Synthetic Route of 676371-00-9 ,Some common heterocyclic compound, 676371-00-9, molecular formula is C7H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 8.00 g (100 mmol) freshly prepared difluoroacetaldehyde in 560 mL DCM was added 5.30 g (25 mmol) 6-bromoimidazo[1 ,2-a]pyridin-8-amine, 26.49 g (125 mmol) sodium triacetoxy borohydride and 28.5 g (18.56 mL, 250 mmol) TFA and the mixture was stirred for 72 h at rt to give, after working up andpurification, 4.0 g (58 ?) of the title compound. UPLC MS: RT = 0.71 min; m/z (ES+) 277.1 [MH+]; required MW = 276.1. 1 H-NMR (300 MHz ,DMSO-d6), delta [ppm]= 3.69 (2H), 6.36 (1 H), 6.54 (1 H), 7.41 (1 H), 7.77 (1 H), 8.10 (1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,676371-00-9, its application will become more common.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; WENGNER, Antje; NEUHAUS, Roland; SIEMEISTER, Gerhard; WO2012/136531; (2012); A1;,
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