Category: 6937-03-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6937-03-7, name is Methyl 2-aminoisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 6937-03-7

To a solution of Methyl 2-aminopyridine-4-carboxylate (10.0 g, 66 mmol, 1.0 equiv) in EtOH (150 ml) was added NaHCO3 (11.1 g, 132 mmol, 2.0 equiv) followed by chloroacetaldehyde (50% by weight in water, 13.0 ml, 99 mmol, 1.5 equiv). The mixture was refluxed for 2 h. Solvents were removed under reduced pressure and the crude mixture was partitioned between water and EtOAc. The resulting precipitate was washed with Et2O and recrystallised from MeOH/Et2O to afford 8.4 g of product. 1 H NMR (400 MHz, DMSO-d6): 8.66 (1 H, d), 8.16 (2H, s), 7.80 (1 H, s), 7.33 (1 H, d), 3.90 (3H, s). MS: [M+H]+ 177.

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Reference:
Patent; ASTEX THERAPEUTICS LIMITED; WO2009/47506; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6937-03-7, Methyl 2-aminoisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6937-03-7, blongs to pyridine-derivatives compound. SDS of cas: 6937-03-7

Compound 2E: methyl 2-((tert-butoxycarbonyl)amino)isonicotinate Methyl 2-aminopyridine-4-carboxylate (2 g, 13.14 mmol, 1.00 equiv) was dissolved in tert-butanol (20 mL) after which di-tert-butyl dicarbonate (4.02 g, 18.42 mmol, 1.40 equiv) was added. The reaction mixture was agitated at 60 C. overnight then the reaction was halted through the addition of an aqueous 1M NaHCO3 solution (50 mL). The solid was recovered by filtration, washed with 50 mL of EtOH then dried in vacuo to yield 2.5 g (75%) of compound 2E in the form of a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6937-03-7, its application will become more common.

Reference:
Patent; PIERRE FABRE MEDICAMENT; Goetsch, Liliane; Jouhanneaud, Alexandra; Perez, Michel; (95 pag.)US2017/112943; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6937-03-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6937-03-7, name is Methyl 2-aminoisonicotinate, molecular formula is C7H8N2O2, molecular weight is 152.1506, as common compound, the synthetic route is as follows.

Methyl 2-aminopyridine-4-carboxylate (2 g, 13.14 mmo 1, 1.00 equiv) wasdissolved in tert-butano 1 (20 mL) after which di-tert-butyl dicarbonate (4.02 g, 18.42mmol, 1.40 equiv) was added. The reaction mixture was agitated at 60C overnight then the reaction was halted through the addition of an aqueous 1M NaHCO3 solution (50 mL). The solid was recovered by filtration, washed with 50 mL of EtOH then dried in vacuo to yield 2.5 g (75 %) of compound 2E in the form of a white solid.

Statistics shows that 6937-03-7 is playing an increasingly important role. we look forward to future research findings about Methyl 2-aminoisonicotinate.

Reference:
Patent; PIERRE FABRE MEDICAMENT; PEREZ, Michel; RILATT, Ian; LAMOTHE, Marie; WO2014/174060; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6937-03-7 , The common heterocyclic compound, 6937-03-7, name is Methyl 2-aminoisonicotinate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add in the reaction tube0.2 mmol of methyl 2-aminopyridine-4-carboxylate,0.2 mmol of beta-nitrostyrene,lOmol% (0.02 mmol) Ce (OTf) 3, 1.5 ml toluene,After stirring at 120 C for 10 minutes, the heating and stirring were stopped, and the mixture was cooled to room temperature.The crude product is obtained by distillation under reduced pressure and purified by column chromatography.The target product was obtained, and the column chromatography eluent used was a mixture of petroleum ether and ethyl acetate (V:V = 5:1).The yield was 53%. The hydrogen spectrum and carbon spectrum of the product obtained in this example are shown in Fig. 3.The carbon spectrum of the obtained product is shown in Fig. 4.

The synthetic route of 6937-03-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gannan Normal University; Chen Zhengwang; Ye Min; Zhou Zhonggao; (17 pag.)CN108395399; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem