Category: 6602-33-1

Synthesis of a novel optically active C₂-symmetric 2,2′-bipyridine was written by Bolm, Carsten;Ewald, Martina;Zehnder, Margareta;Neuburger, Markus A.. And the article was included in Chemische Berichte in 1992.SDS of cas: 6602-33-1 This article mentions the following:

Optically active 2,2′-bifuropyridine (S,S)-I was synthesized by radical cyclization and a nickel(0)-mediated coupling of enantiomerically pure bromopyridine (S)-II. Palladium, copper, and cobalt complexes of I were prepared The solid-state structures of meso–I and III were determined by x-ray crystal structure anal. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1SDS of cas: 6602-33-1).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 6602-33-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New synthesis of 2,3,6-trihydroxypyridine was written by Krowicki, Krzysztof. And the article was included in Roczniki Chemii in 1977.Recommanded Product: 2,6-Dibromo-3-hydroxypyridine This article mentions the following:

The K salt of 2,6-dibromo-3-hydroxypyridine was treated with PhCH₂Cl to give 3-benzyloxy-2,6-dibromopyridine which was further reacted with PhCH₂ONa to give 2,3,6-tribenzyloxypyridine (I) in 47% yield. I was treated with H on Pd-BaSO₄ in Ac₂O to give 2,3,6-triacetoxypyridine. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Recommanded Product: 2,6-Dibromo-3-hydroxypyridine).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 2,6-Dibromo-3-hydroxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chemistry of 3-hydroxypyridine. Part 1. Bromination and iodination of 3-hydroxypyridine was written by Koch, Volker;Schnatterer, Stefan. And the article was included in Synthesis in 1990.Synthetic Route of C5H3Br2NO This article mentions the following:

Bromination of 3-hydroxypyridine (I) with Br₂ in aqueous NaOH gave 2-bromo, 2,6-dibromo, and 2,4-dibromo derivatives Iodination of I in aqueous Na₂CO₃ gave 2-iodo, 2,6-diiodo, and 2,4,6-triiodo derivatives Similarly, iodination of 2-bromo-3-hydroxypyridine gave 2-bromo-6-iodo- and 2-bromo-4,6-diiodo-3-hydroxypyridine. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Synthetic Route of C5H3Br2NO).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C5H3Br2NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Syntheses of the piperidine alkaloids (±)-cassine, (±)-spectaline, (±)-spicigerine methyl ester and of (±)-azimic acid and (±)-carpamic acid was written by Hasseberg, Hans Albrecht;Gerlach, Hans. And the article was included in Liebigs Annalen der Chemie in 1989.Formula: C5H3Br2NO This article mentions the following:

The title compounds I, II, III, IV (n = 5, 7), resp., were prepared from 2,6-dibromo-3-pyridinol via coupling of the pyridine V with Grignard agents in presence of dichloro[bis(diphenylphosphino)propane]nickel. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Formula: C5H3Br2NO).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C5H3Br2NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ring transformations in reactions of heterocyclic halo compounds with nucleophiles. XII. Action of potassium amide on 2-bromo-and 2,6-dibromo-3-hydroxypyridine was written by Roelfsema, W. A.;Den Hertog, H. J.. And the article was included in Tetrahedron Letters in 1967.Product Details of 6602-33-1 This article mentions the following:

2-Bromo-3-hydroxypyridine (I) was prepared from 3-ethoxy-2-nitropyridine. I treated 2 hrs. at -33° with an 8-fold molar amount of KNH2 in liquid NH3 yielded 85% pyrrole-2-carboxamide (II), m. 172.5-4.0°, also synthesized from pyrrole-2-carboxylic acid. Similarly 2,6-dibromo-3-hydroxypyridine, prepared from 3-hydroxypyridine, was converted to 80% 5-bromopyrrole-2-carboxamide, m. 136-8°. Apparently the conversion occurs without bond fission between C-2 and C-3 as in the analogous transformations of 3-amino-2-bromopyridine and 3-amino-2-bromoquinoline, but that the pyridine rings are broken between C-3 and C-4 atoms. A tentative reaction scheme for the conversion is given. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Product Details of 6602-33-1).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 6602-33-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem