Category: 670253-37-9

Reference of 670253-37-9 ,Some common heterocyclic compound, 670253-37-9, molecular formula is C5H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A suspension of 4-chloro-5-iodopyridin-2- amine (2.54 g, 10.0 mmol), sodium thiomethoxide (1.40 g, 20.0 mmol), copper(l) iodide (190 mg, 1.00 mmol), potassium carbonate (2.76 g, 20.0 mmol) and ethylene glycol (1.12 ml_, (1026) 20.0 mmol) in I PA (3 ml_) was stirred at 80 C under an N2 atmosphere for 19 h. The reaction mixture was allowed to cool to rt, filtered through Celite and the solids were washed using MeOH (3 x 20 ml_). The combined filtrates were concentrated under reduce pressure and water (30 ml_) was added to the residue. The resulting suspension was extracted with DCM (3 x 20 ml_) using a phase separator. The combined organic phases were concentrated under reduced pressure and the residue was purified by flash (1027) chromatography (20%; then 30%; then 40% EtOAc in cyclohexane (isocratic)) to give the title compound (779 mg, 44%) as an off-white crystalline solid. LCMS (Method A): RT = (1028) 0.41 min, m/z = 175, 177 [M+H]+. 1 H NMR (500 MHz, DMSO-cfe): d 8.01 (s, 1 H), 6.59 (s, 1 H), 6.34 (s, 2H), 2.32 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 670253-37-9, 4-Chloro-5-iodopyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; WHITEHEAD, Steven Kristopher; TREDER, Adam Piotr; PROCTOR, Lauren Emma; SHEPHERD, Steven David; BURKAMP, Frank; COSTA, Joana Rita Castro; O’DOWD, Colin; HARRISON, Timonthy; (333 pag.)WO2019/150119; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 670253-37-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.670253-37-9, name is 4-Chloro-5-iodopyridin-2-amine, molecular formula is C5H4ClIN2, molecular weight is 254.46, as common compound, the synthetic route is as follows.

General procedure: A mixture of 30 (500mg, 2.67mmol), Zn(CN)2 (188mg, 1.60mmol), Pd2(dba)3 (122mg, 0.13mmol), and dppf (148mg, 0.27mmol) was added degassed DMF/ H2O (99:1, 3.1mL). The reaction mixture was heated using conventional heating at 120C for 24h. The resulting mixture was cooled to rt, and sat. aq. NH4Cl/ conc. NH3/H2O (4:1:4, 10mL) was added resulting in precipitation. The mixture was cooled to 0C and filtered. The precipitate was washed with sat. aq. NH4Cl/conc. NH3/H2O (4:1:4, 10mL) and H2O at 5C and dried under vacuum affording the product as dark orange solid (279mg, 78%).

The chemical industry reduces the impact on the environment during synthesis 670253-37-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Petersen, Jette G.; S°rensen, Troels; Damgaard, Maria; Nielsen, Birgitte; Jensen, Anders A.; Balle, Thomas; Bergmann, Rikke; Fr°lund, Bente; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 404 – 416;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 670253-37-9 ,Some common heterocyclic compound, 670253-37-9, molecular formula is C5H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a one-neck round bottom flask, 90.7 g (357.1 mmol) of a 1F compound was added to 500 ml of NMP, and 21.4 g (182.1 mmol) of Zetan(CN)2 was added, followed by rapid addition of 41 g (35.7 mmol) of Pd(PPh3)4, 135 C reaction for 5h. The reaction was completed to give a brown oily liquid. The mixture was slowly poured into 3 L of ice water under stirring, and a large amount of a tan solid was precipitated, which was filtered, washed with water and dried to give Compound 1G

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,670253-37-9, its application will become more common.

Reference:
Patent; Chengdu Huajian Pending Technology Co., Ltd.; Zhang Lei; (14 pag.)CN109928968; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 670253-37-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 670253-37-9 as follows.

Zinc cyanide (0.254 g, 2.17 mmol) and tetrakistriphenylphosphine palladium (0) (0.460 g, 0.394 mmol) were added to a solution of compound 30 (1.00 g, 3.94 mmol) in N-methylpyrrolidinone (10 mL). The reaction mixture was heated under N2(g) to 135 C for 2 h, cooled to room temperature and partitioned between EtOAc (30 mL) and aqueous ammonia solution (0.35%, 50 mL). The organic fraction was separated, washed successively with water (2 × 100 mL) and brine (30 mL), dried (MgSO4) and reduced in vacuo onto SiO2. Column chromatography (SiO2), eluting with 2:1 Petrol-EtOAc to 1:1 Petrol-EtOAc, afforded the title compound16 (0.360 g, 2.35 mmol, 60%) as an off-white solid, m.p. 216-219 C (from EtOH-water); Rf 0.23 (1:1 Petrol-EtOAc); deltaH (300 MHz, DMSO-d6); 8.39 (1H, s, 2-H), 7.38 (2H, br s, 6-NH2), 6.62 (1H, s, 5-H); deltaC (75 MHz, DMSO-d6); 162.7 (6-C), 155.3 (2-C), 143.8 (4-C), 116.6 (3-C), 107.5 (5-C), 95.9 (3-CN); numax/cm-1 (solid); 3424, 3331, 3118, 2224, 1656 and 1591; m/z (EI) 153.0 (100%, M+); (Found M+, 153.0095. C6H4ClN3 requires M 153.0094); LC-MS; RT= 1.32min, m/z (ES+) found MH+, 154.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,670253-37-9, its application will become more common.

Reference:
Article; Yule, Ian A.; Czaplewski, Lloyd G.; Pommier, Stephanie; Davies, David T.; Narramore, Sarah K.; Fishwick, Colin W.G.; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 31 – 38;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 670253-37-9 ,Some common heterocyclic compound, 670253-37-9, molecular formula is C5H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a one-neck round bottom flask, 90.7 g (357.1 mmol) of a 1F compound was added to 500 ml of NMP, and 21.4 g (182.1 mmol) of Zetan(CN)2 was added, followed by rapid addition of 41 g (35.7 mmol) of Pd(PPh3)4, 135 C reaction for 5h. The reaction was completed to give a brown oily liquid. The mixture was slowly poured into 3 L of ice water under stirring, and a large amount of a tan solid was precipitated, which was filtered, washed with water and dried to give Compound 1G

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,670253-37-9, its application will become more common.

Reference:
Patent; Chengdu Huajian Pending Technology Co., Ltd.; Zhang Lei; (14 pag.)CN109928968; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 670253-37-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 670253-37-9 as follows.

Zinc cyanide (0.254 g, 2.17 mmol) and tetrakistriphenylphosphine palladium (0) (0.460 g, 0.394 mmol) were added to a solution of compound 30 (1.00 g, 3.94 mmol) in N-methylpyrrolidinone (10 mL). The reaction mixture was heated under N2(g) to 135 C for 2 h, cooled to room temperature and partitioned between EtOAc (30 mL) and aqueous ammonia solution (0.35%, 50 mL). The organic fraction was separated, washed successively with water (2 × 100 mL) and brine (30 mL), dried (MgSO4) and reduced in vacuo onto SiO2. Column chromatography (SiO2), eluting with 2:1 Petrol-EtOAc to 1:1 Petrol-EtOAc, afforded the title compound16 (0.360 g, 2.35 mmol, 60%) as an off-white solid, m.p. 216-219 C (from EtOH-water); Rf 0.23 (1:1 Petrol-EtOAc); deltaH (300 MHz, DMSO-d6); 8.39 (1H, s, 2-H), 7.38 (2H, br s, 6-NH2), 6.62 (1H, s, 5-H); deltaC (75 MHz, DMSO-d6); 162.7 (6-C), 155.3 (2-C), 143.8 (4-C), 116.6 (3-C), 107.5 (5-C), 95.9 (3-CN); numax/cm-1 (solid); 3424, 3331, 3118, 2224, 1656 and 1591; m/z (EI) 153.0 (100%, M+); (Found M+, 153.0095. C6H4ClN3 requires M 153.0094); LC-MS; RT= 1.32min, m/z (ES+) found MH+, 154.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,670253-37-9, its application will become more common.

Reference:
Article; Yule, Ian A.; Czaplewski, Lloyd G.; Pommier, Stephanie; Davies, David T.; Narramore, Sarah K.; Fishwick, Colin W.G.; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 31 – 38;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 670253-37-9, name is 4-Chloro-5-iodopyridin-2-amine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 4-Chloro-5-iodopyridin-2-amine

A mixture of 4-chloro-5-iodopyridin-2-amine (2.8 g, 1 1 mmol), Pd(PPh3)4 (1.9 g, 1.65 mmol), and Zn(CN)2 (0.7 g, 6.05 mmol) in NMP (30 mL) was heated at 130C for 5 hours. The reaction mixture was cooled to 23C, diluted by H20 (200 mL) and filtered. The solid was purified by silica gel chromatography using Petroleum Ether:EtOAc (3: 1 ) as eluting solvents to afford 2-(3H- imidazo[4,5-b]pyridin-3-yl)acetimidamide as a yellow solid (1.18 g, 70%). MS (ESI) m/z: 154 [M+H]+.

The synthetic route of 670253-37-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BEAUFOUR IPSEN TIANJIN PHARMACEUTICAL CO., LTD; AUVIN, Serge; LAVERGNE, Olivier; CHAO, Qi; CHEN, Yufeng; WO2015/100609; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 670253-37-9, name is 4-Chloro-5-iodopyridin-2-amine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 4-Chloro-5-iodopyridin-2-amine

A mixture of 4-chloro-5-iodopyridin-2-amine (2.8 g, 1 1 mmol), Pd(PPh3)4 (1.9 g, 1.65 mmol), and Zn(CN)2 (0.7 g, 6.05 mmol) in NMP (30 mL) was heated at 130C for 5 hours. The reaction mixture was cooled to 23C, diluted by H20 (200 mL) and filtered. The solid was purified by silica gel chromatography using Petroleum Ether:EtOAc (3: 1 ) as eluting solvents to afford 2-(3H- imidazo[4,5-b]pyridin-3-yl)acetimidamide as a yellow solid (1.18 g, 70%). MS (ESI) m/z: 154 [M+H]+.

The synthetic route of 670253-37-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BEAUFOUR IPSEN TIANJIN PHARMACEUTICAL CO., LTD; AUVIN, Serge; LAVERGNE, Olivier; CHAO, Qi; CHEN, Yufeng; WO2015/100609; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 670253-37-9, name is 4-Chloro-5-iodopyridin-2-amine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 4-Chloro-5-iodopyridin-2-amine

A mixture of 4-chloro-5-iodopyridin-2-amine (2.8 g, 1 1 mmol), Pd(PPh3)4 (1.9 g, 1.65 mmol), and Zn(CN)2 (0.7 g, 6.05 mmol) in NMP (30 mL) was heated at 130C for 5 hours. The reaction mixture was cooled to 23C, diluted by H20 (200 mL) and filtered. The solid was purified by silica gel chromatography using Petroleum Ether:EtOAc (3: 1 ) as eluting solvents to afford 2-(3H- imidazo[4,5-b]pyridin-3-yl)acetimidamide as a yellow solid (1.18 g, 70%). MS (ESI) m/z: 154 [M+H]+.

The synthetic route of 670253-37-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BEAUFOUR IPSEN TIANJIN PHARMACEUTICAL CO., LTD; AUVIN, Serge; LAVERGNE, Olivier; CHAO, Qi; CHEN, Yufeng; WO2015/100609; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 670253-37-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 670253-37-9, name is 4-Chloro-5-iodopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

(Tsuruoka, A., et.al. ibid): Zinc cyanide (0.254 g, 2.17 mmol) and tetrakistriphenylphosphine palladium (0) (0.460 g, 0.394 mmol) were added to a solution of compound ii (1.00 g, 3.94 mmol) in NMP (10 mL). The reaction mixture was heated under N2(g) to 135C for 2 h, cooled to room temperature and partitioned between EtOAc (30 mL) and aqueous ammonia solution (0.35%, 50 mL). The organic fraction was separated, washed successively with water (2 x 100 mL) and brine (30 mL), dried (MgS04) and reduced in vacuo onto Si02. Column chromatography (Si02), eluting with 2: 1 Petrol-EtOAc to 1: 1 Petrol-EtOAc, afforded compound iii. (0.360 g, 2.35 mmol, 60%) as an off-white solid.

According to the analysis of related databases, 670253-37-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William; WO2013/91011; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem