Category: 694-85-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 694-85-9, name is 1-Methylpyridin-2(1H)-one, molecular formula is C6H7NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C6H7NO

0.8mmol), compound A-3 (0.4mmol, 1 eq.), Three times with nitrogen was added 3mLpermuted dimethylsulfoxide (DMSO), injection of 100muL (0.80mmol) Compound B-1, wasstirred for 24 hours under blue light , compound C-3. The yield was 60percent.

With the rapid development of chemical substances, we look forward to future research findings about 694-85-9.

Reference:
Patent; Zunyi Medical College; He, Chunyang; Li, Xiaofei; (12 pag.)CN105669546; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 694-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 694-85-9, name is 1-Methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below.

To a stirred mixture of 1-METHYL-LH-PYRIDIN-2-ONE (33.47 g, 0.306 mol) and concentrated H2S04 (300 ML) at 100 °C was added concentrated HNO3 (120 mL) in portions. The reaction mixture was heated at this temperature overnight, and then poured into ice (1400 mL). The precipitate was filtered off and washed with water to give the title compound (Yield: 18.66 g, 30percent). LH NMR (400 MHZ, CDCl3) : 8 9.05 (d, 1H), 8.90 (d, 1H), 3.80 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,694-85-9, its application will become more common.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/69832; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 694-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 694-85-9, name is 1-Methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below.

i) [(l,6-dihydro-l-methyl-6-oxo-3-pyridinyl)sulfonyl]-, 1,1-dimethylethyl ester carbamic acid; hlorosulfonyl isocyanate (6mL) was added dropwise to a solution of 2-methyl-2-propanol(6.5mL) in DCM (75mL) at 0¡ãC. After 5min, l-methyl-2(lNo.)-pyridinone (9mL) was addeddropwise followed by A^Af-du’sopropylethylamine (14.5mL) also added dropwise. Thereaction mixture was then allowed to warm to room temperature over 18h. E^O (lOOmL) wasadded to the reaction mixture and the organic layer was separated. The aqueous was thenfurther extracted with DCM (2xlOOmL). The combined organic layers were dried (MgSO4),filtered and evaporated to give the subtitle compound as a pale yellow oil. Yield: 7gJH NMR: 5 (CDC13) 1.45 (s, 9H), 3.62 (s, 3H), 6.60-6.64 (m, 1H), 7.69-7.74 (m, 1H), 8.21-8.24 (m, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,694-85-9, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/24823; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 694-85-9, Adding some certain compound to certain chemical reactions, such as: 694-85-9, name is 1-Methylpyridin-2(1H)-one,molecular formula is C6H7NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 694-85-9.

At 0 ¡ã C, 1 mmol of N-methyl-2-pyridone was added to the reactor,1.2 mmol of compound of formula (II-1), 0.1 mmolDi (1,5-cyclooctadiene) rhodium tetrafluoroborate,0.1 mmol of ligand L, 8 ml of N, N-dimethylformamide and 2 ml of toluene,The reaction was stirred at 60 ¡ã C for 6 hours. After the reaction was completed, the reaction mixture was poured into water,And extracted with ethyl acetate, the organic phase was combined to remove the solvent,The resulting residue was subjected to silica gel column chromatography to give a compound of formula (III-1) in a yield of 89.5percent.

According to the analysis of related databases, 694-85-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhou Xiaofang; (5 pag.)CN106905230; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem