Category: 697300-73-5

Related Products of 697300-73-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.697300-73-5, name is 3-Bromo-5-iodopyridin-2-amine, molecular formula is C5H4BrIN2, molecular weight is 298.9071, as common compound, the synthetic route is as follows.

30 g of 3-bromo-5-iodopyridin-2-amine and 300 ml of ethanol were added1 g palladium / silica,First replace the air with nitrogen three times,And then replaced with hydrogen three times.Adjust the pressure of 0.05Mpa ~ 0.1Mpa,Temperature control at 20 ~ 30 , until the raw material reaction is complete.Filtration recovery catalyst,Concentrated part of the solvent,Add 300 ml of water,Then add 4.2 g of sodium hydroxide to neutralize,Cooled to 0 ~ 5 , filtered and dried.To give 16.8 g of 3-bromopyridin-2-amine,Yield 97%.

The chemical industry reduces the impact on the environment during synthesis 697300-73-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Zhejiang Jiuzhou Pharmaceutical Co., Ltd.; Zheng, Hui; Luo, Lijun; Qiu, Zhichao; (5 pag.)CN106432068; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 697300-73-5 , The common heterocyclic compound, 697300-73-5, name is 3-Bromo-5-iodopyridin-2-amine, molecular formula is C5H4BrIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-Bromo-5-iodopyridin-2-amine (7.50 g), 3,4-dimethoxyphenylboronic acid (4.79 g), tetrakis(triphenylphosphine)palladium (1.45 g) and potassium carbonate (10.4 g) were suspended in dioxane (100 ml) and water (10 ml), and the suspension was heated at 80 C. for 9.5 hours. After leaving to cool, a saturated aqueous ammonium chloride solution was added, and the organic layer was extracted with ethyl acetate and dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography [ethyl acetate] to give 7.36 g of the title compound as a solid. MS (ESI) m/z: 309, 311 (M+H)+.

The synthetic route of 697300-73-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ohki, Hitoshi; Ota, Masahiro; Takeuchi, Kosuke; Watanabe, Hideaki; Yamaguchi, Akitake; Shibata, Yoshihiro; Tominaga, Yuichi; Jimbo, Takeshi; Kobayashi, Keijiro; Kobayashi, Katsuhiro; Fukatsu, Daisuke; US2013/281428; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem