Category: 670253-37-9

Synthetic Route of 670253-37-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 670253-37-9, name is 4-Chloro-5-iodopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-chloro-5-iodo-pyridin-2-ylamine (64.2 g, 0.25 mol) in methanol (1.1 L) and TFA (93.7 mL, 1.26 mol) was added tert-butyl nitrite (150 mL, 1.26 mol) so as to maintain temperature less than 3 C. The resultant mixture was stirred at RT for 1 h then allowed to warm to RT and stirred for 16 h. The reaction was quenched by the careful addition of water then concentrated in vacuo to one-fourth of the volume. The resultant residue was treated with water (1 L) and the precipitate formed collected by filtration and dried in vacuo at 35 C. to give the title compound (62.3 g, 92%). Contains 16% impurity. 1H NMR 400 MHz (DMSO-d6) delta: 8.56 (1H, s), 7.20 (1H, s), 3.86 (3H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 670253-37-9, 4-Chloro-5-iodopyridin-2-amine.

Reference:
Patent; Genentech, Inc.; US2012/245144; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 670253-37-9, name is 4-Chloro-5-iodopyridin-2-amine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Chloro-5-iodopyridin-2-amine

In a one-neck round bottom flask, 90.7 g (357.1 mmol) of compound IF was added to 500 ml of NMP, and 21.4 g (182.1 mmol) of Zn(CN)2 was added, and 41 g (35.7 mmol) of Pd(PPh3)4 was quickly added, reacted at 135C for 5 h. After the reaction was completed, a brown oily liquid was given. The reaction mixture was slowly poured into 3 L of ice water under stirring, and a large amount of tan solid was precipitated, filtered, washed with water and dried to give compound 1G, ESI-MS m/z: 154.2 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 670253-37-9, 4-Chloro-5-iodopyridin-2-amine.

Reference:
Patent; Shanghai Zheye Biotechnology Limited-Liability Company; LIU, Jianyu; ZHANG, Haidong; (30 pag.)EP3564242; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem