Category: 67443-38-3

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 5-Bromo-2-chloro-3-nitropyridine

To a cooled solvent of MeOH (50.0 mL) was added Na (2.90 g, 126.4 mmol) portion-wise, then the mixture was warmed to rt and stirred until Na was all dissolved, then the solution was added to a suspension of 5-bromo-2-chloro-3-nitropyridine (10.0 g, 42.12 mmol, Shanghai long sheng hua gong, china) in MeOH (100 mL) at 0 C. The reaction mixture was stirred at 0 C. for 1 hour, then warmed up to rt and stirred further for 16 hours, then concentrated to 80 mL and quenched with water (100 mL). The precipitate was filtered, washed with water (50 mL*2) and dried under infrared light to give the title compound as a pale yellow solid (9.62 g, 98%). MS (ESI, pos. ion) m/z: 233.0 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 67443-38-3.

Reference:
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine, molecular formula is C5H2BrClN2O2, molecular weight is 237.44, as common compound, the synthetic route is as follows.COA of Formula: C5H2BrClN2O2

General procedure: A mixture of 5-Bromo-2chloro-3-nitropyridine (2) (10mmol), organicamine compound (14mmol), and N,N-diisopropylethylamine (30mmol) in 1,4-dioxane (100mL) was stirred at room temperature for 4h. After the reaction was completed by TLC analysis, the volatiles were removed under reduced pressure. The mixture was extracted with CH2Cl2 (3¡Á60mL) and washed with H2O (3¡Á60mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo.The resulting residue was purified by column chromatography on silica gel (PE: EA=9:1) to obtain theintermediates 3a-j.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67443-38-3, 5-Bromo-2-chloro-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Article; Du, Shan; Li, Wei-Ya; Liu, Wen-Shan; Ma, Yang-Chun; Ma, Ying; Wang, Rui-Rui; Wang, Run-Ling; Yang, Bing; Zhou, Liang; Bioorganic Chemistry; vol. 100; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 67443-38-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine, molecular formula is C5H2BrClN2O2, molecular weight is 237.44, as common compound, the synthetic route is as follows.

Compound A (30.0 g), glycine-tert-butyl ester hydrochloride(23.3 g) and DMA (250 mL) was added triethylamine(38.4 mL) was added dropwise at 50 C. After completion of the dropwise addition,Followed by stirring at 50 C. for 2 hours. To the reaction mixture was added toluene (400 mL)And the mixture was washed with water, 1% hydrochloric acid and water in this order. After drying over sodium sulfate,A toluene solution of compound B was obtained.

Statistics shows that 67443-38-3 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-chloro-3-nitropyridine.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA COMPANY LIMITED; LEE, SHOUKOU; IWAMOTO, KOHEI; (57 pag.)JP2016/132649; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2BrClN2O2

The lambda/-[5-(5-amino-6-chloropyridin-3-yl)thiazol-2-yl]acetamide used as a starting material was prepared as follows :-Using an analogous procedure to that described by K. Jouve and J. Bergman, J. Heterocyclic Chem., 2003, 40, 261 except that one equivalent of lithium chloride was used, 2-amino-5-bromo-3-nitropyridine was converted in 84% yield into 5-bromo-2-chloro-3-nitropyridine; 1H nuMR Spectrum: (CDCl3) 8.37 (IH, d), 8.7 (IH, d); which, in turn, was converted into 3-amino-5-bromo-2-chloropyridine; 1H nuMR Spectrum: (CDCl3) 4.17 (2H, br s), 7.18 (IH, d), 7.85 (IH, d).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 67443-38-3, 5-Bromo-2-chloro-3-nitropyridine.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/129044; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem