Category: 6969-71-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6969-71-7, name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, the common compound, a new synthetic route is introduced below. name: [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one

Firstly, 1.35 g (10 mmol) of 1,2,4-triazolo[4,3-a]pyridin-3-(2H)-one (1), 2.5 cm3 (26 mmol) of1-bromo-3-chloropropane (2a), 322 mg (1 mmol) of TBAB, 8.28 g (60 mmol) of K2CO3, and 5 cm3 ofacetonitrile were placed in a conical flask. The reactions were carried out under microwave radiation(Samsung M182DN; 300 W) for 50 s. After this time, 2.3 g (10 mmol) of 1-(3-chlorophenyl)piperazine hydrochloride (4) and 5 cm3 of acetonitrile were added to the reaction mixture. Reactions were carriedout in the presence of microwave radiation for another 90 s. The progress of the reaction was monitoredby TLC (eluent chloroform-methanol 9:1). After the reaction, 50 cm3 of water was added and theresulting product was filtered o on a Buechner funnel. Yield (Samsung M182DN; 300 W) 31%, yield(CEM Discover SP reactor; 100 W) 71%.

The synthetic route of 6969-71-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jaskowska, Jolanta; Zar eba, Przemys?aw; Sliwa, Pawe?; Pindelska, Edyta; Sata?a, Grzegorz; Majka, Zbigniew; Molecules; vol. 24; 8; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6969-71-7 ,Some common heterocyclic compound, 6969-71-7, molecular formula is C6H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To the commercially available [112,4]triazolo[4,3-a]pyridin-3(2H)-one (27 mg, 0.20 mmol) and 18-crown-6 ether (55 mg, 0.21 mmol) in anhydrous 1 ,4-dioxan (1 ml.) was added a 1 M solution of potassium te/t-butoxide in tetrahydrofuran (210 mul_, 0.21 mmol) . The mixture was stirred at room temperature for 15 minutes and then 1 ml_ of a solution of 3,4-dichloro-N-[5-chloro-2-(chloromethyl)phenyl]benzenesulfonamide (655 mg, 1.7 mmol) in anhydrous 1 ,4-dioxane (17 mL) was added. The mixture was heated at 60 0C for 15 hours and then left to cool to room temperature. The solvent was removed under reduced pressure and the residue dissolved in dimethyl sulphoxide (0.5 mL) and then purified by mass directed autoprep to give 3,4-dichloro-N-{5-chloro-2-[(3- oxo[1 ,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl]phenyl}benzenesulfonamide as a white solid (6.6mg). HPLC Rt = 3.23 minutes; m/z [M+H]+ = 483. 1H NMR (d6-DMSO) delta 7.85 (m, 3H), 7.63 (d, 1 H), 7.28 (d, 1 H), 7.24 (t, 1 H), 7.17 (d, 1 H), 7.09 (d, 1 H), 6.99 (s, 1 H), 6.63 (t, 1 H)1 5.00 (S1 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6969-71-7, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMTED; WO2007/14054; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6969-71-7, [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H5N3O, blongs to pyridine-derivatives compound. Formula: C6H5N3O

At room temperature, [1,2,4] triazolo [4,3-a] pyridine-3 (2H) -one (500mg, 3.70mmol), 1,2-bromomethane (0.73mL, 8.50mmol) and DMF (10.0 mL), then NaH (125 mg) was added, and the reaction mixture was stirred at room temperature for 6 h.The reaction was quenched by adding water (30 mL), and then extracted with EA (30 mL × 2). The combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent. Petroleum ether (10 mL) was added to it, stirred for 30 min, filtered, the filtrate was collected, and dried in vacuo to give the title compound as a red solid (490 mg, 2.02 mmol, 54.70%).

The synthetic route of 6969-71-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Huang Jianzhou; Ren Qingyun; Xiong Jinfeng; Liu Yang; Yu Fangcai; Liu Weishun; Wang Yifeng; Zhang Yingjun; (104 pag.)CN110903284; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6969-71-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 6969-71-7, Name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, SMILES is O=C1NN=C2C=CC=CN21, belongs to pyridine-derivatives compound. In a article, author is Surov, Artem O., introduce new discover of the category.

Novel cocrystals of the potent 1,2,4-thiadiazole-based neuroprotector with carboxylic acids: virtual screening, crystal structures and solubility performance

Five new multicomponent solid forms of the biologically active 1,2,4-thiadiazole derivative (TDZH) with dicarboxylic and hydroxybenzoic acids have been discovered by combined virtual/experimental cocrystal screening. The interplay between the intrinsic hierarchy of the donor/acceptor groups in the TDZH/coformer molecules and the hydrogen bond pattern in the multicomponent crystals was rationalized using quantitative analysis of molecular electrostatic potential (MEP) surfaces along with periodic DFT computations. All the TDZH cocrystals are based on a carboxy-aminothiadiazole heterosynthon which is stabilized by a combination of enthalpic factors and the supramolecular chelating effect. According to the analysis of the non-covalent interaction energies, the mean energy value of this heterosynthon equals similar to 77 kJ mol(-1), which is comparable to the well-known carboxyl-amide and carboxyl-pyridine synthons in terms of the dissociation energy. The thermal stability of the multicomponent crystals was investigated by the DSC and TG methods. The pH-solubility behavior of the cocrystals was investigated at different pH values using eutectic concentrations of the components. Three out of five co-crystals were found to be more soluble than the parent TDZH at low pH values (approximate to 2.0). However, cocrystallization significantly alters the solubility-pH dependence of TDZH, increasing the compound solubility at neutral pH values.

Synthetic Route of 6969-71-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 6969-71-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 6969-71-7, Name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, formurla is C6H5N3O. In a document, author is Boden, Pit, introducing its new discovery. COA of Formula: C6H5N3O.

Investigation of Luminescent Triplet States in Tetranuclear Cu-I Complexes: Thermochromism and Structural Characterization

To develop new and flexible Cu-I containing luminescent substances, we extend our previous investigations on two metal-centered species to four metal-centered complexes. These complexes could be a basis for designing new organic light-emitting diode (OLED) relevant species. Both the synthesis and in-depth spectroscopic analysis, combined with high-level theoretical calculations are presented on a series of tetranuclear Cu-I complexes with a halide containing Cu4X4 core (X=iodide, bromide or chloride) and two 2-(diphenylphosphino)pyridine bridging ligands with a methyl group in para (4-Me) or ortho (6-Me) position of the pyridine ring. The structure of the electronic ground state is characterized by X-ray diffraction, NMR, and IR spectroscopy with the support of theoretical calculations. In contrast to the para system, the complexes with ortho-substituted bridging ligands show a remarkable and reversible temperature-dependent dual phosphorescence. Here, we combine for the first time the luminescence thermochromism with time-resolved FTIR spectroscopy. Thus, we receive experimental data on the structures of the two triplet states involved in the luminescence thermochromism. The transient IR spectra of the underlying triplet metal/halide-to-ligand charge transfer (M-3/XLCT) and cluster-centered ((CC)-C-3) states were obtained and interpreted by comparison with calculated vibrational spectra. The systematic and significant dependence of the bridging halides was analyzed.

If you are hungry for even more, make sure to check my other article about 6969-71-7, COA of Formula: C6H5N3O.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Shen, Wei, once mentioned the application of 6969-71-7, HPLC of Formula: C6H5N3O, Name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, molecular formula is C6H5N3O, molecular weight is 135.12, MDL number is MFCD00022632, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

A donor-acceptor ligand boosting the performance of FA(0.8)Cs(0.2)PbBr(3) nanocrystal light-emitting diodes

A donor-acceptor ligand, 3-amino-2-bromo-6-methoxypyridine (ABMeoPy), was introduced to passivate FA(0.8)Cs(0.2)PbBr(3) nanocrystals (NCs) by a post-processing method. The donor-acceptor interaction can greatly enhance the coordination bond of pyridine-Pb2+, and improve FA(0.8)Cs(0.2)PbBr(3) NC performance with 95.99% photoluminescence quantum yield (PLQY), 6-month stability in solution, and 26% trap density decrease. In the light of ABMeoPy passivation of FA(0.8)Cs(0.2)PbBr(3) NCs, the maximum luminance, the maximum current efficiency, and EQE of light-emitting diodes (LEDs) increased 69%, 110%, and 111%, respectively. The strategy of using D-A molecules to passivate perovskite NCs is quite simple and effective, which can be widely promoted in perovskite-based LEDs or solar cells.

If you are interested in 6969-71-7, you can contact me at any time and look forward to more communication. HPLC of Formula: C6H5N3O.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C6H5N3O, 6969-71-7, Name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, SMILES is O=C1NN=C2C=CC=CN21, belongs to pyridine-derivatives compound. In a document, author is Chavan, Subhash P., introduce the new discover.

Enantioselective Formal Total Synthesis of (-)-Quinagolide

The enantioselective formal total synthesis of (-)-quinagolide has been accomplished in a linear sequence of 8 purification steps from pyridine. The key steps are (a) organocatalyzed Diets-Alder reaction for fixing all three stereocenters on piperidine ring; (b) protecting group enabled deoxygenation of isoquinuclidine skeleton under Birch reduction condition; (c) Lewis acid (TiCl4) catalyzed intramolecular Friedel-Crafts cyclization of dicarboxylic acid; and (d) one-pot diastereoselective ketone reduction-intramolecular cyclization to form oxazolidinone which enables trans-geometry installation. During the course of the synthesis, an interesting reductive cleavage of the C-N bond in the electron-deficient isoquinuclidine skeleton under the Birch reduction conditions has been observed. This is the first synthetic effort to access the core skeleton of (-)-quinagolide.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6969-71-7 is helpful to your research. Formula: C6H5N3O.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

6969-71-7, Name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, molecular formula is C6H5N3O, SDS of cas: 6969-71-7, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Zhou, Wanli, once mentioned the new application about 6969-71-7.

Four new dual-functional electro-catalysts formed from small molybdenum clusters and Cu-pyridyl complexes

By changing N-heterocyclic ligands in the same Mo-7/Cu/N-ligand reaction systems, four new organic-inorganic hybrids based on isopolymolybdates, [Cu-2(tpy)(2)(beta -Mo8O26)(0.5)(gamma -Mo8O26)(0.5)]0.25H(2)O (1), [Cu-2(tpy)(2)(H2O)(2)(beta -Mo8O26)] (2), [Cu(bpy)(Mo3O10)]H2O (3), and [Cu(bpy)(H2O)(beta -Mo8O26)(0.5)](0.5) (4) (tpy = 2,2 ‘ :6 ‘ ,2 ‘ ‘ -terpyridine and bpy = 2,6-bis(pyrazol-1-yl) pyridine), were prepared using hydrothermal methods at different pH values. X-ray structural analysis shows that compound 1 has a 1D {-beta-[Mo8O26]-Cu-2-gamma-[Mo8O26]}(n) straight chain structure with mixed beta-[Mo8O26] and gamma-[Mo8O26] polyoxoanions; compound 2 possesses a 3D supramolecular structure based on [Cu(tpy)](2+) motifs and beta-[Mo8O26] clusters; and compound 3 has a 1D chain structure built from [Cu(bpy)](2+) and [Mo3O10](2-) units. In compound 4, [beta -Mo8O26] clusters are linked by [Cu(bpy)](2+) motifs to give rise to a 2D sheet structure including {(beta -Mo8O26)(4)Cu-4} 8-membered rings. Cyclic voltammograms of compounds 1-4 display discrepant dual-functional electro-catalytic activities toward the reduction of nitrite and the oxidation of ascorbic acid in acidic solution. Electrocatalytic tests indicate that the [Mo3O10](2-)-based organic-inorganic hybrid exhibits better electro-catalytic performances than [Mo8O26](4-)-type hybrids towards oxidation and reduction.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 6969-71-7 help many people in the next few years. SDS of cas: 6969-71-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 6969-71-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 6969-71-7, Name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, SMILES is O=C1NN=C2C=CC=CN21, belongs to pyridine-derivatives compound. In a article, author is Takao, Toshiro, introduce new discover of the category.

Diruthenium complexes having a partially hydrogenated bipyridine ligand: plausible mechanism for the dehydrogenative coupling of pyridines at a diruthenium site

The reactions of the diruthenium tetrahydrido complex, Cp*Ru(mu-H)(4)RuCp* (1) (Cp* = eta(5)-C5Me5), with pyridines were investigated in relation to the dehydrogenative coupling of 4-substituted pyridines. Complex 1 reacted with gamma-picoline to yield the bis(mu-pyridyl) complex, {Cp*Ru(mu-H)(mu-4-MeC5H3)}(2) (2a), with the elimination of dihydrogen. Complex 2a immediately reacted with the liberated dihydrogen to yield mu-eta(2)-dihydrobipyridine (dhbpy) complex 4avia C-C bond formation between the two pyridyl groups, in which one of the pyridine rings underwent partial hydrogenation. The X-ray structure of 4a shows that the dhbpy moiety adopts a mu-eta(2) coordination mode at the Ru-2 site. Complex 4a was reversibly converted to 5avia the elimination of dihydrogen in which the dhbpy moiety adopts a mu-eta(2):eta(2) mode. Although 5a was coordinatively saturated, 5a readily reacted with (BuNC)-Bu-t to yield 6a. This was owing to the ability of the dhbpy ligand changing its coordination mode between the mu-eta(2):eta(2) and mu-eta(2) modes. This also causes the dehydrogenation from the dhbpy ligand to yield mu-eta(2):eta(2)-bipyridine complex 7a at 140 degrees C. However, 7a was not shown to be an intermediate of the catalysis. The reaction of 1 with 1,10-phenanthroline afforded mu-eta(2)-phenanthroline complex 8 containing two hydrides, which can be a model compound for the bipyridine elimination from the Ru-2 site. Dynamic NMR studies suggested that 8 was isomerised to an unsaturated mu-N-heterocyclic carbene (NHC) complex. The unsaturated nature of the mu-NHC complex is likely responsible for the uptake of the third pyridine molecule to turn over the catalytic cycle.

Reference of 6969-71-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 6969-71-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 6969-71-7, Name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, SMILES is O=C1NN=C2C=CC=CN21, in an article , author is Gonzalez-Silva, Karen, once mentioned of 6969-71-7, Computed Properties of C6H5N3O.

Copper(ii) accelerated azide-alkyne cycloaddition reaction using mercaptopyridine-based triazole ligands

We report the preparation and full characterization of a series of mercapto pyridine-functionalized 1,2,3-triazoles and their use as ligands for the preparation of copper(ii) complexes. Complex 1 supported by a 2-mercaptopyridine functionalized triazole (A) and featuring a polymeric structure with the coordination of CuCl2 centers at both the triazole and pyridine fragments, displays a highly effcient click-type catalytic performance in alcoholic solvents without the need for an external reducing agent. Experimental results suggest that the copper(ii) species undergo reduction to catalytic copper(i) via alcohol oxidation during an induction period. The scope of the click reaction is broad including the high yielding synthesis of a series of mono, bis, and tris-triazoles, using microwave radiation under low catalyst loadings.

Interested yet? Read on for other articles about 6969-71-7, you can contact me at any time and look forward to more communication. Computed Properties of C6H5N3O.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem