Category: 69045-84-7

69045-84-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

(1) The preparation of intermediate IV-2 [Show Image] 11.8 g (60 mmol) of piperazine hexahydrate was added to a 150 mL flask with 40 mL acetonitrile, heated to 40 C, 10.8 g (50 mmol) of 2,3-dichloro-5-(trifluoromethyl)pyridine was added dropwise to the solution in 15 min, then 9 mL triethylamine was added to the mixture and stirred at 40 C for 4 h. The reaction was monitored by TLC, upon completion, filtrated and washed by a little ethanol to obtain 12 g white solid (90.2% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Patent; Sinochem Corporation; Shenyang Research Institute of Chemical Industry Co., Ltd.; EP2281810; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

69045-84-7 ,Some common heterocyclic compound, 69045-84-7, molecular formula is C6H2Cl2F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

500mL glass bottle,Supporting serpentine condenser,54.0 g (0.25 mol) of 2,3-dichloro-5-trifluoromethylpyridine,DMAC 150g,Anhydrous KF 18.9 g (0.325 mol),4 g (0.018 mol) of benzyltriethylammonium chloride,The temperature of the oil bath was raised to 170 C,Time reaction 5h,After DMAC was recovered by distillation,2-Fluoro-3-chloro-5-trifluoromethylpyridine was collected under reduced pressure48.6g,Its content of 2-fluoro-3-chloro-5-trifluoromethylpyridine was 99.5%Yield 97%.

According to the analysis of related databases, 69045-84-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Inner Mongolia Jiaruimi Fine Chemical Co., Ltd.; Dong Yongxia; Xiang Bin; Li Jun; (5 pag.)CN107286087; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

69045-84-7, Adding a certain compound to certain chemical reactions, such as: 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 69045-84-7, blongs to pyridine-derivatives compound.

Step A Synthesis of 3-chloro-5-trifluoromethylpyrid-2-ylhydrazine To a solution of 60 mL of hydrazine monohydrate in 380 mL of ethanol was added 81 g (0.38 mole) of 2,3-dichloro-5-trifluoromethylpyridine during a period of 25 minutes. At the end of the addition the temperature had risen to 37 C. This mixture was heated to reflux and maintained at reflux for approximately 15 hours. The solvent was evaporated under reduced pressure, leaving a wet slurry that was immediately recrystallized from boiling ethanol/water (5:2). The mixture was cooled to 20 C. and then filtered. The filter cake was air-dried, yielding approximately 60 g of 3-chloro-5-trifluoromethylpyrid-2-ylhydrazine. The NMR spectrum was consistent with the assigned structure. This reaction was repeated to obtain additional material for subsequent reactions.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69045-84-7, its application will become more common.

Reference:
Patent; FMC Corporation; US5321002; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. 69045-84-7

Into a 500 mL autoclave, 51.2 g (0.2348 mol, 99%, 1.0 eq) of 2,3-dichloro-5-trifluoromethylpyridine and 160 mL of tetrahydrofuran were placed, and the autoclave was closed.Nitrogen was replaced three times at normal temperature, and 20.0 g (1.174 mol, 5.0 eq) of liquid ammonia was passed through the system, and the pressure in the system was about 0.6 MPa.The temperature was raised to 100 C to maintain the pressure reaction for 28 h.The system pressure was reduced from 1.6Mpa to 1.2Mpa, and the reaction of the raw material in the bottom tube sampling HPLC was complete. After the system is lowered to normal temperature, the pressure is released to normal pressure.The ammonia gas released is absorbed by tetrahydrofuran.The reaction solution was taken out, filtered, and rinsed with an appropriate amount of tetrahydrofuran, and the mother liquid was subjected to the next step of deamination.

Statistics shows that 69045-84-7 is playing an increasingly important role. we look forward to future research findings about 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Patent; Dalian Jiu Xin Fine Chemical Co., Ltd.; Inner Mongolia Jiaruimi Fine Chemical Co., Ltd.; Wang Rongliang; Wang Junchun; (10 pag.)CN110143916; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

69045-84-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

(R) -2- (4-hydroxyphenoxy) propionic acid (3 g),DMF (35 ml), slowly adding K2CO3 (4.55 g),Heating up to 70 ~ 80 ,Stir for 1h,Was added dropwise 2,3-dichloro-5-trifluoromethylpyridine (3.56 g)Keep at 70 ~ 80 for 8h,Stop the reaction,Naturally cooled to room temperature,The mixture was poured into ice water (200 mL)The pH was adjusted to 4 to 5 using dilute hydrochloric acid, extracted with ethyl acetate,Organic phase washed,dry,(R) -2- [4- (5-trifluoromethyl-3-chloropyridin-2-yloxy) phenoxy]Propionic acid brown liquid 5.03 g,Yield 84.4%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; China Three Gorges University; Liu Qixing; Zhou Haifeng; Lu Guoren; Peng Yuqi; (9 pag.)CN106632293; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem