Synthetic Route of 701-44-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 701-44-0, name is 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide. A new synthetic method of this compound is introduced below.
To a stirred solution of l-methyl-6-oxo-l,6-dihydropyridine-3-carboxamide (460 mg, 3.02 mmol) in 20 mL of CH2C12 was added TEA (0.548 mL, 3.93 mmol) at 0 C. The reaction mixture was stirred for 10 min and then triflic anhydride was added (1.0 M in CH2C12, 3.33 mL, 3.33 mmol). Removed ice bath and stirred at ambient temperature for 3 h. The reaction was quenched with water and saturated aqueous sodium chloride. The aqueous layer was extracted with CH2C12 (3x’s). The combined organic layers were then dried over sodium sulfate and concentrated in vacuo. The crude product was purified by silica gel chromatography, eluting with a gradient of hexanes: ethyl acetate (95:5 to 15:85), to give the title compound. MS: m/z = 135.0 [M+l]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,701-44-0, 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CROWLEY, Brendan; FRALEY, Mark; POTTEIGER, Craig; LIM, John; SHERER, Ed; YU, Younong; MITCHELL, Helen; BIFTU, Tesfaye; NAIR, Anilkumar; WANG, Cheng; YANG, De-Yi; ZHU, Cheng; KAR, Nam Fung; HUANG, Xianhai; CHEN, Lei; ZHOU, Wei; PARK, Min, K.; CAI, Jiaqiang; WO2015/161014; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem