Adding a certain compound to certain chemical reactions, such as: 6945-68-2, 5-Bromo-3-nitropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H4BrN3O2, blongs to pyridine-derivatives compound. COA of Formula: C5H4BrN3O2
2,3-Diamino-3-bromopyridine (40) A mixture of 2-amino-5- bromo-3-nitropyridine (676 mg, 3.10 mmol), Tin(II) chloride dihydrate (3.58 g, 14.0 mmol), and EtOH (3 mL) was heated to boiling. The resulting solution was refluxed under N2 for 15 h, cooled to room temperature, and evaporated to dryness. To the residual solid was added H2 O (80 mL) and basified to pH 8 with 1N aq NaOH. The resulting mixture was extracted with EtOAc (3*50 mL). The extracts were combined, washed with brine (25 mL), dried (K2 CO3), and rota-evaporated to dryness. The residual solid was dried at 40 C. under vacuum, giving 565 mg (97%) of 40 as a pale yellow powder, mp 158-160 C. 1 H NMR (CDCl3 +DMSO-d6) delta3.816 (s, 2H), 4.525 (s, 2H), 6,838 (s, 1H), 7.446 (s, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6945-68-2, 5-Bromo-3-nitropyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.; US5620978; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem