Category: 700-16-3

Bare Magnetite-Promoted Oxidative Hydroxylation of Arylboronic Acids and Subsequent Conversion into Phenolic Compounds was written by Cho, Hyun-A.;Lee, Yong-Ki;Kim, Seung-Hoi. And the article was included in Synlett in 2022.Recommanded Product: 700-16-3 The following contents are mentioned in the article:

The simple combination of readily available, recoverable, and recyclable magnetite (Fe₃O₄) nanoparticles and an environmentally friendly oxidant (H₂O₂) induced oxidative hydroxylation of arylboronic acids into their corresponding phenols ArOH [Ar = Ph, 2-MeC₆H₄, 4-MeC₆H₄, etc.] under mild conditions. Moreover, subsequent arylation or alkylation of intermediate with appropriate electrophiles was accomplished in a one-pot system, leading to the formation of halophenols and phenolic derivs ArOR [Ar = Ph, 3-MeC₆H₄, 4-MeC₆H₄, etc.; R = Bn, CH₂(4-FC₆H₄), allyl, etc]. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and Reactivity of a Low-Coordinate Iron(II) Hydride Complex: Applications in Catalytic Hydrodefluorination was written by Hein, Nicholas M.;Pick, Fraser S.;Fryzuk, Michael D.. And the article was included in Inorganic Chemistry in 2017.Application of 700-16-3 The following contents are mentioned in the article:

A low-coordinate iron hydride complex bearing an unsym. NpN (enamido-phosphinimine) ligand scaffold was synthesized and fully characterized. Insertion reactivity with azobenzene, 3-hexyne, and 1-azidoadamantane was explored, and the isolated products were analogous to previously reported 尾-diketiminate iron hydride insertion products. Surprisingly, the NpN iron hydride displays unprecedented reactivity toward hexafluorobenzene, affording an NpN iron fluoride complex and pentafluorobenzene as products. The NpN iron hydride is a precatalyst for catalytic hydrodefluorination of perfluorinated aromatics in the presence of silane. Kinetic studies indicated that the rate-determining step during catalysis involved silane. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reverse Arene Sandwich Structures Based upon 蟺-Hole路路路[M(II)] (d⁸ M = Pt, Pd) Interactions, where Positively Charged Metal Centers Play the Role of a Nucleophile was written by Rozhkov, Anton V.;Krykova, Mariya A.;Ivanov, Daniil M.;Novikov, Alexander S.;Sinelshchikova, Anna A.;Volostnykh, Marina V.;Konovalov, Mikhail A.;Grigoriev, Mikhail S.;Gorbunova, Yulia G.;Kukushkin, Vadim Yu.. And the article was included in Angewandte Chemie, International Edition in 2019.Formula: C5F5N The following contents are mentioned in the article:

[Pt(tpp)] (H₂tpp = tetraphenylporphyrin), [M(acac)₂] (M = Pd, Pt, Hacac = acetylacetone), and [Pd(ba)₂] (Hba = benzoylacetone) were co-crystallized with highly electron-deficient arene systems to form reverse arene sandwich structures built by 蟺-hole-[M(II)] (d⁸M = Pt, Pd) interactions. [Pt(tpp)]路2C₆F₆ is monomeric, whereas the diketonate 1:1 adducts form columnar infinity 1-dimensional-stack assembled by simultaneous action of both 蟺-hole-[M(II)] and C-F interactions. The reverse sandwiches are based on noncovalent interactions and calculated ESP distributions indicate that in 蟺-hole-[M(II)] contacts, [M(II)] plays the role of a nucleophile. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Formula: C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Theoretical Explanation of Reaction Site Selectivity in the Addition of a Phenoxy Group to Perfluoropyridine was written by Fuhrer, Timothy J.;Houck, Matthew;Corley, Cynthia A.;Iacono, Scott T.. And the article was included in Journal of Physical Chemistry A in 2019.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

Pentafluoropyridine, a potentially useful precursor in organofluorine methodol., undergoes selective substitution of a fluorine with a phenoxide at the site para to the nitrogen. Subsequent aryloxide substitutions can be accomplished at the ortho-positions with aryloxide groups containing various functional groups para to the phenoxide oxygen. During this phase of the reaction, “reverse reactions” involving substitutions of the original para substituent with a free fluoride or with another aryloxide moiety are observed with a frequency that depends on the functional group para to the oxygen on the aryloxide. Herein, we provide a theor. explanation of these observations through use of d. functional theory. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application In Synthesis of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine-functionalized linear and network step-growth fluoropolymers was written by Eismeier, Sydney;Peloquin, Andrew J.;Stewart, Kevin A.;Corley, Cynthia A.;Iacono, Scott T.. And the article was included in Journal of Fluorine Chemistry in 2020.Recommanded Product: 700-16-3 The following contents are mentioned in the article:

