6854-07-5 | Pyridine-derivatives

Share a compound : 5-Nitro-2-oxo-3-pyridinecarboxylic Acid

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6854-07-5, 5-Nitro-2-oxo-3-pyridinecarboxylic Acid.

Electric Literature of 6854-07-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid, molecular formula is C6H4N2O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

b) 2-Chloro-5-nitro-nicotinic acid 2-Hydroxy-5-nitro-nicotinic acid (2.7 mmol) in a mixture of NJV- dimethylformamide (2.7 mmol) and thionyl chloride (5 ml) was heated at 80 0C for 1 h. The mixture was allowed to cool and concentrated in vacuo. To the resulting residue was added ice-water (20 ml) and with vigorous stirring a precipitate formed. The precipitate was filtered off and dried in a vacuum oven to give a white solid (68%).ESIMS: M-I: found 201 ; expected 201; and1H NMR (300 MHz, DMSO) ? 9.30 (IH, d, H-4), 8.83 (IH, d, H-6).

Reference:
Patent; BIONOMICS LIMITED; WO2008/46135; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Share a compound : 5-Nitro-2-oxo-3-pyridinecarboxylic Acid

Reference:
Patent; BIONOMICS LIMITED; WO2008/46135; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 6854-07-5

With the rapid development of chemical substances, we look forward to future research findings about 6854-07-5.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4N2O5

4b) 2-Chloro-5-nitropyhdin-3-yl phenyl ketone; 18.4 g of the acid prepared in example 4a) is admixed at 25C with 120 ml of thionyl chloride followed by 3 ml of DMF, and subsequently heated at reflux for 3 hours. The excess thionyl chloride is removed under reduced pressure and the yellow solid that remains is dissolved in 100 ml of benzene. This solution is admixed with 4O g of AICI3 at 00C and then stirred at 25C for 16 hours. The reaction mixture is then poured cautiously into cold (partly frozen) concentrated hydrochloric acid; after one hour the mixture is filtered and the organic phase is separated off. The organic phase is washed with hydrochloric acid, dried over sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue is purified by chromatography on silica gel with hexane/10% ethyl acetate. This gives 15 g of the title compound. NMR (300 MHz, DMSO-d6): delta = 7.60 (2H), 7.77 (1 H), 7.87 (2H), 8.95 (1 H), 9.4 (1 H).

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Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAYER HEALTHCARE AKTIENGESELLSCHAFT; WO2009/30725; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 6854-07-5

With the rapid development of chemical substances, we look forward to future research findings about 6854-07-5.

Reference Example 11 Dimethylformamide (4 drops) was added to a solution of 2-hydroxy-5-nitronicotinic acid (5g) in phosphorus oxychloride (10ml). The mixture was stirred at the reflux temperature for 3 hours. Excess solvent was removed by evaporation and the residue was then poured carefully into water, keeping the temperature of the resulting mixture at below 40oC. The mixture was stirred at room temperature for a further 30 minutes then extracted with ethyl acetate. The extracts were washed with water, dried (magnesium sulphate) and evaporated. The resulting residue was triturated with ether/hexane to yield 2-chloro-5-nitronicotinic acid as a pale yellow solid (3.6g), m.p. 123-7oC.

With the rapid development of chemical substances, we look forward to future research findings about 6854-07-5.

Reference:
Patent; RHONE POULENC AGRICULTURE LTD.; EP634413; (1995); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about 6854-07-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6854-07-5, 5-Nitro-2-oxo-3-pyridinecarboxylic Acid, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid, molecular formula is C6H4N2O5, molecular weight is 184.11, as common compound, the synthetic route is as follows.Recommanded Product: 6854-07-5

Step B 2-Methoxy-3-carbomethoxy-5-nitropyridine 2-Hydroxy-3-carboxy-5-nitropyridine was converted to 2-chloro-3-chlorocarbonyl-5-nitropyridine in situ and converted to the title compound by reaction with anhydrous methanol according to the procedure of A. Monge et al J. Het. Chem. (29), 1545 (1992). In a 500 mL was added starting material (10.2 g, 54 mmol) in 200 mL of chlorobenzene.

Reference:
Patent; Merck & Co., Inc.; US5750549; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Simple exploration of 6854-07-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6854-07-5, 5-Nitro-2-oxo-3-pyridinecarboxylic Acid, other downstream synthetic routes, hurry up and to see.

Related Products of 6854-07-5, Adding some certain compound to certain chemical reactions, such as: 6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid,molecular formula is C6H4N2O5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6854-07-5.

A suspension of Part A(l) compound (7.0 g, 38 mmol) in phosphorus oxychloride (20 mL) was heated at reflux for 2 h, cooled to RT, and added slowly to H2O (100 mL) with stirring, maintaining the temperature below 40’C with added ice. Following addition, the mixture was stirred at RT for 30 min, whereupon a precipitate formed. The mixture was extracted with Et2O/THF (2:1, 2 x 200 mL), and the combined organic extracts were washed with brine (100 mL), dried over Na2SO4, and concentrated to give an oily yellow solid. The crude product was taken up in hot Et2O/hexane (1:1, 200 mL), filtered, and the filtrate was concentrated to give title compound (5.78 g, 75%) as a yellow solid (mp 140-141C, lit mp 142-143C).

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; EP904262; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 6854-07-5

Statistics shows that 6854-07-5 is playing an increasingly important role. we look forward to future research findings about 5-Nitro-2-oxo-3-pyridinecarboxylic Acid.

Related Products of 6854-07-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid, molecular formula is C6H4N2O5, molecular weight is 184.11, as common compound, the synthetic route is as follows.

b) 2-Chloro-5-nitronicotinic acid A solution of 2-hydroxy-5-nitronicotinic acid (9.2 g, 0.05 mol) in phosphorus oxychloride (25 ml) was refluxed for 5 hours. The solvent was removed in vacuo and the residue dissolved in a mixture of tetrahydrofuran and ether. After cooling the solution in an ice bath, water was cautiously added dropwise with stirring until a clean separation of layers was obtained. The organic layer was washed with water and a saturated sodium chloride solution, dried (anhydrous magnesium sulfate) and concentrated. Recrystallization from ether gave 6.94 g (69% of theory) of pure product, m.p. 135 C. (dec).

Statistics shows that 6854-07-5 is playing an increasingly important role. we look forward to future research findings about 5-Nitro-2-oxo-3-pyridinecarboxylic Acid.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US5550122; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 6854-07-5

Application of 6854-07-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid. A new synthetic method of this compound is introduced below.

2-Hydroxy-5-nitronicotinic acid (2.7 mmol) in a mixture of /V,/V-di methyl formamidc (2.7 mmol) and thionyl chloride (5 ml) was heated at 80C for 1 h. The mixture was allowed to cool and concentrated in vacuo. To the resulting residue was added ice- water (20 ml) and with vigorous stirring a precipitate formed. The precipitate was filtered off and dried in a vacuum oven to give a white solid (68%). (0180) ESIMS: M-l: 201. (0181) 9.30 (1H, d, H-4), 8.83 (1H, d, H-6).

Reference:
Patent; BIONOMICS LIMITED; O’CONNOR, Sue; RATHJEN, Deborah; (55 pag.)WO2019/109150; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem