Category: 70165-31-0

Synthetic Route of 70165-31-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 70165-31-0 as follows.

A tetrahydrofuran solution of a boranetetrahydrofuran complex (1 M; 50 mL) was added to a solution of 6-cyanonicotinic acid (0.85 g) in tetrahydrofuran (20 mL) under ice-water cooling, followed by stirring at room temperature overnight. Methanol was added to the mixture under ice-water cooling, and then a 10% hydrogen chloride in methanol was added to the mixture, followed by stirring for 1 hour at 40C at room temperature. The solvent was removed under reduced pressure, and the resultant residue was purified by means of silica gel column chromatography [Chromatorex NH] (eluent; methanol : methylene chloride=1 : 1) to prepare the titled compound (1.54 g, Example Intermediate 36-1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,70165-31-0, its application will become more common.

Reference:
Patent; MOCHIDA PHARMACEUTICAL CO., LTD.; EP1445250; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 70165-31-0, name is 6-Cyanonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 70165-31-0

EXAMPLE 1 5-Carboxy-2-(4,5-dihydro-2-thiazolyl)-pyridine Sodium (11 mmol) is added to a flask containing 75 ml of ethanol. As soon as the sodium has dissolved, 10 mmol of 5-carboxy-2-cyanopyridine and 11 mmol of 2-amino-ethanethiol are added and the solution is refluxed for 24 h. The solution is then diluted with 25 ml of water, made acidic (pH=5) with 2N HCl and evaporated. The residue is dissolved in 100 ml of hot chloroform, the salts are filtered off and the filtrate on cooling gives crystals of the title compound, m.p. 234-235 C. The starting material is prepared as follows:

With the rapid development of chemical substances, we look forward to future research findings about 70165-31-0.

Reference:
Patent; Zyma SA; US4904675; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem