Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 65515-33-5, name is 6-Chloro-2-methoxynicotinic acid. A new synthetic method of this compound is introduced below., Safety of 6-Chloro-2-methoxynicotinic acid
To an oven-dried 40 mL vial was added 6-chloro-2-methoxynicotinic acid (2.1 equiv.) , 2,2?- (2,2?-dichloro-[l,r-biphenyl]-3,3?-diyl)bis(4,4,5,5-tetramethyl-l,3,2-dioxaborolane), potassium carbonate (3.0 equiv.), Pd(dppf)Ch (10 mol %), dimethylformamide (0.2M), and water (10 vol %). The contents of the vial were sparged with nitrogen for 30 seconds then heated to 90 C for 45 minutes. After cooling to room temperature, the mixture was purified by HPLC to yield 6,6?-(2,2?-dichloro-[l,l?- biphenyl]-3,3?-diyl)bis(2-methoxynicotinic acid).
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Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; CHO, Aesop; DU, Zhimin; GRAUPE, Michael; LAD, Lateshkumar Thakorlal; MACHICAO TELLO, Paulo A.; MEDLEY, Jonathan William; METOBO, Samuel E.; MUKHERJEE, Prasenjit Kumar; NADUTHAMBI, Devan; PARKHILL, Eric Q.; PHILLIPS, Barton W.; SIMONOVICH, Scott Preston; SQUIRES, Neil H.; WANG, Peiyuan; WATKINS, William J.; XU, Jie; YANG, Kin Shing; ZIEBENHAUS, Christopher Allen; (300 pag.)WO2019/204609; (2019); A1;,
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