Category: 67625-37-0

Reference of 67625-37-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.67625-37-0, name is Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate, molecular formula is C10H9BrN2O2, molecular weight is 269.0947, as common compound, the synthetic route is as follows.

A stirred solution of ethyl 6-bromoimidazo[l,2-a]pyridine-2-carboxylate(1-6, 4.0 g, 14.86 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (A17, 6.42 g, 25.27 mmol) and KOAc(2.47 gm, 25.27 mmol) in dioxane(100 mL) was degassed with argon for 30 minutes. Then[I,G- Bis(diphenylphosphino)ferrocene]palladium(II) dichloride(0.761 g, 1.04 mmol) was added. The reaction mixture was heated at 90C for 16 h. After completion, reaction mixture quenched with water and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain the crude. This crude washed with 30% diethyl ether in hexane and concentrated the filtrate to offered ethyl 6-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)imidazo[l,2-a]pyridine-2-carboxylate 1-27 as brown gummy liquid. Yield: 7.8 g LC-MS(ES) m/z = 235.09[M+H]+.

The chemical industry reduces the impact on the environment during synthesis 67625-37-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; JUBILANT BIOSYS LIMITED; VADIVELU, Saravanan; RAJAGOPAL, Sridharan; BURRI, Raghunadha Reddy; GARAPATY, Shivani; SIVANANDHAN, Dhanalakshmi; THAKUR, Manish Kumar; NATARAJAN, Tamizharasan; SWAMY, Indu N; NAGARAJU, Nagendra; KANAGARAJ, Subramaniam; MOHD, Zainuddin; SARKAR, Sayantani; SAMANTA, Swapan Kumar; ., Hariprakash; (284 pag.)WO2019/102494; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 67625-37-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67625-37-0, name is Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Preparation 86 6-Aminoimidazo[1,2-a]pyridine-2-carboxamide To a solution of ethyl 6-aminoimidazo[1,2-a]pyridine-2-carboxylate (Preparation 87, 2 g, 0.0074 mol) in MeOH (30 mL) was added ammonia (3 g, 0.044 mol) and the reaction was heated to 100 C. in a sealed vessel for 24 hours. The reaction was cooled and concentrated in vacuo to afford the title compound (1.9 g, 90%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 67625-37-0, Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate.

Reference:
Patent; PFIZER INC.; Fensome, Andrew; Gopalsamy, Ariamala; Gerstenberger, Brian S.; Efremov, Ivan Viktorovich; Wan, Zhao-Kui; Pierce, Betsy; Telliez, Jean-Baptiste; Trujillo, John I.; Zhang, Liying; Xing, Li; (104 pag.)US2016/52930; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 67625-37-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67625-37-0, name is Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 30 (8 g, 29.73 mmol), 2-chlorobenzaldehyde (6.7 ml, 59.58 mmol),2,2-dimethyl-1,3-dioxane-4,6-dione (8.6 g, 59.67 mmol), L-proline (170 mg, 1.48 mmol)and MgSO4 (11 g, 91.39 mmol) in acetonitrile (80 mL) was heated at 90 C for 33 h, followed by 100 C 15h. The reaction cooled to r.t., and the solid filtered off, and washed with methanol (2 x 50 mL). The filtrate was concentrated in vacuo and triturated with diethyl ether (50 mL) and sonicated for 1 0mm and resulting gum was filtered off andrinsed with diethyl ether (2 x 50 mL) yielding the title compound as beige solid (10.2g,76%). 1H NMR (500 MHz, Methanol-d4) oe 8.79 (s, 1H), 7.74 (d, J 7.7 Hz, 1H), 7.67 -7.55 (m, 2H), 7.43 – 7.34 (m, 2H), 7.34 – 7.20 (m, 1H), 5.56 (dd, J 9.5, 6.0 Hz, 1H), 4.35(qt, J 7.4, 3.7 Hz, 2H), 3.70 (dd, J 16.7, 9.5 Hz, 1H), 3.40 (dd, J 16.7, 6.0 Hz, 1H), 1.34(t, J 7.1 Hz, 3H). LCMS (ESj RT 1.24 mm, 45 1.0/453.0 (M+H)t

According to the analysis of related databases, 67625-37-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UCB BIOPHARMA SPRL; SANOFI; DE HARO GARCIA, Teresa; DELIGNY, Michael; HEER, Jag Paul; QUINCEY, Joanna Rachel; XUAN, Mengyang; ZHU, Zhaoning; BROOKINGS, Daniel Christopher; CALMIANO, Mark Daniel; EVRARD, Yves; HUTCHINGS, Martin Clive; JOHNSON, James Andrew; JADOT, Sophie; KEYAERTS, Jean; MAC COSS, Malcolm; SELBY, Matthew Duncan; SHAW, Michael Alan; SWINNEN, Dominique Louis Leon; SCHIO, Laurent; FORICHER, Yann; FILOCHE-ROMME, Bruno; (365 pag.)WO2016/50975; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem