Extracurricular laboratory: Synthetic route of N,N-Dimethylnicotinamide

Statistics shows that 6972-69-6 is playing an increasingly important role. we look forward to future research findings about N,N-Dimethylnicotinamide.

Related Products of 6972-69-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6972-69-6, name is N,N-Dimethylnicotinamide, molecular formula is C8H10N2O, molecular weight is 150.1778, as common compound, the synthetic route is as follows.

Step 2:[336] (0.05 g, 0.072 mmol, 1.0 eq) sodium iodide (0.038 g, 0.21 mmol, 3.0 eq) and nicotinamide [322] (0.011 g, 0.072 mmol, 1.0 eq) were added in ACN (3 ml). The reaction mixture was stirred at RT for 16 h in dark. Reaction progress was monitored by TLC. Solvent was removed under vacuum to get a crude product. The crude product obtained was triturated with diethyl ether (2 x 10 ml) to get the desired product [337], as black solid (0.044 g, 75%).

Statistics shows that 6972-69-6 is playing an increasingly important role. we look forward to future research findings about N,N-Dimethylnicotinamide.

Reference:
Patent; SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; WO2012/137225; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of N,N-Dimethylnicotinamide

According to the analysis of related databases, 6972-69-6, the application of this compound in the production field has become more and more popular.

Electric Literature of 6972-69-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6972-69-6, name is N,N-Dimethylnicotinamide. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of docetaxel [501](0.075 g, 0.093 mmol, 1.0 eq) in ACN (5 ml) was added Nal (0.055 g, 0.372 mmol, 4.0 eq) and Nu,Nu-dimethyl nicotinamide (0.023 g, 0.186 mmol, 2.0 eq) at RT. The reaction mixture was 60C over night. Solvent was removed under vacuum, solid residue taken in DCM, inorganic impurities filtered off, DCM removed under vacuum and the product triturated with ether, filtered and vacuum dried to get the product [502].

According to the analysis of related databases, 6972-69-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; WO2012/137225; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem