67058-77-9 | Pyridine-derivatives

Some scientific research about 3-Nitro-1H-pyrrolo[2,3-c]pyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67058-77-9, 3-Nitro-1H-pyrrolo[2,3-c]pyridine, other downstream synthetic routes, hurry up and to see.

Related Products of 67058-77-9 ,Some common heterocyclic compound, 67058-77-9, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 3-nitro-1H-pyrrolo[2,3-c]pyridine (250 mg, 1.53 mmol) in DMF (5 mL) was added NaH (60% dispersion in mineral oil, 61 mg, 1.53 mmol). After stirred at 0 C for 10 mi dimethylsulfate (193 mg, 1.53 mmol) was added dropwise. After stirred at 0 C for 3 hrs, the mixture was partitioned in a mixture of ethyl acetate (50 mL) and H20 (50 mL) and the aqueous phase was extracted by ethyl acetate (50 mL x 2). Organic phase was combined, dried over anhydrous Na2SO4, and evaporated in vacuum. The residue was purified by flash column (ACN in water: 5% to 50%) to afford 1-methyl-3-nitro-1H-pyrrolo[2,3-c]pyridine (30 mg, 11%) as a white solid. ?H NIVIR (400 IVIHz, CD3OD): oe = 8.94 (d, J = 0.8 Hz, 1H), 8.61 (s, 1H), 8.43 (d, J = 5.6 Hz, 1H), 8.12 (dd, J= 5.2, 0.8 Hz, 1H), 4.06 (s, 3H). MS: m/z 178.0 (M+H).

Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 3-Nitro-1H-pyrrolo[2,3-c]pyridine

Sources of common compounds: 3-Nitro-1H-pyrrolo[2,3-c]pyridine

According to the analysis of related databases, 67058-77-9, the application of this compound in the production field has become more and more popular.

Application of 67058-77-9, Adding some certain compound to certain chemical reactions, such as: 67058-77-9, name is 3-Nitro-1H-pyrrolo[2,3-c]pyridine,molecular formula is C7H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67058-77-9.

To a solution of 3-nitro-1H-pyrrolo[2,3-c]pyridine (200 mg, 1.23 mmol) in MeOH (20 mL) was added 10% Pd/C (130 mg, 0.12 mmol). After stirred at balloon hydrogen atmosphere for 2 hrs, the mixture was filtered. The filtrate was evaporated in vacuum to give 1H- pyrrolo[2,3-c]pyridin-3-amineas a crude product which was used for next step without further purification.

According to the analysis of related databases, 67058-77-9, the application of this compound in the production field has become more and more popular.

Sources of common compounds: 67058-77-9

The synthetic route of 67058-77-9 has been constantly updated, and we look forward to future research findings.

Reference of 67058-77-9 , The common heterocyclic compound, 67058-77-9, name is 3-Nitro-1H-pyrrolo[2,3-c]pyridine, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 3 -nitro- 1H-pyrrolo [2,3 -c]pyridine (250 mg, 1.53 mmol) in DIVIF (5 mL) was added NaH (60% dispersion in mineral oil, 61 mg, 1.53 mmol). After stirred at 0 C for 10 mm, the mixture was added dimethylsulfate (193 mg, 1.53 mmol) dropwise. After stirred at 0 C for 3 hrs, the mixture was partitioned in a mixture of H20 (50 mL) and EA (50 mL). The aqueous phase was then extracted by EA (50 mL x 2). Organic phase was combined, dried over anhydrous Na2SO4, and evaporated in vacuum. The residue was washed with MeOH (5 mL) to afford 6-methyl- 3-nitro-6H-pyrrolo[2,3-c]pyridine (70 mg, 26%) as a yellow solid. ?H NIVIR (400 IVIHz, DMSO-d6):oe = 9.09 (s, 1H), 8.65 (s, 1H), 8.25 (dd, J 6.8, 1.2 Hz, 1H), 8.14 (d, J= 6.8 Hz, 1H), 4.26 (s, 3H). MS: m/z 178.0 (M+H).

The synthetic route of 67058-77-9 has been constantly updated, and we look forward to future research findings.