Category: 6945-67-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6945-67-1, name is 2-Bromo-4-nitropyridine. A new synthetic method of this compound is introduced below., Quality Control of 2-Bromo-4-nitropyridine

EXAMPLE 47 To a suspension of 2-bromo-4-nitropyridine (406 mg), 3-aminophenylboronic acid (403 mg) and tetrakis(triphenylphosphine)-palladium (116 mg) in 1,2-dimethoxyethane (10 ml) was added 2M aqueous solution of sodium carbonate (2.6 ml). The mixture was stirred at 80 C. for 7 hours under a nitrogen atmosphere, then cooled to room temperature and diluted with ethyl acetate. The organic layer was separated, washed with water and brine and dried over sodium sulfate. The solvent was evaporated under reduced pressure to give crude 3-(4-nitropyridin-2-yl)aniline. This compound was used for next step without purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6945-67-1, 2-Bromo-4-nitropyridine.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6521643; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6945-67-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6945-67-1, name is 2-Bromo-4-nitropyridine, molecular formula is C5H3BrN2O2, molecular weight is 202.99, as common compound, the synthetic route is as follows.

2-bromo-4-nitropyridine(1.00g, 4.93mmol),4,4-difluoropiperidine hydrochloride(1.16g, 7.39mmol) and cesium carbonate (4.82g, 14.78mmol) were dissolved in 20mL 1,4-Dioxane solution, heated to 100 reaction overnight, LC-MS detection.The reaction is completed, cooled to room temperature, filtered,The filtrate was concentrated and purified by column chromatography to obtain the title compound.

Statistics shows that 6945-67-1 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-4-nitropyridine.

Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Zhao Liwen; Wang Yazhou; Quan Xu; Liu Haixuan; Wang Xiaowei; Zhang Yan; Li Xue; Cao Chen; Guo Zhuang; Lv Kunzhi; Wang Hai; Zheng Guochuang; (126 pag.)CN111196804; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6945-67-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6945-67-1, name is 2-Bromo-4-nitropyridine, molecular formula is C5H3BrN2O2, molecular weight is 202.99, as common compound, the synthetic route is as follows.

2-bromo-4-nitropyridine(1.00g, 4.93mmol),4,4-difluoropiperidine hydrochloride(1.16g, 7.39mmol) and cesium carbonate (4.82g, 14.78mmol) were dissolved in 20mL 1,4-Dioxane solution, heated to 100 reaction overnight, LC-MS detection.The reaction is completed, cooled to room temperature, filtered,The filtrate was concentrated and purified by column chromatography to obtain the title compound.

Statistics shows that 6945-67-1 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-4-nitropyridine.

Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Zhao Liwen; Wang Yazhou; Quan Xu; Liu Haixuan; Wang Xiaowei; Zhang Yan; Li Xue; Cao Chen; Guo Zhuang; Lv Kunzhi; Wang Hai; Zheng Guochuang; (126 pag.)CN111196804; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 6945-67-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6945-67-1, name is 2-Bromo-4-nitropyridine, molecular formula is C5H3BrN2O2, molecular weight is 202.99, as common compound, the synthetic route is as follows.

Take 2-bromo-4-aminopyridine (8.651g, 50.0mmol), triethylamine (15.179g, 150mmol)And dichloromethane (50mL) placed in the reaction flask, weigh di-tert-butyl carbonate(16.369g, 75.0mmol), added to the above reaction flask at 0 , add,The reaction was stirred at 40C for 4h. After the reaction is complete, cool to room temperature,Add saturated sodium bicarbonate solution and dichloromethane to the reaction system, extract,Take the organic phase and dry with anhydrous sodium sulfate. After concentration under reduced pressure and purification by column chromatography, the title compound was obtained.

Statistics shows that 6945-67-1 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-4-nitropyridine.

Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Zhao Liwen; Wang Yazhou; Quan Xu; Liu Haixuan; Wang Xiaowei; Zhang Yan; Li Xue; Cao Chen; Guo Zhuang; Lv Kunzhi; Wang Hai; Zheng Guochuang; (126 pag.)CN111196804; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem