Category: 70298-88-3

Application of 70298-88-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 70298-88-3, name is 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, molecular formula is C10H14N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-Phenyl-2-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidm-1-yl]methyl}phenyl)-1,7-naphthyridin-8(7H)-one (5-6)N-Formyl-N-(4-formylpyridin-3-yl’)-2,2-dimethylpropanainide (5-1)A solution of 2,2-dimethyl-N-(3-pyridinyl)propanamide (3.56 gm, 20 mmol) (prepared as described in J.Org.Chem. 48, 3401 (1983)) in anhydrous tetrahydrofuran (40 mL) was cooled to -700C and a solution of 2.5 M n-butyl lithium/hexane (20 mL, 50 mmol) was added dropwise maintaining the temperature at -700C. This reaction was slowly warmed to -5C giving a copious precipitate. This mixture was cooled to -700C and dry dimethyl formamide (4.64 mL, 60 mmol) was added. The reaction was allowed to warm to room temperature giving a clear yellow solution. This reaction was poured into 8 N aqueous HCl (16 mL) and ice. After stirring for 10 minutes the pEta of the solution was adjusted to 7 and extracted with diethyl ether. The organic layer was dried (Na2SO_j.), filtered and the solvent evaporated. The residue was purified by column chromatography eluting with 30-100% ethyl acetate/hexane. The appropriate fractions were combined and the solvent removed in vacuo to give the title compound as a solid. 1Eta-NMR (500 MHz, CDCl3): delta 10.92 (IH, br s), 10.15 (IH, s),10.05 (IH, s), 8.62 (2H, d, J=4.9Hz), 7.56 (IH, d, J=4.9Hz),), 1.39 (9H, s). m/e (m+1): 235.3.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 70298-88-3, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide.

Reference:
Patent; MERCK & CO., INC.; WO2006/65601; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 70298-88-3, name is 2,2-Dimehtyl-N-pyridin-3-yl-propionamide. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

In the three bottle,3-Pivalamidopyridine (20.0 g, 112.2 mmol) was dissolved in anhydrous tetrahydrofuran (200 mL).In nitrogen protection, the temperature drops to -78 C,N-butyllithium (17.8 g, 280.5 mmol) was added dropwise and the solution was dropped.Slowly warming to 0C for 3 hours,Then cool down to -78 C,N-methyl-N-methoxyacetamide (17.4 g, 168.3 mmol) was added dropwise.After completion of the dropwise addition, the reaction was slowly warmed to room temperature for 10 h.After the reaction was completed, the reaction was quenched with 1N hydrochloric acid, extracted with ethyl acetate (100 mL×3), and the organic phase was collected and washed with saturated brine (100 mL×1).The solvent was evaporated under reduced pressure to give crude N-(4-ethanhydrin-3-yl)trimethylacetamide.The crude product was applied on a silica gel column (mobile phase: PE_EA=5:1) to obtain 11.2 g of a pure product with a yield of 45.4%.

With the rapid development of chemical substances, we look forward to future research findings about 70298-88-3.

Reference:
Patent; Guizhou University; Liu Li; Huang Zhuyan; Yue Yi; (8 pag.)CN107382839; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 70298-88-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 70298-88-3 as follows.

To a solution of 2.67 g (15.0 mmol, 1 eq.) of pivalamide IV and 6.8 mL (45.0 mmol, 3 eq.) of TMEDA in 120 mL of dry diethylether, cooled to -78C, were added 18.0 mL (45.0 mmol, 3 eq., 2.5 M in hexane) of BuLi. After 15 minutes, the solution was brought back to -24C and stirred 2 hours. Then, the mixture was cooled down to – 78C before addition of 4.0 mL (33.0 mmol, 2.2 eq) of p-anisaldehyde in 60 mL of THF. The reaction was brought back to 0C and stirred 2 hours before being stirred at room temperature over night. Then, 120 mL of water were added. The aqueous layer was extracted with 2 x 80 mL of dichloromethane. The organic phase was dried, filtered and concentrated. The crude mixture was purified over silicagel. The obtained white solid (estimation 9 mmol of XII) was dissolved in 90 mL of DCM. Then, 7.74 g (89.0 mmol, 10 eq.) of activated Mn02 were added and the reaction was refluxed 20 hours. The reaction was brought back to room temperature and 7.74 g (89.0 mmol, 10 eq.) of activated Mn02 were added again. After 20 hours to reflux, the mixture was filtered on celite and the solvent was evaporated. The crude mixture was dissolved in 180 mL of 3 M aqueous HCI were added and refluxed 16 hours. The reaction was cooled down to 0C and 50 mL of aqueous ammonia were added. The aqueous layer was extracted with 3 x 90 mL of DCM. The organic phase was dried, filtered and concentrated. Purification over silica gel afforded 1.65 g (7.2 mmol, 48%) of XIII as a yellow solid. The yield varied from 38% to 48%. Rf=0.15 (PE/EtOAc 1 :2). 1H NMR (300 MHz): delta = 8.26 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.72 (m, 2 H), 7.22 (m, 1 H), 6.96 (d, J = 5.1 Hz, 2 H), 5.58 (s, 2 H), 3.88 (s, 3 H) ppm. 13C NMR (75 MHz): delta = 196.5, 163.4, 144.0, 141.1 , 137.1 , 132.2, 130.6, 124.7, 123.4, 1 13.8, 55.6 ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,70298-88-3, its application will become more common.

Reference:
Patent; LYTIX BIOPHARMA AS; STENSEN, Wenche; SCHEVENELS, Florian; MARKO, Istvan, E.; SVENDSEN, John, Sigurd, Mj°en; WO2014/198848; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 70298-88-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 70298-88-3, name is 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, molecular formula is C10H14N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

nBuLi (2.5M in hexanes, 56.2 ml_, 140.5 mmol) was dropwise added to a solution of the title compound of Preparation 1a (10 g, 56.2 mmol) and N,N,N’,N’-tetramethylethylene- diamine (TMEDA) (20.9 ml_, 140.5 mmol) in diethyl ether (338 ml.) at -78 0C under argon and the resulting mixture was stirred at that temperature for 15 minutes and at -10 0C for 2 hours. Then, the reaction mixture was cooled down to -780C and 2-methoxybenzaldehyde (19.52 g, 140.5 mmol) in 34 ml_ of dry tetrahydrofuran was carefully added. After 15 minutes, the cooling bath was removed and the mixture stirred overnight at room temperature. Subsequently, water (100 mL) was added to the flask and it was extracted with ethyl acetate (3 x 200 mL), the organic solution was washed with brine, dried over sodium sulphate and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica flash, using hexane/ethyl acetate (4:1 ) as eluents, to yield the title compound (11.1 g, 63%) as a solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 70298-88-3, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2007/96072; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 70298-88-3, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, blongs to pyridine-derivatives compound. Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Step 2 To a solution of 2,2-dimethyl-N-pyridin-3-yl-propionamide (3.0 g, 17.0 mmol) in dry THF (50 mL) was added t-BuLi in pentanes (28.0 mL, 1.5 M in pentanes) dropwise at -78 C. After the addition, the reaction was stirred at -50 C. for 1 hr. Then benzaldehyde (2.17 g, 20.5 mmol) was added at -78 C. The mixture was allowed to warm to room temperature and stirred overnight. The mixture was quenched with chilly saturated NH4Cl (60 mL) and extracted with EA (60 mL*3). The organic layers were washed with brine (100 mL), dried over anhydrous Na2SO4 and concentrated to give crude product, which was purified by silica gel column (PE) to afford N-[4-(hydroxy-phenyl-methyl)-pyridin-3-yl]-2,2-dimethyl-propionamide (1.60 g, yield: 33%) as a yellow solid. 1H NMR (300 MHz , CDCl3): delta=9.34 (s, 1H), 8.73 (brs, 1H), 8.25 (d, J=4.8 Hz, 1H), 7.36-7.28 (m, 5H), 7.05 (d, J=5.2 Hz, 1H), 5.89 (s, 1H), 1.31 (s, 9H) .

The synthetic route of 70298-88-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanford-Burnham Medical Research Institute; The Royal Institution for the Advancement of Learning / McGill University; The Government of the United States of America as Represented by the Secretary of the Department of; RONAI, Ze’ev; PINKERTON, Anthony B.; FENG, Yongmei; TOPISIROVIC, Ivan; BROWN, Kevin; HASSIG, Christian A.; (155 pag.)US2018/44324; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem