Category: 667932-24-3

Synthetic Route of 667932-24-3, Adding some certain compound to certain chemical reactions, such as: 667932-24-3, name is 2-Ethynylpyridin-4-amine,molecular formula is C7H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 667932-24-3.

Step E Compound 240 (513 mg) was dissolved in dry dichloromethane (50 mL) and Et3N (0. 786ml, 1.3equiv.) was added under nitrogen. The mixture was cooled in an ice bath and a solution of dichloroacetyl chloride (0.483 mL, [L.] [LEQUIV.)] in dry dichloromethane (5 mL) was added dropwise. The reaction was allowed to warm to room temperature over 6 hours and then diluted with EtOAc, washed with a saturated solution of sodium bicarbonate, dried, filtered and concentrated in vacuo. The crude material was passed through a plug of silica gel, eluted with 1: 1 hexanes/EtOAc. The fractions were concentrated to produce a purple oil that solidified under high vacuum to yield compound 255 (658mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 667932-24-3, 2-Ethynylpyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; WO2004/18463; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 667932-24-3 , The common heterocyclic compound, 667932-24-3, name is 2-Ethynylpyridin-4-amine, molecular formula is C7H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of 3- (2-methoxy-6-trifluoromethylphenyl)-5- (4-aminopyridyl) isoxazole To a solution of [N-HYDROXY- (2-METHOXY-6-TRIFLUOROMETHYLBENZENE)] carboximidoyl chloride (lg, 3. [94MMOL)] and 4-amino-2-ethynylpyridine (310mg, 2. [63MMOL)] in THF was added triethylamine [(550ML,] 3.94mmol). The reaction mixture was stirred at room temperature for one hour and then refluxed for three hours. The mixture was cooled to room temperature, ethyl acetate and water were added. The organic layer was separated, dried over sodium sulfate, filtered and concentrated in vacuo to yield the crude product. The final product [3- (2-METHOXY-6-TRIFLUOROMETHYLPHENYL)-5- (4-AMINOPYRIDYL)] isoxazole (609mg) was obtained by purification with flash chromatography with hexanes: ethyl acetate (4: 1).

The synthetic route of 667932-24-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; WO2004/18463; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem