Category: 68470-59-7

Synthetic Route of 68470-59-7 ,Some common heterocyclic compound, 68470-59-7, molecular formula is C7H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sodium azide (48 mg, 073 mmo) was added to a soution of 2(bromomethy 6methypyridne (91 mg, 049 mmo) n dry DMFm). (t8 The reaction mixture was irradiated with microwaves 90 00 for 30 mn. After cooing, water was added and the reaction mixture was extracted with Et20. The organic phase was dried over Na2SO4 and the sovent removed to yied the desred product (33 mg, 46%). 1HNMR (300MHz, CDC3), 6 ppm: 758 (t, J = 8 Hz, IH), 7.13(d, J 8 Hz, 1H), 7.08 (d, J = 8Hz, 1H), 4,43 (s, 2H), 2.54 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 68470-59-7, 2-(Bromomethyl)-6-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; CUEVAS CORDOBES, Felix; ALMANSA-ROSALES, Carmen; GARCIA LOPEZ, Monica; WO2015/91939; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 68470-59-7

(2.0 g, 11.35 mmol), potassium carbonate (2.4 g, 17.03 mmol) and Ib (2.2 g, 11.92 mmol) were added to DMF (20 mL), respectively, and stirred overnight at room temperature.The reaction was poured into water and extracted with EtOAc (100 mL x 2).The organic phase was washed with water and saturated brine, and dried over sodium sulfate.After filtration, the filtrate was concentrated and separated by column chromatography (EtOAc / Pet. Ether, 1/10 to 1/4, v / v) to give the product as pale white solid 1c (1.6 g, 50%)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 68470-59-7, 2-(Bromomethyl)-6-methylpyridine.

Reference:
Patent; Suzhou Xiangshi Pharmaceutical Development Co., Ltd; Bu, Xianyong; Yuehan, Fuchuier; Andongni, Kuzubi; Wu, Leguang; Liu, Shiqiang; (30 pag.)CN105985322; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 68470-59-7 , The common heterocyclic compound, 68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine, molecular formula is C7H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[2-chloro-5-[(E)-N-hydroxy-C-methyl-carbonim idoyl]phenyl]methyl N-methylcarbamate (500 mg, 1 .9 mmol) and 2-(bromomethyl)-6-methylpyridine (720 mg, 3.9 mmol) were dissolved in dimethyl formamide (DMF) (35 mL). Then K2C03 (810 mg, 5.8 mmol) was added and themixture was stirred at room temperature overnight. After the addition of water, the solution was extracted with EtOAc and the organic layer was dried over Na2SO4. Concentration and purification by preparative H PLC yielded in [2-chloro-5-[(E)-C-methyl-N-[(6-methyl-2- pyridyl)methoxy]carbonimidoyl]phenyl]methyl N-methylcarbamate (190 mg, 28%) as a pale white solid and in its Z-isomer (160 mg, 23%) as a white solid.

The synthetic route of 68470-59-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; WINTER, Christian; RHEINHEIMER, Joachim; WOLF, Antje; POONOTH, Manojkumar; TERTERYAN, Violeta; WIEBE, Christine; KREMZOW-GRAW, Doris; ROeHL, Franz; GRAMMENOS, Wassilios; ROHRER, Sebastian Georgios; WIEJA, Andy; ROSENBAUM, Claudia; WO2014/207071; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine, molecular formula is C7H8BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-(Bromomethyl)-6-methylpyridine

Step A: Preparation of 4-methyl-3-[2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-benzoic acid methyl ester To a solution of Intermediate 2 (460 mg, 1.68 mmol) in N,N-dimethylformamide (2 mL) was added 2-(bromomethyl)-6-methylpyridine (312 mg, 1.68 mmol), potassium carbonate (350 mg, 2.53 mmol) and 18-crown-6 (40 mg). The slurry was stirred at ambient temperature for one hour. The reaction was partitioned between ethyl acetate and water. The organic layer was washed with water and brine and dried over magnesium sulfate. The slurry was filtered and concentrated in vacuo. The crude material was purified using normal phase chromatography (ethyl acetate/heptane) to provide the alkylated product as a white semi-solid (100 mg, 16% yield). MS (M+H): 380

With the rapid development of chemical substances, we look forward to future research findings about 68470-59-7.

Reference:
Patent; CONFLUENCE LIFE SCIENCES, INC.; SELNESS, Shaun R.; Devadas, Balekudru; Hockerman, Susan L.; Monahan, Joseph B.; US2013/143906; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 68470-59-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine, molecular formula is C7H8BrN, molecular weight is 186.0491, as common compound, the synthetic route is as follows.

Step B: Preparation of 3 -iodo- 1 -((6-methylpyridin-2-yl)methyl)-4-nitro- 1 H- indazole: To a solution of 3-iodo-4-nitro-lH-indazole (172 mg, 0.596 mmol) in dry DMF (3 mL) under an atmosphere of dry nitrogen was added 2-(bromomethyl)-6-methylpyridine (122 mg, 0.656 mmol) and potassium carbonate (165 mg, 1.19 mmol) with stirring. The mixture was stirred at ambient temperature for 3 days. The reaction mixture was diluted with water (20 mL) and extracted into ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated under reduced pressure. The resulting material was purified using preparative chromatography on silica, eluting with hexane/ethyl acetate (3: 1) to give 3-iodo-l-((6-methylpyridin-2- yl)methyl)-4-nitro-lH-indazole (213 mg).

Statistics shows that 68470-59-7 is playing an increasingly important role. we look forward to future research findings about 2-(Bromomethyl)-6-methylpyridine.

Reference:
Patent; ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; DELISLE, Robert Kirk; HICKEN, Erik James; KENNEDY, April L.; MARESKA, David A.; MARMSATER, Fredrik P.; MUNSON, Mark C.; NEWHOUSE, Brad; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian; WO2012/82689; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem