Category: 700-16-3

Identification of Reactive Intermediates Relevant to Dimethylgermylene Group Transfer Reactions of an Anthracene-Based Precursor was written by Geeson, Michael B.;Transue, Wesley J.;Cummins, Christopher C.. And the article was included in Organometallics in 2019.HPLC of Formula: 700-16-3 The following contents are mentioned in the article:

Dimethylgermylene ([Me₂Ge]) group transfer from the anthracene-based precursor dibenzo-7-dimethylgermanorbornadiene (Me₂GeA; A = C₁₄H₁₀, anthracene) was studied. Transfer of [Me₂Ge] from Me₂GeA to 2,3-dimethylbutadiene to give a dihydrogermole (2) was mediated by a Pt metallagermacycle (1), formed by oxidative addition of the Pt(0) species (Ph₃P)₂Pt(C₂H₄) into the strained Ge-C bond of Me₂GeA with concomitant loss of ethylene. Metallagermacycle 1 was characterized by multinuclear NMR spectroscopy, single-crystal x-ray diffraction, and elemental anal. The strained Ge-C bond of Me₂GeA was also found to undergo an addition reaction with pyridine, resulting in the [2.2.3]-bicyclic compound 3. Kinetics experiments on both the Pt- and pyridine-promoted systems implicate low-valent dimethylgermylene-containing species as reaction intermediates. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3HPLC of Formula: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Base-promoted relay reaction of heterocyclic ketene aminals with o-difluorobenzene derivatives for the highly site-selective synthesis of functionalized indoles was written by Luo, Da-Yun;Hu, Xing-Mei;Huang, Rong;Cui, Shi-Sheng;Yan, Sheng-Jiao. And the article was included in Tetrahedron in 2021.Recommanded Product: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

A novel method was developed for the construction of highly functionalized indole derivatives, including fluorinated indoles I (R = H, F, CN, NO₂; R¹ = H, F, NO₂, CN; R² = H, F, methoxycarbonyl; R³ = H, F CN; R⁴ = NO₂, benzoyl, (4-chlorophenyl)carbonyl, (thiophen-2-yl)carbonyl, etc.; Z = CH, N), via a site-selective, one-pot, two-step nucleophilic aromatic substitution reaction of o-difluorobenzene derivatives II with heterocyclic ketene aminals (HKAs) III promoted by two different bases (K₂CO₃ and Cs₂CO₃). A diverse library of indoles I was generated in good to excellent yields using a conventional base-mediated approach rather than metal catalysts. As a result, the highly functionalized indoles I were easily obtained in an environmentally friendly, rapid, and practical manner, and the products have potential biol. activity. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Transition-Metal-Free, Site-Selective C-F Arylation of Polyfluoroarenes via Electrophotocatalysis was written by Chen, Ya-Jing;Deng, Wen-Hao;Guo, Jia-Dong;Ci, Rui-Nan;Zhou, Chao;Chen, Bin;Li, Xu-Bing;Guo, Xiao-Ning;Liao, Rong-Zhen;Tung, Chen-Ho;Wu, Li-Zhu. And the article was included in Journal of the American Chemical Society in 2022.Name: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

Herein, an unprecedented transition-metal-free strategy was reported for site-selective CAr-F arylation of polyfluoroarenes with simple (het)arenes. By merging N,N-bis(2,6-diisopropylphenyl)perylene-3,4,9,10-bis(dicarboximide)-catalyzed electrophotocatalytic reduction and anodic nitroxyl radical oxidation in an electrophotocatalytic cell, various polyfluoroaroms. (2F-6F and 8F), especially inactive partially fluorinated aromatics, undergo sacrificial-reagents-free C-F bond arylation with high regioselectivity, and the yields are comparable to those for reported transition-metal catalysis. This atom- and step-economic protocol features a paired electrocatalysis with organic mediators in both cathodic and anodic processes. The broad substrate scope and good functional-group compatibility highlight the merits of this operationally simple strategy. Moreover, the easy gram-scale synthesis and late-stage functionalization collectively advocate for the practical value, which would promote the vigorous development of fluorine chem. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Name: 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 蟺-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 蟽 bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halogen Bonds of Halotetrafluoropyridines in Crystals and Co-crystals with Benzene and Pyridine was written by Schwabedissen, Jan;Trapp, Pia C.;Stammler, Hans-Georg;Neumann, Beate;Lamm, Jan-Hendrik;Vishnevskiy, Yury V.;Koerte, Leif A.;Mitzel, Norbert W.. And the article was included in Chemistry – A European Journal in 2019.Recommanded Product: 700-16-3 The following contents are mentioned in the article:

The structures of the three para-substituted halotetrafluoropyridines with chlorine, bromine, and iodine have been determined in the solid state (X-ray diffraction). The structures of these compounds and that of pentafluoropyridine were also determined in the gas phase (electron diffraction). Structures in the solid state of the bromine and iodine derivatives exhibit halogen bonding as a structure-determining motif. On the way to an investigation of halogen bond formation of halotetrafluoropyridines in the solid state with the stronger Lewis base pyridine, co-crystals of benzene adducts were investigated to gain an understanding of the influence of aryl-aryl interactions. These co-crystals showed halogen bonding only for the two heavier halotetrafluoropyridines. In the pyridine co-crystals halogen bonding was observed for all three para-halotetrafluoropyridines. The formation of homodimers and heterodimers with pyridine is also supported by quantum-chem. calculations of electron d. topologies and natural bond orbitals. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Defluorodearomatization: A Photocatalytic Birch-Like Reduction That Enables C-C Bond Formation and Provides Access to Unnatural Cannabinoids was written by Day, Jon I.;Grotjahn, Sascha;Senaweera, Sameera;Koenig, Burkhard;Weaver, Jimmie D. III. And the article was included in Journal of Organic Chemistry in 2021.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

Within the framework of discovery chem., polyfluorination remains a synthetic challenge despite its ability to provide useful characteristics, such as a reduction in the number of hydrogen bond donors and metabolic stability. Coupling a reversal of this methodol. with photocatalysis has been demonstrated to allow the rapid synthesis of previously difficult or impossible targets by starting with fluorines everywhere and selectively removing or functionalizing them. Herein, we demonstrate a novel method to synthesize 1,4-cyclohexadienes through a dearomative photocatalytic C-C coupling reaction. This allows for access to materials that are orthogonal to the selectivity of the Birch reaction and are more functional-group-tolerant. The reaction also allows the efficient synthesis of polyfluorinated cannabinoids. While the yields are modest, the access to the new chem. space provided by the reaction is unprecedented by any means. The trifluorinated analog of THC, 1-deoxy-1,2,4-trifluoro-THC, is synthesized, demonstrating the importance of discovery chem. and the ability to explore otherwise unknown structure-activity relationships. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 蟺-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 蟽 bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

How Aromatic Fluorination Exchanges the Interaction Role of Pyridine with Carbonyl Compounds: The Formaldehyde Adduct was written by Lopez, Juan Carlos;Macario, Alberto;Maris, Assimo;Alkorta, Ibon;Blanco, Susana. And the article was included in Chemistry – A European Journal in 2021.Synthetic Route of C5F5N The following contents are mentioned in the article:

The rotational spectrum of the weakly bound complex pentafluoropyridine路路路formaldehyde has been investigated using Fourier transform microwave spectroscopy. From the anal. of the rotational parameters of the parent species and of the ¹³C and ¹⁵N isotopologs, the structural arrangement of the adduct has been unambiguously established. The full ring fluorination of pyridine has a dramatic effect on its binding properties: It alters the electron d. distribution at the 蟺-cloud of pyridine creating a 蟺-hole and changing its electron donor-acceptor capabilities. In the complex, formaldehyde lies above the aromatic ring with one of the oxygen lone pairs, as conventionally envisaged, pointing toward its center. This lone pair路路路蟺-hole interaction, reinforced by a weak C-H路路路N interaction, indicates an exchange of the electron-acceptor roles of both mols. when compared to the pyridine路路路formaldehyde adduct. Tunnelling doublets due to the internal rotation of formaldehyde have also been observed and analyzed leading to a discussion on the competition between lone pair路路路蟺-hole and 蟺路路路蟺 stacking interactions. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Controllable deuteration of halogenated compounds by photocatalytic D₂O splitting was written by Liu, Cuibo;Chen, Zhongxin;Su, Chenliang;Zhao, Xiaoxu;Gao, Qiang;Ning, Guo-Hong;Zhu, Hai;Tang, Wei;Leng, Kai;Fu, Wei;Tian, Bingbing;Peng, Xinwen;Li, Jing;Xu, Qing-Hua;Zhou, Wu;Loh, Kian Ping. And the article was included in Nature Communications in 2018.Name: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

Deuterium labeling is of great value in organic synthesis and the pharmaceutical industry. However, the state-of-the-art C-H/C-D exchange using noble metal catalysts or strong bases/acids suffers from poor functional group tolerances, poor selectivity and lack of scope for generating mol. complexity. Herein, the deuteration of halides using heavy water as the deuteration reagent and porous CdSe nanosheets as the catalyst was demonstrated. The deuteration mechanism involves the generation of highly active carbon and deuterium radicals via photoinduced electron transfer from CdSe to the substrates, followed by tandem radicals coupling process, which is mechanistically distinct from the traditional methods involving deuterium cations or anions. This deuteration strategy showed better selectivity and functional group tolerances than current C-H/C-D exchange methods. Extending the synthetic scope, deuterated boronic acids, halides, alkynes, and aldehydes can be used as synthons in Suzuki coupling, Click reaction, C-H bond insertion reaction etc. for the synthesis of complex deuterated mols. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Name: 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Characterizing the lone pair路路路蟺-hole interaction in complexes of ammonia with perfluorinated arenes was written by Li, Weixing;Usabiaga, Imanol;Calabrese, Camilla;Evangelisti, Luca;Maris, Assimo;Favero, Laura B.;Melandri, Sonia. And the article was included in Physical Chemistry Chemical Physics in 2021.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

When hydrogen is completely replaced by fluorine, arenes become prone to forming a lone pair路路路蟺-hole non-covalent bond with ligands presenting electron rich regions. Such a species is ammonia, which confirms this behavior engaging its lone pair as the electron donor counterpart in the 1 : 1 adducts with hexafluorobenzene and pentafluoropyridine. In this work, the geometrical parameters of the interaction have been unambiguously identified through the detection, by means of Fourier transform microwave spectroscopy, of the rotational spectra of both normal species and their ¹⁵NH₃ isotopologues. An accurate anal. of the exptl. data, including internal dynamics effects, endorsed by quantum chem. calculations, both with topol. anal. and energy decomposition method, extended to the hydrogenated arenes and their water complexes, proved the ability of ammonia to create a stronger and more flexible lone pair路路路蟺-hole interaction than water. Interestingly, the higher binding energies of the ammonia lone pair路路路蟺-hole interactions correspond to larger intermol. distances. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of the pendent groups on biobased polymers, obtained from click chemistry suitable, for the adsorption of organic pollutants from water was written by Brirmi, Nour El Houda;Chabbah, Taha;Chatti, Saber;Schiets, Frederic;Casabianca, Herve;Marestin, Catherine;Mercier, Regis;Weidner, Steffen M.;Errachid, Abdelhamid;Jaffrezic-Renault, Nicole;Romdhane, Hatem Ben. And the article was included in Polymers for Advanced Technologies in 2022.SDS of cas: 700-16-3 The following contents are mentioned in the article:

In this work, four triazole-based poly(ether-pyridine)s polymers were synthesized and used as an adsorbent for the removal of phenolic compounds from aqueous solutions For this purpose, new fluoromonomers containing 1,2,3-triazole units were prepared by the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction and then used for the elaboration of novel poly(ether-pyridine-triazole)s (PEPTs) by direct polycondensation with isosorbide and bisphenol A. Chem. structure of fluorinated pyridinic monomers as well as resulting polymers was confirmed by ¹H and ¹⁹F NMR spectroscopic methods. The thermal behavior of the obtained PEPTs was characterized using differential scanning calorimetry and thermogravimetric anal. Results of sorption showed that polymers can be effectively used as a sorbent for the removal of polar organic pollutants. The isosorbide-based poly(ether-pyridine-triazole) which contains hydrophilic hydroxyl groups as pendants chains (P4) exhibited the highest sorption efficiencies (78%-100% after 1 h). In order to explain the results an adsorption mechanism mainly based on 蟺-蟺 interactions and hydrogen bonding with the pendent groups is proposed. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3SDS of cas: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kinetics of the Thermal Decomposition of 2,4,6-Triazido-3,5-Difluoropyridine was written by Nedel’ko, V. V.;Chukanov, N. V.;Korsunskiy, B. L.;Larikova, T. S.;Chapyshev, S. V.;Zakharov, V. V.. And the article was included in Russian Journal of Physical Chemistry B in 2018.COA of Formula: C5F5N The following contents are mentioned in the article:

The kinetics and products of the thermal decomposition of 2,4,6-triazido-3,5-difluoropyridine in melt at temperatures of 120-160掳 have been studied using pressure measurements, DTA, and IR spectroscopy. The reaction occurs in two macroscopic steps, each described by a first-order kinetic equation. In the first, the activation energy and the common logarithm of the pre-exponential factor are 35.6 卤 1.2 kcal/mol and 15.1 卤 0.6 s^-1, resp. For the studied compound (and certain other heterocyclic azides, such as 2,4,6-triazido-1,3,5-triazine and 2,4,6-triazidopyrimidine), the pre-exponential factor is anomalously high. This is due to the fact that the 2,4,6-triazido-3,5-difluoropyridine mol. contains no hydrogen atoms. For such azides, the usual decomposition mechanism (cleavage of the azide group with subsequent attack of nitrene on a hydrogen atom of a neighboring mol.) is impossible, which favors the stability of the formed nitrene. In this case, the reaction occurs through a complex chain polymerization mechanism, which leads to the formation of specific condensed products: packs of planar polyconjugate carbon-nitrogen networks with a porphyrin-like structure. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3COA of Formula: C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem