Category: 70201-43-3

Reference of 70201-43-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.70201-43-3, name is 3-Bromoisonicotinaldehyde, molecular formula is C6H4BrNO, molecular weight is 186.0061, as common compound, the synthetic route is as follows.

To a solution of 5-methoxy-1-indanone (0.32 mmol) and 3-bromo-4-pyridinecarboxaldehyde (0.36 g, 2 mmol) in toluene (30 mL) was added p-toluenesulfonic acid (0.45 g, 2.4 mmol). After heated atreflux using a Dean-Stark for 4h, the mixture was cooled to room temperature and the solvent was removed in vacuum, then 5% sodium bicarbonate solution was added until pH 8. After extraction with dichloromethane (4x), the organic layer was dried over magnesium sulfate and concentrated to dryness. The residue was taken up with EtOAc and the solid was filtered, rinsed with EtOAc to afford the title compound 91 as a yellow solid (Yield 330 mg, 50%).1fl NMR (300 MHz, CDC13, 6): 3.91 (br s, 5H), 6.96-7.00 (m, 2H), 7.49 (d, 1H, J 5,1 Hz), 7.74(t, 1H, J= 2.4 Hz), 7.87 (d, 1H, J= 8.4 Hz), 8.58 (d, 1H, J= 5.1 Hz), 8.82 (s, 1H).?3C NMR (75 MHz, CDCI3, 6): 31.7, 55.8, 109.8, 115.8, 123,5, 126.7, 128.2, 131.1, 141.2, 143.1, 148.3, 152.3, 153.0, 165.8, 191.3.

The chemical industry reduces the impact on the environment during synthesis 70201-43-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; INSA (INSTITUT NATIONAL DES SCIENCES APPLIQUEES) DE ROUEN; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE ROUEN; VFP THERAPIES; MARSAIS, Francis; LEVACHER, Vincent; PAPAMICAEL, Cyril; BOHN, Pierre; PEAUGER, Ludovic; GEMBUS, Vincent; LE FUR, Nicolas; DUMARTIN-LEPINE, Marie-Laurence; WO2014/114742; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 70201-43-3, 3-Bromoisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H4BrNO, blongs to pyridine-derivatives compound. Formula: C6H4BrNO

[0068] To a solution of 3-bromo-4-pyridinecarboxaldehyde 3 (3.0 g, 16.2 mmol) in absolute methanol (40 mL) was added NaBH4 (0.736 g 19.5 mmol) at 0C. The mixture was stirred at 0C for 2 hours under nitrogen. The solvent was then removed under vacuum. Water and ethyl acetate were added and the organic layer was washed with water, dried over Na2SO4 and evaporated under vacuum to afford the compound 4 (3.021 g, 100%) as a white powder. 1H NMR (CDCl3, 300 MHz, 298 K, delta ppm): 8.61 (s, 1 H), 8.51 (d, 1H, J = 4.8 Hz), 7.55 (d, 1H, J = 4.8 Hz), 4.76 (s, 2 H), 2.89 (s, 1H). 13C NMR (CDCl3, 75.5 MHz, 298 K, delta ppm): 151.14, 149.45, 148.54, 122.47, 119.90, 63.47. GC/MS (m/z): 188 IR (KBr, v, cm-1): 3152, 2894, 2829, 1593, 1447, 1401, 1333, 1223, 1170, 1070, 1024, 834, 705, 599

The synthetic route of 70201-43-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSA (Institut National des Sciences Appliquees) de Rouen; Centre National de la Recherche Scientifique (CNRS); Universite de Rouen; VFP Therapies; Marsais, Francis; Levacher, Vincent; Papamicael, Cyril; Bohn, Pierre; Peauger, Ludovic; Gembus, Vincent; Le Fur, Nicolas; Dumartin-Lepine, Marie-Laurence; EP2759536; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 70201-43-3 ,Some common heterocyclic compound, 70201-43-3, molecular formula is C6H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a 50 mL round-bottomed flask charged with pentahydratedbismuth nitrate (0.032 g, 0.065 mmol) in ethanol(20 mL) were added thiobarbituric acid (0.144 g, 1.0 mmol) and aromatic aldehydes (1.0 mmol). The reaction mixturewas stirred for 10-20 min at 80 C, when thin layer chromatographyanalyzes revealed it was completed. Aftercompletion the precipitated product was separated by filtration,dried, and recrystallized from ethanol. Full physicaland spectroscopic data and yields for all compounds arepresented in the supporting information (SI).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,70201-43-3, its application will become more common.

Reference:
Article; Shabeer, Muhammad; Barbosa, Luiz C. A.; Karak, Milandip; Coelho, Amanda C. S.; Takahashi, Jacqueline A.; Medicinal Chemistry Research; vol. 27; 4; (2018); p. 1043 – 1049;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70201-43-3, name is 3-Bromoisonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4BrNO

Zn powder (10 g, excess) was added to a solution of 10 (4.8 g, 25.8 mmol) and allylbromide (3.9 mL, 50 mmol) in DMF under N2 at RT. The resulting mixture was stirred at RT for 1 hr, DMF was then removed in vacuo and the residue was partitioned into saturated aqueous Na2CO3 and ethyl acetate (150 mL). The aqueous layer was further extracted with ethyl acetate and the combined organic extraction was dried over Na2SO4. After concentration, the residue was purified by chromatography (SiO2, hexane/ethyl acetate, 5:1) to afford 11 (5.35 g, 91 %) as a light yellowish oil. 1H NMR (300 MHz, CDCl3), delta 8.58 (s, 1H), 8.44 (d, J = 5.4 Hz, 1H), 7.50 (d, J = 5.4 Hz, 1H), 5.76-5.92 (m, 1H), 5.12-5.22 (m, 2H), 4.98-5.04 (m, 1H), 2.82-3.00 (br, 1H), 2.60-2.68 (m, 1H), 2.25-2.34 (m, 1H). 13C NMR (75 MHz, CDCl3), delta 152.3, 151.9, 488.3, 132.8, 122.5, 120.1, 118.8, 70.5, 40.9. HRMS: m/e 226.9937, 228.9923 (Calcd for C9H10NOBr, 226.9942; C9H10NO81Br, 228.9919).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 70201-43-3, 3-Bromoisonicotinaldehyde.

Reference:
Article; Zhang, Zhenfa; Dwoskin, Linda P.; Crooks, Peter A.; Tetrahedron Letters; vol. 52; 21; (2011); p. 2667 – 2669;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem