Category: 6602-32-0

Electric Literature of 6602-32-0 ,Some common heterocyclic compound, 6602-32-0, molecular formula is C5H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Diisopropyl azodicarboxylate (4.65 mL, 24 mmol) was added slowly to a dioxane(200 mL) solution of 2-bromo-pyridin-3-ol (3.50 g, 20 mmol), 3-aminopropanol (1.67 mL, 22 mmol) and triphenylphosphine (6.30 g, 24 mmol) at 10 0C. After stirring the mixture for 30 min at this temperature, it was refluxed for 18 h Upon cooling, the volatiles were evaporated and the residue was purified by chromatography (silica, 3% MeOH in CH2Cl2 then 5% (2M NH3 in MeOH) in CH2Cl2 to afford the title compound (3.19 g, 69%). 1U NMR (300 MHz, CDCl3, delta): 7.98 (dd, J =4.5, 1.8 Hz, IH), 7.23 (dd, J =4.5, 8.2 Hz, IH), 7.15 (dd, J =I .8, 8.2 Hz, IH), 4.15 (t, J =6.0 Hz, 2H), 2.98 (t, J =6.6 Hz, 2H), 2.00 (m, 2H). MS (ESI): m/e 231 and 233 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6602-32-0, 2-Bromo-3-hydroxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2008/9122; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6602-32-0, name is 2-Bromo-3-hydroxypyridine, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6602-32-0

EXAMPLES; Example 1; 2-Bromo-3-hydroxy-6-iodopyridine; To a mixture of 14g of 2-bromo-3-hydroxypyridine (80.5 mmol), and 22.3g of K2CO3 (161 mmol) in 180 mL of water at room temperature was added 21. 0g of 12 (82. 7 mmol) in one portion. The mixture was stirred at room temperature for 2h then carefully neutralized with 3N HC1 (aq) to pH = 6. The solid was collected by vacuum filtration and washed with water (100 mL), 2M aqueous sodium bisulfite (50 mL), and water (100 mL). The solid was dried in vacuo to give 16. lg of 2-bromo-3-hydroxy-6-iodopyridine as a tan solid. IH NMR (300 MHz, MeOD) 5 7.57 (d, J=8.3Hz, 1H), 6.95 (d, J=8.3Hz, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 6602-32-0.

Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2005/61458; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6602-32-0, 2-Bromo-3-hydroxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H4BrNO, blongs to pyridine-derivatives compound. COA of Formula: C5H4BrNO

6 g (87.25 mmol) of 1H-pyrazole (1H-pyrazole, a1) 16.86 g (95.98 mmol) of 2-bromopyridin-3-ol, b,25.685 g (185.843 mmol) of K2CO3,0.72 g (3.75 mmol) CuI,L-proline(L-proline) 0.94 g (8.16 mmol)And dimethyl sulfoxide (DMSO) And the mixture was stirred in a nitrogen atmosphere for two days.As a result, 5.6 g (40% yield) of ligand (III) was obtained as a white solid.

The synthetic route of 6602-32-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dankook UniversityAcademicCooperation; Lee, Jun Yeop; Oh, Chan Suk; (18 pag.)KR101627893; (2016); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem