Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 685517-67-3, name is 2,6-Difluoro-3-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H2F2IN
n-Butyllithium (1.66mL, 4.15mmol, 2.5mol/L in hexane) was added dropwise to a solution of diisopropylamine (1.30mL, 4.15mmol) in THF (2mL) at -78C. After 25min 2,6-difluoro-3-iodopyridine (1.00g, 4.15mmol) in THF (5mL) was added dropwise into this mixture by cannula. After 12h at -78C, H2O (0.2mL, 11mmol) in THF (2mL) was added and the mixture was warmed to room temperature during 1h. The mixture was washed with 10% aqueous Na2SO3 (5mL) and extracted with ethyl acetate (3×50mL). The organic extracts were dried (MgSO4) and concentrated in vacuo. Crystallization from hexane afforded the product as colorless crystals (740mg, 74%). 1H NMR (400MHz, CDCl3): delta 7.22 (t, 2H,J=1.2). 13C NMR (100MHz, CDCl3): 161.1 (dd, J=250, 16, 2C), 115.6 (dd, J=24, 10, 2C), 110.3. 19F NMR (376MHz, CDCl3): delta -68.1. GC-MS m/z calcd. for C5H2F2IN [M+]: 241, found: 241. MP: 78-80C.
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Reference:
Article; Jin, Xin; Cramer, Jacob R.; Chen, Qi-Wei; Liang, Hai-Lin; Shang, Jian; Shao, Xiang; Chen, Wei; Xu, Guo-Qin; Gothelf, Kurt V.; Wu, Kai; Chinese Chemical Letters; vol. 28; 3; (2017); p. 525 – 530;,
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