Step-growth polymers and networks were prepared with the nucleophilic aromatic substitution of perfluoropyridine with phenolic substrates. Linear AA-BB type, step-growth polymers were prepared to afford transparent, flexible films that exhibit excellent solution process ability in common organic solvents. Networks of similar type were optimized to produce highly densified crosslinks with moderate thermal stability and exceptional char yields. Herein, we highlight a new methodol. and their thermal properties for the preparation of linear and network polymers without the need to pre-install labile moieties producing materials of interest for high performance materials and potential applications thereof. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Au(I) Catalyzed HF Transfer: Tandem Alkyne Hydrofluorination and Perfluoroarene Functionalization was written by Mulryan, Daniel;Rodwell, Jack;Phillips, Nicholas A.;Crimmin, Mark R.. And the article was included in ACS Catalysis in 2022.Reference of 700-16-3 The following contents are mentioned in the article:

Herein, a catalytic protocol in which an equivalent of HF was generated from a perfluoroarene|nucleophile pair and transferred directly to an alkyne was reported. The reaction was catalyzed by [Au(IPr)NiPr₂] (IPr = N,N’-1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene). HF transfer generated two useful products in the form of functionalized fluoroarenes and fluoroalkenes. Mechanistic studies (rate laws, KIEs, d. functional theory (DFT) calculations, competition experiments) were consistent with the Au(I) catalyst facilitating a catalytic network involving both concerted S_NAr and hydrofluorination steps. The nature of the nucleophile impacted the turnover-limiting step. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Reference of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rational Tuning of Fluorobenzene Probes for Cysteine-Selective Protein Modification was written by Embaby, Ahmed M.;Schoffelen, Sanne;Kofoed, Christian;Meldal, Morten;Diness, Frederik. And the article was included in Angewandte Chemie, International Edition in 2018.Formula: C5F5N The following contents are mentioned in the article:

Fluorobenzene probes for protein profiling through selective cysteine labeling have been developed by rational reactivity tuning. Tuning was achieved by selecting an electron-withdrawing para substituent in combination with variation of the number of fluorine substituents. Optimized probes chemoselectively arylated cysteine residues in proteins under aqueous conditions. Probes linked to azide, biotin, or a fluorophore were applicable to labeling of eGFP and albumin. Selective inhibition of cysteine proteases was also demonstrated with the probes. Addnl., probes were tuned for site-selective labeling of cysteine residues and for activity-based protein profiling in cell lysates. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Formula: C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photoredox Polyfluoroarylation of Alkyl Halides via Halogen-Atom-Transfer was written by Niu, Ben;Sachidanandan, Krishnakumar;Blackburn, Bryan G.;Cooke, Maria Victoria;Laulhe, Sebastien. And the article was included in Organic Letters in 2022.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

The first polyfluoroarylation of unactivated alkyl halides RX (R = n-nonyl, cyclohexyl, adamantan-1-yl, 1-[(thiophen-2-yl)carbonyl]piperidin-4-yl, etc.; X = I, Br) e.g., I via halogen-atom-transfer process was described. This method converts primary, secondary, and tertiary alkyl halides into the resp. polyfluoroaryl compounds e.g., 3-(perfluorophenyl)butyl 4-methoxybenzoate in good yields in the presence of amide, carbamate, ester, aromatic and sulfonamide moieties including derivatives of complex bioactive mols. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after a halogen-atom-transfer. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP) was written by Brittain, William D. G.;Cobb, Steven L.. And the article was included in Organic Letters in 2021.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

The present work describes the application of pentafluoropyridine (PFP), a cheap com. available reagent, in the deoxyfluorination of carboxylic acids RC(O)OH (R = Et, adamantan-1-yl, Ph, 2-iodophenyl, etc.) to acyl fluorides RC(O)F. The acyl fluorides can be formed from a range of acids under mild conditions. The PFP that can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides was also demonstrated. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides RC(O)N(R¹)R² (R¹ = H, Me, Et; R² = Et, Ph, 3-nitrophenyl, etc.) in yields of 鈮?4%. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Polyfluoroarene-capped thiophene derivatives via fluoride-catalyzed nucleophilic aromatic substitution was written by Kikushima, Kotaro;Matsuki, Kana;Yoneda, Yuna;Menjo, Takayuki;Kaneko, Kosuke;Hanasaki, Tomonori;Dohi, Toshifumi. And the article was included in Heterocycles in 2021.Electric Literature of C5F5N The following contents are mentioned in the article:

Herein, a nucleophilic aromatic substitution reaction of polyfluoroarenes using silylthiophenes as nucleophiles was described for the synthesis of polyfluoroarene-capped thiophene derivatives, e.g., I in the presence of a catalytic amount of a fluoride salt. Various polyfluoroarene-capped thiophene derivatives were synthesized via double arylation under transition metal-free conditions. A fluoride ion activates a silylthiophene to trigger a nucleophilic aromatic substitution, subsequently affording the coupling product along with elimination of the fluoride ion, which serves as a promoter of the catalytic reaction. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Electric Literature of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 蟺-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 蟽 bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem