Category: 69045-84-7

Adding a certain compound to certain chemical reactions, such as: 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H2Cl2F3N, blongs to pyridine-derivatives compound. HPLC of Formula: C6H2Cl2F3N

Powdered potassium hydroxide (9.35 g, 0.15 mol, 3 eq. ) is placed together with 70 ml dry DMSO in a 250 ml three-necked-bottom and under dry argon atmosphere the nitromethane (6.1 g, 0.1 mol, 2 eq) solved in 30 ml dry DMSO is added within 30 min slowly with mechanical stirring while cooling with an ice bath to maintain the temperature at 20 C. STIRRING of the reaction mixture at 20C is continued for additional 15 min. Then 2,3-dichloro-5-trifluoromethylpyridine (10.80 g, 0.05 mol, 1 eq. ) is added as one portion without endo-or exothermic reaction. The mixture is heated to 50 C, stirred for 3 h at this temperature and then allowed to cool to room temperature. The dark brown crude product is poured into 500 ml of water, acidified by addition of diluted hydrochloric acid and followed by three extractions with 50 ml ethyl acetate each. The combined organic layers are washed with three 30 ml portions of water and are subsequently dried over anhydrous sodium sulphate. After filtration the solvent is removed at 20C and under 150 mbar reduced pressure. Yield: 9.72 g 3-chloro-2-nitromethyl-5-trifluoromethylpyridine (73.9 % theoretical yield, 91. 4 % purity)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER CROPSCIENCE AG; WO2004/96772; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,3-Dichloro-5-(trifluoromethyl)pyridine

1.82 kg of 3-chloro-2-chloro-5-trifluoromethylpyridine was dissolved in 27.231 L of methanol,Then 1.0119 kg of triethylamine was added thereto,Heated to reflux for 4 hours, and cooled to 20 C to obtain a reaction solution,The resulting reaction solution was filtered to obtain a filter cake,The resulting filter cake was vacuum dried at 40 C for 1 hour to obtain an organic salt; The organic salt obtained in step (1), 0.27 kg of hydrocyanic acid was added to 2.7 L of dichloromethane and 1.35 L of water,The reaction was stirred at 0 C for 3 hours to obtain a mixed solution, and the resulting mixture was allowed to stand at room temperature to obtain an organic phase a;The obtained organic phase a is added to hydrochloric acid to adjust its pH to 2 and then the layers are separated to obtain an acid water layer and an organic layer,The resulting organic layer was washed with water to a pH of 6 to give the washed water and the organic phase b; The organic phase b obtained in step is distilled at atmospheric pressure to 60 C and then distilled under reduced pressure,Collection of vacuum 2mmHg,The temperature of the ketone temperature of 70 to 120 C is 1.77 kg of 3-chloro-2-cyano-5-trifluoromethylpyridine,Yield 85.7%.

With the rapid development of chemical substances, we look forward to future research findings about 69045-84-7.

Reference:
Patent; Shandong Province Union Pesticide Industry Co., Ltd; Tang, Jianfeng; Pan, Guangmin; Li, Wenhong; Su, Jingchi; Zhao, Baoxiu; Liu, Jie; (9 pag.)CN106349159; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2,3-Dichloro-5-(trifluoromethyl)pyridine

To a solution of ethyl 3- [2-hydroxy-4- (2- methoxyethoxy) phenylJbutanoate (5.50 g) in N, N- dimethylformamide (40 ml) was added sodium hydride (60% in oil, 932 mg) under ice-cooling, and the mixture was EPO subsequently stirred for 30 min. Then, 2, 3-dichloro-5- ‘ (trifluoromethyl) pyridine (3.0 ml) was added, and the mixture was stirred at room temperature for 2 hr. A saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried (MgSO4) , filtrated and concentrated. The obtained residue was subjected to silica gel column chromatography, and eluted with ethyl acetate-hexane (hexane alone to 35:65, v/v) to give ethyl 3- [2-{ [3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2- methoxyethoxy) phenylJbutanoate (7.80 g, yield: 87%) as a yellow oil.1H-NMR (300 MHz, CDCl3)S: 1.16 (3 H, t, J = 7.2 Hz), 1.22 (3 H, d, J = 7.0 Hz), 2.39 – 2.50 (1- H, m) , 2.56 – 2.70 (1 H, m) , 3.23 – 3.38 (1 H, m) , 3.43 (3 H, s) , 3.65 – 3.79 (2 H, m) , 3.96 – 4.19 (4 H, mj , 6.66 (1 H, d, J = 2.6 Hz), 6.85 (1 H, dd, J = 8.7, 2.6 Hz), 7.18 – 7.29 (1 H, m) , 7.98 (1 H, d, J = 2.1 Hz), 8.25 (1 H, d, J = 1.1 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/18314; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

General procedure: To a stirred solution of 4a (74.5 g, 410 mmol) in DMF (450 mL) was added NaH (60% dispersion in oil, 19.7 g, 491 mmol) at 0 C and the mixture was stirred at the temperature for 30 min. Then 2,3-dichloro-5-(trifluoromethyl)pyridine (60.0 mL, 433 mmol) was added to the mixture, which was allowed to warm to room temperature, and stirred at room temperature for 1 h and at 50 C for 1 h. The reaction was quenched with sat. NH4Cl on ice-bath and extracted with EtOAc and the combined organic layer was washed with water and brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residual solid was purified by silica gel chromatography (hexane-EtOAc, 9:1 to 2:1) to give a pale-yellow solid, which was recrystallized from EtOAc/hexane to give 5a (79.0 g, 53%) as white crystals.

The synthetic route of 69045-84-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rikimaru, Kentaro; Wakabayashi, Takeshi; Abe, Hidenori; Tawaraishi, Taisuke; Imoto, Hiroshi; Yonemori, Jinichi; Hirose, Hideki; Murase, Katsuhito; Matsuo, Takanori; Matsumoto, Mitsuharu; Nomura, Chisako; Tsuge, Hiroko; Arimura, Naoto; Kawakami, Kazutoshi; Sakamoto, Junichi; Funami, Miyuki; Mol, Clifford D.; Snell, Gyorgy P.; Bragstad, Kenneth A.; Sang, Bi-Ching; Dougan, Douglas R.; Tanaka, Toshimasa; Katayama, Nozomi; Horiguchi, Yoshiaki; Momose, Yu; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3332 – 3358;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,3-Dichloro-5-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. Safety of 2,3-Dichloro-5-(trifluoromethyl)pyridine

Example 6 : Preparation of 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1-phenylethanamine; Preparation of 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl-1-phenylethanone; To a suspension of 2.6 g (0.065 mol) of sodium hydride 60% in dimethoxyethane at room temperature is added 3.4 mL (0.029 mol) of acetophenone. After 45 min. , 5.55 mL ( 0.038 mol) of 2,3-dichloro-5-(trifluoromethyl)pyridine is added. After 25 min., the reaction mixture is poured over 100mL of hydrochloric acid 1N, extracted twice with 100mL of ethyl acetate. The organic phase is washed twice 100 mL of water, dried over magnesium sulfate, filtered and concentrated to provide 15g of crude material which is purified over a column of silica by using a mixture of heptane and ethyl acetate as eluent, to yield to 5.74 g of desired product 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1-phenylethanone (74%). RMN 1H delta (ppm) 8,73 ; (1H, s) ; 7,95 (1H, s) ; 7,45 (2H, m) ; 7,42 (2H, m) ; 4,75 (2H, s).

The synthetic route of 69045-84-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer CropScience S.A.; EP1548007; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H2Cl2F3N

The synthetic route of title compounds was outlined in Scheme (1). 2,3-Dichloro-5-(trifluoromethyl)pyridine (7.50mmol) was dissolved in ethanol (300 mL), then hydrazine hydrate (30 mmol) was dropwised under refluxing condition for 72 h to give 3-chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine 1. A CEM designed 10 mL pressure-rated vial was charged with 3-chloro-2-hydrazinyl-5-(trifluoromethyl) pyridine 1 (211 mg, 1 mmol) and aldehyde (1mmol), HOAc (0.1 mmol) in the solution of ethanol at the condition of microwave (15 min, 85C). All the other compounds are synthesized according the procedure.

With the rapid development of chemical substances, we look forward to future research findings about 69045-84-7.

Reference:
Article; Min, Li-Jing; Shi, Yan-Xia; Yang, Ming-Yan; Zhai, Zhi-Wen; Weng, Jian-Quan; Tan, Cheng-Xia; Liu, Xing-Hai; Li, Bao-Ju; Zhang, Yong-Gang; Letters in drug design and discovery; vol. 13; 4; (2016); p. 324 – 328;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H2Cl2F3N

General procedure: To a stirred solution of 4a (74.5 g, 410 mmol) in DMF (450 mL) was added NaH (60% dispersion in oil, 19.7 g, 491 mmol) at 0 C and the mixture was stirred at the temperature for 30 min. Then 2,3-dichloro-5-(trifluoromethyl)pyridine (60.0 mL, 433 mmol) was added to the mixture, which was allowed to warm to room temperature, and stirred at room temperature for 1 h and at 50 C for 1 h. The reaction was quenched with sat. NH4Cl on ice-bath and extracted with EtOAc and the combined organic layer was washed with water and brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residual solid was purified by silica gel chromatography (hexane-EtOAc, 9:1 to 2:1) to give a pale-yellow solid, which was recrystallized from EtOAc/hexane to give 5a (79.0 g, 53%) as white crystals.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Article; Rikimaru, Kentaro; Wakabayashi, Takeshi; Abe, Hidenori; Tawaraishi, Taisuke; Imoto, Hiroshi; Yonemori, Jinichi; Hirose, Hideki; Murase, Katsuhito; Matsuo, Takanori; Matsumoto, Mitsuharu; Nomura, Chisako; Tsuge, Hiroko; Arimura, Naoto; Kawakami, Kazutoshi; Sakamoto, Junichi; Funami, Miyuki; Mol, Clifford D.; Snell, Gyorgy P.; Bragstad, Kenneth A.; Sang, Bi-Ching; Dougan, Douglas R.; Tanaka, Toshimasa; Katayama, Nozomi; Horiguchi, Yoshiaki; Momose, Yu; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3332 – 3358;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 69045-84-7, blongs to pyridine-derivatives compound. Quality Control of 2,3-Dichloro-5-(trifluoromethyl)pyridine

EMBODIMENT 13: Preparation of ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate To a 500 mL three-necked flask equipped with a thermometer was added 200 g DMSO, 25 g potassium hydroxide and 24 g ethyl 2-cyanoacetate. 44 g 2,3-dichloro-5-(trifluoromethyl)pyridine was added while the reaction temperature was controlled within 50 C. After addition, the reaction was continued for 1 hour. After the reaction was complete, the solvent was removed. Water was added. The mixture was acidified with hydrochloric acid, filtered, washed with water, dried to produce 85 g ethyl ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate in 97% yield. 1H-NMR deltappm(CDCl3): 8.6(s, 1H), 6.27(s, 1H), 4.25(d, J=5.6 Hz, 2H), 3.40(br, 1H), 1.2 (t, J=5.6 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69045-84-7, its application will become more common.

Reference:
Patent; ZHEJIANG ZHUJI UNITED CHEMICALS CO., LTD; Su, Yehua; Shi, Jieping; Lu, Jianxin; Zhang, Tianhao; Yu, Xiaohua; Cai, Guoping; Chen, Bangchi; (7 pag.)US2017/369412; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 69045-84-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

A mixture of 2,3-dichloro-5-(trifluoromethyl)pyridine (10 mL, 72 mmol), hydrazine (10 mL, 0.32 mol), and ethanol (100 mL) was refluxed for 4 h, allowed to cool to rt, and then concentrated. The residue was partitioned between EtOAc (100 mL) and 0.43M NaOH (175 mL). The organic layer was dried, filtered, concentrated, and dried under vacuum to give 3-chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine as an off- white solid. 1H NMR (400 MHz, DMSO-d6): delta 8.53 (s, IH), 8.35 (d, IH), 7.91 (d, IH), 4.43 (s, 2H); LCMS: 212.3 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69045-84-7, its application will become more common.

Reference:
Patent; KALYPSYS, INC.; WO2009/117421; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

69045-84-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a suspension of NaH (0.043 g, 1.8 mmol, 4 equiv) in anhyd THF (2mL) at 0 C was added dropwise a solution of ethyl 6-methyl-7-oxo-2,3-dihydro-1H-pyrazolo[1,5-a]pyrimidin-1-ium-5-carboxylate 2,2,2-trifluoroacetate (38; 0.15 g, 0.44 mmol) in DMF (0.5 mL). After stirring the reaction mixture for 10 min, 2,3-dichloro-5-(trifluoromethyl)pyridine (0.115 g, 0.53 mmol, 1.2 equiv) was added dropwise, followed by the addition of THF (6 mL) and DMF (1.5 mL). The reaction mass was stirred for 1 h at r.t., then acidified with aq 2 N HCl, and extracted with EtOAc (3 ¡Á 50 mL). The combined organic layers were washed with brine, dried (Na2SO4), and concentrated under reduced pressure to obtain a crude mass. Trituration with Et2O and cooling to0 C afforded the desired product 39 as an off-white solid; yield: 0.135g (81%); mp 185-187 C.IR (KBr): 2922, 1734, 1672, 1554, 1323, 1136, 1051 cm-1.1H NMR (400 MHz, DMSO-d6): delta = 2.04 (s, 3 H), 3.20-3.44 (m, 8 H),4.16 (br t, J = 7.40 Hz, 2 H), 8.58-8.61 (m, 1 H), 8.65 (s, 1 H), 13.39-13.88 (m, 1 H).13C NMR (100 MHz, DMSO-d6): delta = 166.5, 157.7, 156.9, 156.2, 149.7,142.5, 136.5, 123.8, 123.0, 122.7, 121.4, 121.1, 119.9, 51.3, 30.3, 11.1. HRMS-ESI: m/z calcd for C14H10ClF3N4O3 (M + H): 375.0472; found:375.0465.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Article; Shirsale, Ashwini; Patil, Yogesh; Rawal, Girish K.; Pabba, Jagadish; Berthon, Guillaume; Sonawane, Ravindra P.; Sikervar, Vikas; Synthesis; vol. 50; 10; (2018); p. 2087 – 2093;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem