Category: 67515-76-8

Reference of 67515-76-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67515-76-8, name is Methyl 5-aminopicolinate. This compound has unique chemical properties. The synthetic route is as follows.

To a N,N-dimethylformamide (20 mL) solution of 5-Amino-2 -nicotinic acid methyl ester (2.31 g) was added iodine (3.09 g) and sodium metaperiodate(1.3 g). The reaction was then heated to 60 0C for 24h. After cooling to room temperature, the reaction was poured into a solution of sodium metabisulfite. The solid thus separated was filtered, washed with water and dried under vacuum to yield 1.6g of the desired compound (Rf: 0.84 min, Condition B, M+H+: 279).

According to the analysis of related databases, 67515-76-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SCIOS, INC.; WO2006/112828; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 67515-76-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67515-76-8, name is Methyl 5-aminopicolinate, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 62 Preparation of methyl 5-fluoropicolinate STR225 The methyl 5-aminopicolinate (2.2 g) is dissolved in 5.5 ml 48% fluoroboric acid and 20 ml 95% ethanol. This mixture is cooled, with stirring, to -3 C. and then 1.81 g n-butyl nitrite added dropwise. After a further one-half hour at -3 C., 0.5 ml n-butyl nitrite is added slowly and stirring continued for one-half hour at 0 C. After adding 20 ml ether carefully, the mixture is rapidly filtered, and the solid washed twice with cold hexane. The solid is suspended in 100 ml heptane, and the suspension slowly heated with stirring. At about 60 C., a vigorous exothermic reaction occurs. Heating is then continued to 80 C. A red oil separates on the sides of the flask. The heptane solution is filtered, and the filtrate concentrated to give the desired product. The red oil is dissolved in water, excess sodium bicarbonate solution added, and the solution extracted with ethyl acetate. The ethyl acetate extract is washed with saturated brine, dried and concentrated. The residue is chromatographed on silica gel and the product, methyl 5-fluoropicolinate, eluted with 1:1-ether:hexane. This material is used directly for the preparation of the picolinic acid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 67515-76-8, Methyl 5-aminopicolinate.

Reference:
Patent; American Cyanamid Company; US4638068; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 67515-76-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67515-76-8, name is Methyl 5-aminopicolinate. This compound has unique chemical properties. The synthetic route is as follows.

To a suspension of methyl 5-aminopicolinate (70mg, 0.460 mmol) in THF (3 mL) was added a solution of LAH (1 M in THF) (0.920 mL, 0.920 mmol) at 0 C. The mixture was allowed to warm to room temperature and stirred overnight. After 16 h, thereaction was quenched with water (0.1 mL) at 0 C. A solution of sodium hydroxide (2N, 0.1 mL) was subsequently added followed by an additional quantity of water (0.3 mL). Magnesium sulfate was added and the mixture was stirred for 1 hour before being filtered over a pad of celite and washed with THF. The filtrate was concentrated in vacuo to afford Intermediate 385A (35 mg, 0.282 mmol, 61.3 % yield) as a yellow solid. Thismaterial was taken on without further purification. LC-MS. Method H, RT = 0.44 mm, MS (ESI)m/z: 125.1 (M+H). ?HNMR(400 MHz, DMSO-d6) 7.80-7.88 (m, 1H), 7.05-7.16 (m, 1H), 6.83-6.96 (m, 1H), 4.88-5.04 (m, 1H), 4.27-4.41 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 67515-76-8, Methyl 5-aminopicolinate.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 67515-76-8, Adding some certain compound to certain chemical reactions, such as: 67515-76-8, name is Methyl 5-aminopicolinate,molecular formula is C7H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67515-76-8.

A mixture of the methyl 5-aminopicolinate (456 mg, 3 mmol), 2-(chloromethyl)oxazole (354 mg, 3 mmol) in H2O (10 ml) was stirred at 80 C. under N2 atmosphere for overnight. The mixture was concentrated to get a residue, which was washed by Prep-TLC to afford methyl 5-(oxazol-2-ylmethylamino)picolinate (140 mg, 20%) as a yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67515-76-8, Methyl 5-aminopicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Acetylon Pharmaceuticals, Inc.; van Duzer, John H.; Mazitschek, Ralph; (23 pag.)US2018/127356; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 67515-76-8, Adding some certain compound to certain chemical reactions, such as: 67515-76-8, name is Methyl 5-aminopicolinate,molecular formula is C7H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67515-76-8.

Reference Example 17 Methyl 5-(tert-butoxycarbonylamino)-6-iodopyridine-2-carboxylate A mixture of methyl 5-aminopyridine-2-carboxylate (2.92 g), iodine (3.9 g) and sodium periodate (1.64 g) in N,N-dimethylformamide (24 mL) was stirred at 60C for 2 days. The reaction mixture was cooled to room temperature. To the reaction mixture was added 10% aqueous sodium sulfite solution, and the resulting mixture was stirred for 10 minutes. The crystals were collected by filtration. The collected crystals were washed with water, and dried under reduced pressure to give methyl 5-amino-6-iodopyridine-2-carboxylate (3.26 g). To sodium hexamethyldisilazide (1.03 mol/L tetrahydrofuran solution, 7.68 mL) was added a solution of methyl 5-amino-6-iodopyridine-2-carboxylate (1 g) in tetrahydrofuran (5 mL) in a dropwise manner at -14C, and the mixture was stirred at the same temperature for 10 minutes. To the mixture was added a solution of di(tert-butyl)dicarbonate (0.82 g) in tetrahydrofuran (3 mL) in a dropwise manner, and the mixture was stirred at the same temperature for 30 minutes. To the reaction mixture was added 1 mol/L hydrochloric acid (13.6 mL), and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. To the residue were added 2-propanol (2.8 mL) and water (3.4 mL), and the mixture was stirred at 80C for 30 minutes, and then stirred at room temperature for 30 minutes. The crystals were collected by filtration. The collected crystals were washed with a mixed solvent (2-propanol/water = 5/6), and dried under reduced pressure to give the title compound (0.82 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67515-76-8, Methyl 5-aminopicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP2143724; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 67515-76-8, Methyl 5-aminopicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

N-Bromosuccinimide (468 mg, 2.63 mmol) was added portion-wise to a 50 o solution of methyl 5-aminopyridine-2-carboxylate (400 mg, 2.6 mmol) in acetonitrile (15 mL), and the reaction mixture was heated at 50 00 overnight. Crude reaction mixtures from six additional small-scale reactions of this transformation were added (total starting material quantity: 760 mg, 5.0 mmol), and the resulting mixture was concentrated invacuo, then purified via silica gel chromatography (Gradient: 2% to 66% ethyl acetate in petroleum ether), providing the product as a red solid. Yield: 150 mg, 0.65 mmol, 13%. 1H NMR (400 MHz, CDCI3) oe 8.23 (5, 1H), 8.16 (5, 1H), 4.61 (brs, 2H), 3.97 (5, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67515-76-8, Methyl 5-aminopicolinate, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; BRODNEY, Michael Aaron; DAVOREN, Jennifer Elizabeth; GARNSEY, Michelle Renee; ZHANG, Lei; O’NEIL, Steven Victor; (174 pag.)WO2016/9297; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 67515-76-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 67515-76-8 as follows.

The substrate 2,4-dichloro-6-hydroxybenzaldehyde (84 mg, 0.44 mmol)Dissolved in 10mL of 1,2-dichloroethane,To the solution was added 5-amino-2-methoxycarbonylpyridine (67 mg, 0.44 mmol)And titanium tetraisopropoxide (250 mg, 0.88 mmol). The reaction solution was stirred under reflux for 4 hours.Cool to room temperature and add 1 drop of acetic acid and sodium cyanoborohydride (83 mg, 1.32 mmol).Continue to reflux and stir overnight. Quenched with water, extracted with dichloromethane, combined, dried,The crude compound 29A (200 mg) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,67515-76-8, its application will become more common.

Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 67515-76-8, Methyl 5-aminopicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H8N2O2, blongs to pyridine-derivatives compound. HPLC of Formula: C7H8N2O2

EXAMPLE 21 Following the procedure of Example 1, but substituting an equivalent amount of methyl 5-amino-picolinate for methyl 2-amino-nicotinate and using pyridine as solvent, maintaining the reaction mixture at 40 C. for seven hours, using methylene chloride as eluent for the chromatography column, methyl 5-(2-acetylthiomethyl-propionamido)-picolinate; m.p. 169-171 C., from ethyl acetate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67515-76-8, Methyl 5-aminopicolinate, and friends who are interested can also refer to it.

Reference:
Patent; Simes, Societa Italiana Medicinalle Sintetici; US4528296; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem