Category: 70298-89-4

Application of 70298-89-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 70298-89-4, name is 2,2-Dimethyl-N-pyridin-4-yl-propionamide, molecular formula is C10H14N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

N-(Pyridin-4-yl)pivalamide (377 mg, 2.12 mmol) was dissolved in anhydrous tetrahydrofuran under inert atmosphere and cooled to – 78 °C. Within 1 h, a 1.6 M hexane solution of buthyl-lithium (3.3 mL, 5.29 mmol, 2.5eq) was added drop wise. Then the reaction mixture was warmed to 0 °C, stirred for 3 h, and anhydrous dimethylformamide (0.5 mL, 6.35 mmol, 3eq) in anhydrous tetrahydrofuran (3 mL) was added. Subsequently, the solution was warmed to room temperature and stirred for an additional 45 min. The mixture was poured onto a mixture of 6 N HCI (5 mL) and ice (5 g). After stirring for 5 min, the solution was neutralized with K2C03 (3.3 g) and extracted with diethylether. The organic layer was dried over MgS0 and the solvent was removed in vacuo. The residue was purified bycolumnchromatography to get N-(3-formylpyridin-4-yl)pivalamide (258 mg, 59 percent).

According to the analysis of related databases, 70298-89-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; WO2013/13817; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 70298-89-4, Adding some certain compound to certain chemical reactions, such as: 70298-89-4, name is 2,2-Dimethyl-N-pyridin-4-yl-propionamide,molecular formula is C10H14N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 70298-89-4.

General procedure: To a stirred solution of 1a (0.36 g, 2.0mmol) in THF (5 mL) at ?78 C was added n-BuLi (1.6 M in hexane; 4.0 mmol) dropwise. After 15 min,temperature was raised to 0 C and stirring was continued for 2.5 h. Then, the mixture was cooled to ?78C and MeCOCO2Me (0.20 g, 2.0 mmol) was added dropwise. The resulting mixture was graduallywarmed to 0 C, treated with saturated aqueous NH4Cl (20 mL), and extracted with AcOEt (3 × 15 mL).The combined extracts were washed with brine (15 mL), dried (Na2SO4), and concentrated by evaporation.The residue was purified by column chromatography on SiO2 (AcOEt/hexane 1:3) to afford 2a (0.28 g,50percent);

According to the analysis of related databases, 70298-89-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kobayashi, Kazuhiro; Kosuna, Risa; Chikazawa, Yuuki; Heterocycles; vol. 92; 9; (2016); p. 1643 – 1653;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem