515-28-8, name is Methyl 2,6-dichloronicotinate,molecular formula is C7H5Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 65515-28-8.

5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-3-methyl-3H-benzooxazol-2-one (157 mg, obtained in Example 172) was added to a solution of methyl-2,6-dichloropyridine-3-carboxylate (81 mg, [CAS Reg. No. 65515-28-8]) in DMF (3 mL) followed by the addition of triethylamine (0.071 mL). Stirring was continued for 10 minutes at r.t. Then 1,4-diazabicyclo[2.2.2]octane (7 mg) was added. The mixture was stirred over night at r.t. The reaction mixture was poured into water, extracted with ethyl acetate and the organic layer was washed with brine, dried over Na2SO4 and evaporated. The residue was purified by flash chromatography (silica gel, gradient of heptane in ethyl acetate) to give the desired compound as a colorless foam (195 mg, 87%). MS (neg. ion, m/e)=569.2 [(M-H)-].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 65515-28-8, Methyl 2,6-dichloronicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249124; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65515-28-8, Methyl 2,6-dichloronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A 250 mL eggplant flask was sequentially charged with methyl 2,6-dichloronicotinate (4.12g, 20 mmol), [1,1?-biphenyl]-4-phenol (3.40 g, 20 mmol), and 24 mL of N, N-dimethylformamide for dissolving them. Triethylamine (3.8 mL,26 mmol) was added dropwise under stirring at room temperature, and after completion of the dropwise addition, triethylenediamine (336 mg, 3 mmol) was added. The mixture was stirred at room temperature for 4-5 hours and the solutionchanged from clear to turbid. Thin layer chromatography [V (petroleum ether) / V (ethyl acetate) = 6/1] detected thatmost of the raw material disappeared. Then, 1.30 mL of HOAc, 25 mL of isopropanol and 15 mL of ice water weresequentially added while the solution changed from turbid to clear, and stirred at room temperature for 0.5 hour. 40mLof water was slowly dropwise added, and after completion of the dropwise addition, stirred at room temperature for 2hours. A large number of white solid precipitated and was filtered. The filter cake was washed with a mixed solution ofisopropyl alcohol / water = 1: 1 and dried under vacuum at 50 C for 8 hours to obtain 5.66 g of methyl 6-([1,1?-biphenyl]-4-oxo)-2-chloronicotinate as a solid, 83.24%

The synthetic route of 65515-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenyang Sunshine Pharmaceutical Co., Ltd.; ZHOU, Yunlong; CAI, Suixiong; WANG, Guangfeng; JIAO, Lingling; MIN, Ping; JING, Yu; GUO, Ming; (44 pag.)EP3275881; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 65515-28-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65515-28-8, name is Methyl 2,6-dichloronicotinate, molecular formula is C7H5Cl2NO2, molecular weight is 206.03, as common compound, the synthetic route is as follows.

step 1 (S ) -6-chloro-2- [1- (4-fluorophenyl) ethylamino] methyl nicotinatewas dissolved 2,6-dichloro-nicotinic acid methyl ester 5.0 g N, the N- dimethylformamide 50 ml, (S) – (-) – 1- (4-fluorophenyl) ethylamine 4.39 g, N, N-diisopropylethylamine 6.27g and 4-dimethylaminopyridine 150mg was added, and stirred for 24 hours at 60 C..The reaction mixture was cooled, diluted with ethyl acetate, washed successively with water and saturated brine, and dried over magnesium sulfate.Under reduced pressure, the solvent was distilled off, the resulting residue was purified by silica gel column chromatography to give the title compound 2.83g as a white powder.

Statistics shows that 65515-28-8 is playing an increasingly important role. we look forward to future research findings about Methyl 2,6-dichloronicotinate.

Reference:
Patent; NIPPON SHINYAKU COMPANY LIMITED; FUJIHARA, HIDETAKA; ASAKI, TETSUO; HORI, KATSUTOSHI; NAITO, HARUNA; (146 pag.)JP5668756; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65515-28-8, Methyl 2,6-dichloronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 65515-28-8, blongs to pyridine-derivatives compound. SDS of cas: 65515-28-8

5.58 g (111 mmol) of hydrazine · monohydrate was added to a mixed solution of 11.5 g (55.8 mmol) of 2,6-dichloronicotinic acid methylate and 150 ml of dioxane at room temperature. After the addition was completed, the reaction mixture was stirred at room temperature for 18 hours. After completion of the stirring, water was added to stop the reaction, and the solvent in the reaction solution was distilled off under reduced pressure. The precipitated solid was washed with water and collected by filtration to obtain 10.7 g of the objective compound as a yellow solid.

The synthetic route of 65515-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nissan Chemical Industries, Ltd.; Nakaya, Kiyohiko; Tanima, Daisuke; Inaba, Masamitsu; MiyaKaku, Hiroki; Furuhashi, Takayuki; Maeda, Kanenari; Ikeda, Eitatsu; (181 pag.)JP2018/76298; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 65515-28-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65515-28-8, name is Methyl 2,6-dichloronicotinate. This compound has unique chemical properties. The synthetic route is as follows.

A 2.5 M hexane solution of BuLi (32.6 mL, 82 mmol) was added dropwise to a solution of diisopropylamine (12.11 mL, 85 mmol) in THF (100 mL) at -78 0C. The mixture was stirred at 0 0C for 15 min and cooled to -78 0C. Acetonitrile (4.26 mL, 82 mmol) was added dropwise. The solution gradually turned to milky white. After 1 h at -78 0C, methyl 2,6-dichloronicotinate (7.00 g, 34.0 mmol) in THF (25 mL) was added dropwise. The flask was rinsed with THF (5 mL) and added. After 1 h at -78 0C, the mixture was quenched with brine (100 mL), acidified to pH~l and extracted with EtOAc (3×100 mL). The combined extracts were washed with brine (50 mL), dried (MgSO4) and concentrated. Silica gel chromatography, eluting with 0- 5% methanol in CH2Cl2, gave the desired product as yellow solid (4.6374 g, 64% yield). MS (ES+) m/z: 215 (M+H); LC retention time: 2.45 min (analytical HPLC Method A).

According to the analysis of related databases, 65515-28-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/100171; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem